The Role of Mitochondria in Mood Disorders: From Physiology to Pathophysiology and to Treatment

In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

(2020) Sean N. O’Byrne et al.   MOLECULES

Accelerated aging in bipolar disorder: A comprehensive review of molecular findings and their clinical implications

(2020) Gabriel R. Fries et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondria, Microglia, and the Immune System—How Are They Linked in Affective Disorders?

(2019) Carsten Culmsee et al.   Frontiers in Psychiatry

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

(2019) Giuseppe Caruso et al.   Cells

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

(2019) Oliver D. Robertson et al.   Early Intervention in Psychiatry

Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder

(2019) Piotr Czarny et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role?

(2019) Giuseppe Caruso et al.   CURRENT MEDICINAL CHEMISTRY

Identification of diagnostic markers for major depressive disorder by cross-validation of data from whole blood samples

(2019) Huimei Wang et al.   PeerJ

Mitochondrial signaling in inflammation-induced depressive behavior in female and male rats: The role of glucocorticoid receptor

(2019) Zeljka Brkic et al.   BRAIN RESEARCH BULLETIN

Muscular and mitochondrial effects of long-term fluoxetine treatment in mice, combined with physical endurance exercise on treadmill

(2019) Abdulkarim Tutakhail et al.   LIFE SCIENCES

Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

(2019) Zdeněk Fišar et al.   MITOCHONDRION

The Many Faces of Mitochondrial Dysfunction in Depression: From Pathology to Treatment

(2019) Giuseppe Caruso et al.   Frontiers in Pharmacology

Physical Activity as a Predictor of Clinical Trial Outcomes in Bipolar Depression: A Subanalysis of a Mitochondrial-Enhancing Nutraceutical Randomized Controlled Trial

(2019) Melanie M. Ashton et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Mitochondrial plasticity in cell fate regulation

(2019) Amir Bahat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Important Role of Mitochondria and the Effect of Mood Stabilizers on Mitochondrial Function

(2019) M. ĽUPTÁK et al.   PHYSIOLOGICAL RESEARCH

S-Adenosylmethionine (SAMe) monotherapy for depression: an 8-week double-blind, randomised, controlled trial

(2019) Jerome Sarris et al.   PSYCHOPHARMACOLOGY

Investigation of mitochondrial DNA copy number in patients with major depressive disorder

(2019) Jae Kyung Chung et al.   PSYCHIATRY RESEARCH

Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies

(2018) Yao-Chin Wang et al.   BEHAVIOURAL NEUROLOGY

Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New Mechanistic Insights From Human Neuronal Models

(2018) Rupali Srivastava et al.   BIOLOGICAL PSYCHIATRY

Mitochondria: A Connecting Link In The Major Depressive Disorder Jigsaw

(2018) Shilpa Sharma et al.   Current Neuropharmacology

Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia

(2018) Giselli Scaini et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Mitochondria in health and disease

(2018) Sanjiban Chakrabarty et al.   MITOCHONDRION

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Neuroketotherapeutics: A modern review of a century-old therapy

(2018) Scott J. Koppel et al.   NEUROCHEMISTRY INTERNATIONAL

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies

(2018) Asli Ercan Dogan et al.   NEUROPSYCHOPHARMACOLOGY

Genes Linking Mitochondrial Function, Cognitive Impairment and Depression are Associated with Endophenotypes Serving Precision Medicine

(2018) Peter Petschner et al.   NEUROSCIENCE

Lactate in bipolar disorder: A systematic review and meta-analysis

(2018) Heidi Kuang et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes

(2018) Samira S. Valvassori et al.   PSYCHIATRY RESEARCH

The antioxidant potential of the Mediterranean diet in patients at high cardiovascular risk: an in-depth review of the PREDIMED

(2018) Hayley E Billingsley et al.   Nutrition & Diabetes

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments

(2018) Elisa Brietzke et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondrial DNA copy number of peripheral blood in bipolar disorder: The present study and a meta-analysis

(2018) Naruhisa Yamaki et al.   PSYCHIATRY RESEARCH

TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation

(2018) Giselli Scaini et al.   NEUROPSYCHOPHARMACOLOGY

Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease

(2018) María Gómez-Serrano et al.   Oxidative Medicine and Cellular Longevity

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders

(2018) Giuseppe Caruso et al.   PROGRESS IN NEUROBIOLOGY

Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival

(2017) Josef Finsterer et al.   EPILEPSY RESEARCH

Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats

(2017) Zeljka Brkic et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Exercise and mental health

