Relationship between smoking and ALS: Mendelian randomisation interrogation of causality

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Smoking and amyotrophic lateral sclerosis: A mendelian randomization study

(2019) Yiqiang Zhan et al.   ANNALS OF NEUROLOGY

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

(2019) Sara Bandres‐Ciga et al.   ANNALS OF NEUROLOGY

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

(2019) Tom G Richardson et al.   eLife

Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR

(2019) Susan Peters et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Within family Mendelian randomization studies

(2019) Neil M Davies et al.   HUMAN MOLECULAR GENETICS

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study

(2019) Robyn E. Wootton et al.   PSYCHOLOGICAL MEDICINE

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

(2019) Louise A. C. Millard et al.   PLoS Genetics

Evaluating the potential role of pleiotropy in Mendelian randomization studies

(2018) Gibran Hemani et al.   HUMAN MOLECULAR GENETICS

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

(2018) Aude Nicolas et al.   NEURON

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Triangulation in aetiological epidemiology

(2017) Debbie A. Lawlor et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization

(2016) Hyunseung Kang et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

(2016) Wouter van Rheenen et al.   NATURE GENETICS

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Smoking, Alcohol Consumption, and the Risk of Amyotrophic Lateral Sclerosis: A Population-based Study

(2012) S. W. de Jong et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Smoking Is Not a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis in an Australian Population

(2012) Roger Pamphlett et al.   NEUROEPIDEMIOLOGY

Smoking and Risk of Amyotrophic Lateral Sclerosis

(2011) Hao Wang et al.   ARCHIVES OF NEUROLOGY

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study

(2010) Alvaro Alonso et al.   BMC Neurology

An estimate of amyotrophic lateral sclerosis heritability using twin data

(2010) A. Al-Chalabi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) A. Alonso et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE