Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects
Authors
Keywords
-
Journal
Journal for ImmunoTherapy of Cancer
Volume 9, Issue 7, Pages e002773
Publisher
BMJ
Online
2021-07-07
DOI
10.1136/jitc-2021-002773
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Metformin plus lrinotecan in patients with refractory colorectal cancer: a phase 2 clinical trial
- (2021) Arinilda Campos Bragagnoli et al. BRITISH JOURNAL OF CANCER
- CD8 infiltration is associated with disease control and tobacco exposure in intermediate-risk oropharyngeal cancer
- (2020) J. O. Kemnade et al. Scientific Reports
- Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer
- (2020) Jason R Brown et al. JCI Insight
- Tobacco exposure as a major modifier of oncologic outcomes in human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma
- (2020) Hesham Elhalawani et al. BMC CANCER
- Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy
- (2019) Aurelie Hanoteau et al. Journal for ImmunoTherapy of Cancer
- Emerging Trends in Metformin Prescribing in the United States from 2000 to 2015
- (2019) Samantha Le et al. CLINICAL DRUG INVESTIGATION
- Protocol-specified final analysis of the phase 3 KEYNOTE-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).
- (2019) Danny Rischin et al. JOURNAL OF CLINICAL ONCOLOGY
- Metformin inhibits progression of Head and Neck Squamous Cell Carcinoma by acting Directly on Carcinoma Initiating Cells
- (2019) Xingyu Wu et al. CANCER RESEARCH
- Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma
- (2019) Oscar Arrieta et al. JAMA Oncology
- Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition
- (2019) Jared M. Newton et al. Journal for ImmunoTherapy of Cancer
- Phase 1 dose‐finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer
- (2019) Shuchi Gulati et al. CANCER
- Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study
- (2019) Barbara Burtness et al. LANCET
- Metformin effects on FOXP3 + and CD8 + T cell infiltrates of head and neck squamous cell carcinoma
- (2019) Dev Amin et al. LARYNGOSCOPE
- Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin
- (2019) Saman Bahrambeigi et al. BIOCHEMICAL PHARMACOLOGY
- Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
- (2018) Lifeng Li et al. CANCER RESEARCH
- Mouse model of postsurgical primary tumor recurrence and regional lymph node metastasis progression in HPV-related head and neck cancer
- (2018) Maxime Mermod et al. INTERNATIONAL JOURNAL OF CANCER
- Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis
- (2018) Guohui Qin et al. OncoImmunology
- Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
- (2018) Jong-Ho Cha et al. MOLECULAR CELL
- Protective effects of metformin, statins and anti-inflammatory drugs on head and neck cancer: A systematic review
- (2018) Constanza Saka Herrán et al. ORAL ONCOLOGY
- TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy
- (2018) Padmini Jayaraman et al. OncoImmunology
- Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy
- (2018) Razvan Cristescu et al. SCIENCE
- IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
- (2017) Mark Ayers et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial
- (2017) Joseph Curry et al. LARYNGOSCOPE
- Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
- (2016) Robert L. Ferris et al. NEW ENGLAND JOURNAL OF MEDICINE
- Diabetes mellitus, metformin and head and neck cancer
- (2016) Rejane Augusta de Oliveira Figueiredo et al. ORAL ONCOLOGY
- Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia
- (2016) Nicole E. Scharping et al. Cancer Immunology Research
- The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
- (2015) Julianna Blagih et al. IMMUNITY
- Immune-mediated antitumor effect by type 2 diabetes drug, metformin
- (2015) Shingo Eikawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin may reduce oral cancer risk in patients with type 2 diabetes
- (2015) Chin-Hsiao Tseng Oncotarget
- Monocyte-Derived Dendritic Cells Are Essential for CD8+ T Cell Activation and Antitumor Responses After Local Immunotherapy
- (2015) Sabine Kuhn et al. Frontiers in Immunology
- Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer
- (2014) F. Parikh et al. CANCER RESEARCH
- Effect of metformin on the incidence of head and neck cancer in diabetics
- (2014) Yung-Chang Yen et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer
- (2014) SOICHIRO HONJO et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells
- (2014) A. Janzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- AMPKα1: A glucose sensor that controls CD8 T-cell memory
- (2013) Julia Rolf et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Association between metformin use and improved survival in patients with laryngeal squamous cell carcinoma
- (2013) Vlad C. Sandulache et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
- (2013) Madhusudhanan Sukumar et al. JOURNAL OF CLINICAL INVESTIGATION
- Metformin use and improved response to therapy in rectal cancer
- (2013) Heath D. Skinner et al. Cancer Medicine
- Metformin use and improved response to therapy in esophageal adenocarcinoma
- (2012) Heath D. Skinner et al. ACTA ONCOLOGICA
- Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions
- (2012) L. Vitale-Cross et al. Cancer Prevention Research
- Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis
- (2012) Hiroshi Noto et al. PLoS One
- Individualizing antimetabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status
- (2011) Vlad C. Sandulache et al. CANCER
- Metformin Decreases the Dose of Chemotherapy for Prolonging Tumor Remission in Mouse Xenografts Involving Multiple Cancer Cell Types
- (2011) D. Iliopoulos et al. CANCER RESEARCH
- TP53 Disruptive Mutations Lead to Head and Neck Cancer Treatment Failure through Inhibition of Radiation-Induced Senescence
- (2011) H. D. Skinner et al. CLINICAL CANCER RESEARCH
- Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
- (2011) G. Z. Rocha et al. CLINICAL CANCER RESEARCH
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development
- (2011) Gerritje J.W. van der Windt et al. IMMUNITY
- Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells
- (2010) I. Ben Sahra et al. CANCER RESEARCH
- Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer
- (2009) William C. Spanos et al. ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
- Metformin - the gold standard in type 2 diabetes: what does the evidence tell us?
- (2009) E. Bosi DIABETES OBESITY & METABOLISM
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started