(2017) Kathleen Mikkelsen et al.   MATURITAS

Acute and chronic treatment with quetiapine induces antidepressant-like behavior and exerts antioxidant effects in the rat brain

(2017) Zuleide M. Ignácio et al.   METABOLIC BRAIN DISEASE

Lithium ameliorates lipopolysaccharide-induced neurotoxicity in the cortex and hippocampus of the adult rat brain

(2017) Muhammad Sohail Khan et al.   NEUROCHEMISTRY INTERNATIONAL

Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress

(2017) Carla Nasca et al.   NEURON

Mitochondrial energy metabolism of rat hippocampus after treatment with the antidepressants desipramine and fluoxetine

(2017) Roberto Federico Villa et al.   NEUROPHARMACOLOGY

Mechanisms of action and clinical efficacy of NMDA receptor modulators in mood disorders

(2017) Mehdi Ghasemi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A model of the mitochondrial basis of bipolar disorder

(2017) Gerwyn Morris et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Oxidative stress, inflammation and treatment response in major depression

(2017) Daniel Lindqvist et al.   PSYCHONEUROENDOCRINOLOGY

Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond

(2017) Tadafumi Kato   SCHIZOPHRENIA RESEARCH

DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca 2+ Transfer through the MAM

(2017) Sung Jin Park et al.   Cell Reports

Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

(2017) Jarmon G. Lees et al.   Stem Cells International

Perturbations in the apoptotic pathway and mitochondrial network dynamics in peripheral blood mononuclear cells from bipolar disorder patients

(2017) G Scaini et al.   Translational Psychiatry

Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using 31P-Magnetic Resonance Spectroscopy

(2017) Fei Du et al.   BIOLOGICAL PSYCHIATRY

The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment

(2016) Abdülhadi Cihangir Uguz et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial Dysfunction in Depression

(2016) Yashika Bansal et al.   Current Neuropharmacology

Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System

(2016) Vyara Todorova et al.   Current Neuropharmacology

Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders

(2016) Miroslav Adzic et al.   DRUG DEVELOPMENT RESEARCH

Impaired glucose metabolism moderates the course of illness in bipolar disorder

(2016) Rodrigo B. Mansur et al.   JOURNAL OF AFFECTIVE DISORDERS

Toxicity of lithium on isolated heart mitochondria and cardiomyocyte: A justification for its cardiotoxic adverse effect

(2016) Ahmad Salimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

N-Acetylcysteine in Depressive Symptoms and Functionality

(2016) Brisa S. Fernandes et al.   JOURNAL OF CLINICAL PSYCHIATRY

Effect of dietary fat and the circadian clock on the expression of brain-derived neurotrophic factor (BDNF)

(2016) Yoni Genzer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations

(2016) M Kataoka et al.   MOLECULAR PSYCHIATRY

Creatine affords protection against glutamate-induced nitrosative and oxidative stress

(2016) Mauricio P. Cunha et al.   NEUROCHEMISTRY INTERNATIONAL

Effect of desipramine and fluoxetine on energy metabolism of cerebral mitochondria

(2016) Roberto Federico Villa et al.   NEUROSCIENCE

Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications

(2016) Giselli Scaini et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacological targeting of redox regulation systems as new therapeutic approach for psychiatric disorders: A literature overview

(2016) Stefania Schiavone et al.   PHARMACOLOGICAL RESEARCH

The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft

(2016) Kathrina L. Marcelo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain

(2015) Zuleide Ignacio et al.   CURRENT NEUROVASCULAR RESEARCH

Diet and Bipolar Disorder: A Review of Its Relationship and Potential Therapeutic Mechanisms of Action

(2015) Adrian L. Lopresti et al.   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites

(2015) Rosalind Norkett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genetic variant in CAMKK2 gene is possibly associated with increased risk of bipolar disorder

(2015) Minoo Atakhorrami et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania

(2015) Samira S. Valvassori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Requirement of AMPK activation for neuronal metabolic-enhancing effects of antidepressant paroxetine

(2015) Jihyeon Jeong et al.   NEUROREPORT

CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity

(2015) Xiao Ou et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regulation of leukocyte tricarboxylic acid cycle in drug-naïve Bipolar Disorder

(2015) Rafael T. de Sousa et al.   NEUROSCIENCE LETTERS

Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain

(2015) Jéssica Lopes-Borges et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Mitochondrial function in the brain links anxiety with social subordination

(2015) Fiona Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Possible Benefit of Dietary Carnosine towards Depressive Disorders

(2015) Alan R. Hipkiss   Aging and Disease

Glutamate Metabolism in Major Depressive Disorder

(2014) Chadi G. Abdallah et al.   AMERICAN JOURNAL OF PSYCHIATRY

New functions of mitochondria associated membranes in cellular signaling

(2014) Alexander R. van Vliet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Peripheral blood lymphocytes from patients with bipolar disorder demonstrate apoptosis and differential regulation of advanced glycation end products and S100B

(2014) Paraskevi Moutsatsou et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications

(2014) George Anderson et al.   CURRENT PHARMACEUTICAL DESIGN

Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice

(2014) C. Chen et al.   Disease Models & Mechanisms

Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder

(2014) Rafael T de Sousa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondrial trafficking and anchoring in neurons: New insight and implications

(2014) Zu-Hang Sheng   JOURNAL OF CELL BIOLOGY

PlasmaL-Tryptophan Concentration in Major Depressive Disorder

(2014) Shintaro Ogawa et al.   JOURNAL OF CLINICAL PSYCHIATRY

The Efficacy of AdjunctiveN-Acetylcysteine in Major Depressive Disorder

(2014) Michael Berk et al.   JOURNAL OF CLINICAL PSYCHIATRY

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility

(2014) C Nasca et al.   MOLECULAR PSYCHIATRY

Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?

(2014) K. B. Busch et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes

(2014) Viola Tamási et al.   PLoS One

Mitochondrial DNA variation and increased oxidative damage in euthymic patients with bipolar disorder

(2014) Cheng-Chen Chang et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

An updated meta-analysis of oxidative stress markers in bipolar disorder

(2014) Nicole C. Brown et al.   PSYCHIATRY RESEARCH

Fluvoxamine alters the activity of energy metabolism enzymes in the brain

(2014) Gabriela K. Ferreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

New Developments in the Genetics of Bipolar Disorder

(2014) Gen Shinozaki et al.   Current Psychiatry Reports

Energetic and Dynamic: How Mitochondria Meet Neuronal Energy Demands

(2014) Dzhamilja Safiulina et al.   PLOS BIOLOGY

Neuroactive Peptides as Putative Mediators of Antiepileptic Ketogenic Diets

(2014) Carmela Giordano et al.   Frontiers in Neurology

A preliminary investigation on the efficacy of N-acetyl cysteine for mania or hypomania

(2013) Pedro Vieira da Silva Magalhães et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Terminal Axon Branching Is Regulated by the LKB1-NUAK1 Kinase Pathway via Presynaptic Mitochondrial Capture

(2013) Julien Courchet et al.   CELL

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

(2013) Grazyna Rajkowska et al.   CURRENT DRUG TARGETS

Novel routes to bipolar disorder drug discovery

(2013) Nicolas Hoertel et al.   Expert Opinion on Drug Discovery

Challenges in drug target discovery in bipolar disorder

(2013) Murtada Alsaif et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Caloric Restriction Followed by High Fat Feeding Predisposes to Oxidative Stress in Skeletal Muscle Mitochondria

(2013) R. Crescenzo et al.   HORMONE AND METABOLIC RESEARCH

The neurobiology of bipolar disorder: identifying targets for specific agents and synergies for combination treatment

(2013) Ana C. Andreazza et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Placebo-Controlled Trial of Acetyl-L-Carnitine and α-Lipoic Acid in the Treatment of Bipolar Depression

(2013) Brian P. Brennan et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects

(2013) Carolina Gubert et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Oxidative stress in early stage Bipolar Disorder and the association with response to lithium

(2013) Rafael T. de Sousa et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Gender-specific effects of fluoxetine on hippocampal glucocorticoid receptor phosphorylation and behavior in chronically stressed rats

(2013) Milos Mitic et al.   NEUROPHARMACOLOGY

Brain region- and sex-specific modulation of mitochondrial glucocorticoid receptor phosphorylation in fluoxetine treated stressed rats: Effects on energy metabolism

(2013) Miroslav Adzic et al.   PSYCHONEUROENDOCRINOLOGY

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development

(2012) Andrew A Nierenberg et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Glutathione mediated reductive activation and mitochondrial dysfunction play key roles in lithium induced oxidative stress and cytotoxicity in liver

(2012) Mohammad Reza Eskandari et al.   BIOMETALS

Effects of alpha-lipoic acid in an animal model of mania induced byd-amphetamine

(2012) Danielle S Macêdo et al.   BIPOLAR DISORDERS

Maintenance N-acetyl cysteine treatment for bipolar disorder: A double-blind randomized placebo controlled trial

(2012) Michael Berk et al.   BMC Medicine

Update on lipids and mitochondrial function

(2012) William C. Stanley et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The Role of Oxidative Stress in Depressive Disorders

(2012) Tanja Maria Michel et al.   CURRENT PHARMACEUTICAL DESIGN

Effects of fluoxetine on plasticity and apoptosis evoked by chronic stress in rat prefrontal cortex

(2012) Ana Djordjevic et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Coenzyme Q10 Effects on Creatine Kinase Activity and Mood in Geriatric Bipolar Depression

(2012) Brent P. Forester et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

(2012) Annamaria Cattaneo et al.   NEUROPSYCHOPHARMACOLOGY

Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine

(2012) Gustavo Feier et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effects of lithium therapy on Na+–K+-ATPase activity and lipid peroxidation in bipolar disorder

(2012) Ushasi Banerjee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Effects of N-acetyl cysteine on cognitive function in bipolar disorder

(2012) Olivia M. Dean et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondrial Mutations and Polymorphisms in Psychiatric Disorders

(2012) Adolfo Sequeira et al.   Frontiers in Genetics

Activity of mitochondrial respiratory chain is increased by chronic administration of antidepressants.

(2011) Giselli Scaini et al.   ACTA NEUROPSYCHIATRICA

The creatine kinase reaction: a simple reaction with functional complexity

(2011) Kent Sahlin et al.   AMINO ACIDS

Striatal dopamine transporter availability in unmedicated bipolar disorder

(2011) Amit Anand et al.   BIPOLAR DISORDERS

Adjunctive nutraceuticals with standard pharmacotherapies in bipolar disorder: a systematic review of clinical trials

(2011) Jerome Sarris et al.   BIPOLAR DISORDERS

Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder

(2011) Takuji Uemura et al.   BIPOLAR DISORDERS

Calcium signaling around Mitochondria Associated Membranes (MAMs)

(2011) Simone Patergnani et al.   Cell Communication and Signaling

Mitochondrial toxicity of antiepileptic drugs and their tolerability in mitochondrial disorders

(2011) Josef Finsterer et al.   Expert Opinion on Drug Metabolism & Toxicology

Therapeutic use of omega-3 fatty acids in bipolar disorder

(2011) Vicent Balanzá-Martínez et al.   Expert Review of Neurotherapeutics

The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial

(2011) Michael Berk et al.   JOURNAL OF AFFECTIVE DISORDERS

Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: A meta-analysis and meta-regression

(2011) Yang Liu et al.   JOURNAL OF AFFECTIVE DISORDERS

Placebo-Controlled Adjunctive Trial of Pramipexole in Patients With Bipolar Disorder

(2011) Katherine E. Burdick et al.   JOURNAL OF CLINICAL PSYCHIATRY

Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants

(2011) O Malkesman et al.   MOLECULAR PSYCHIATRY

Antidepressant Drugs Diversely Affect Autophagy Pathways in Astrocytes and Neurons—Dissociation from Cholesterol Homeostasis

(2011) Jürgen Zschocke et al.   NEUROPSYCHOPHARMACOLOGY

Macromolecular organization of ATP synthase and complex I in whole mitochondria

(2011) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluoxetine affects hippocampal plasticity, apoptosis and depressive-like behavior of chronically isolated rats

(2011) Ana Djordjevic et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Systemic illness moderates the impact of N-acetyl cysteine in bipolar disorder

(2011) P.V. Magalhães et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Connectivity between mitochondrial functions and psychiatric disorders

(2011) Jana Hroudová et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: The CRESCEND study

(2011) Su-Jin Yang et al.   PSYCHIATRY RESEARCH

N-acetylcysteine for major depressive episodes in bipolar disorder

(2011) Pedro V Magalhães et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

(2010) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

(2010) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

(2010) Ana C. Andreazza et al.   ARCHIVES OF GENERAL PSYCHIATRY

The role of mitochondrial dysfunction in psychiatric disease

(2010) Fernando Scaglia   Developmental Disabilities Research Reviews

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

(2010) Hayley B. Clay et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroup analysis of a randomized placebo-controlled trial

(2010) P.V. Magalhães et al.   JOURNAL OF AFFECTIVE DISORDERS

Effects of mood stabilizers on mitochondrial respiratory chain activity in brain of rats treated with d-amphetamine

(2010) Samira S. Valvassori et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Peripheral biomarkers and illness activity in bipolar disorder

(2010) Flávio Kapczinski et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet

(2010) Julie B. Milder et al.   NEUROBIOLOGY OF DISEASE

Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects

(2010) Jorge A. Quiroz et al.   NEUROPSYCHOBIOLOGY

Treatment with olanzapine, fluoxetine and olanzapine/fluoxetine alters citrate synthase activity in rat brain

(2010) Fabiano R. Agostinho et al.   NEUROSCIENCE LETTERS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Folic acid efficacy as an alternative drug added to sodium valproate in the treatment of acute phase of mania in bipolar disorder: a double-blind randomized controlled trial

(2009) A. H. Behzadi et al.   ACTA PSYCHIATRICA SCANDINAVICA

Structure and Organization of Mitochondrial Respiratory Complexes: A New Understanding of an Old Subject

(2009) Giorgio Lenaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of cloned BKCa channels in nitric oxide-induced apoptosis of HEK293 cells

(2009) Yu-Guang Ma et al.   APOPTOSIS

The Neurogenic Basic Helix-Loop-Helix Transcription Factor NeuroD6 Concomitantly Increases Mitochondrial mass and Regulates Cytoskeletal Organization in the Early Stages of Neuronal Differentiation

(2009) Kristin Kathleen Baxter et al.   ASN Neuro

New extension of the Mitchell Theory for oxidative phosphorylation in mitochondria of living organisms

(2009) Bernhard Kadenbach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

(2009) Andrew H. Miller et al.   BIOLOGICAL PSYCHIATRY

The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis

(2009) Rodrigo Machado-Vieira et al.   BIPOLAR DISORDERS

Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue

(2009) Iris C Maurer et al.   BIPOLAR DISORDERS

Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia

(2009) Jun-Feng Wang et al.   BIPOLAR DISORDERS

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation

(2009) D. M.  Kirby et al.   CELL PROLIFERATION

Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia

(2009) Regina Taurines et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage

(2009) Rosilla F. Bachmann et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Energy Use Associated with Neural Computation in the Cerebellum

(2009) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Antidepressant effect of Shudihuang on mice exposed to unpredictable chronic mild stress

(2009) Di Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

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(2009) Ahmet Korkmaz et al.   MOLECULAR MEDICINE

Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients

(2009) Hyung-Wook Kim et al.   NEUROBIOLOGY OF DISEASE

Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments

(2009) Jerome Sarris et al.   NUTRITION REVIEWS

Mitochondrial Dynamics in Mammalian Health and Disease

(2009) Marc Liesa et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Variants in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2009) Brandi Rollins et al.   PLoS One

Dynamic regulation of mitochondrial function by glucocorticoids

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total antioxidant capacity and total oxidant status in patients with major depression: Impact of antidepressant treatment

(2009) Birgul Elbozan Cumurcu et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Pretreatment regional brain glucose uptake in the midbrain on PET may predict remission from a major depressive episode after three months of treatment

(2009) Matthew S. Milak et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Mitochondrial involvement in psychiatric disorders

(2008) Ling Shao et al.   ANNALS OF MEDICINE

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

Functions and effects of creatine in the central nervous system

(2008) Robert H. Andres et al.   BRAIN RESEARCH BULLETIN

Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder

(2008) T KATO   CELL CALCIUM

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes

(2008) Cátia C.P. Aires et al.   FEBS LETTERS

Oxidative stress markers in bipolar disorder: A meta-analysis

(2008) Ana C. Andreazza et al.   JOURNAL OF AFFECTIVE DISORDERS

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

(2008) Gjumrakch Aliev et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The ketogenic diet increases mitochondrial glutathione levels

(2008) Stuart G. Jarrett et al.   JOURNAL OF NEUROCHEMISTRY

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

(2008) Paul L. Greer et al.   NEURON

Mitochondrially Mediated Plasticity in the Pathophysiology and Treatment of Bipolar Disorder

(2008) Jorge A Quiroz et al.   NEUROPSYCHOPHARMACOLOGY

Novel Drugs and Therapeutic Targets for Severe Mood Disorders

(2008) Sanjay J Mathew et al.   NEUROPSYCHOPHARMACOLOGY

Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases

(2008) N.Y. Calingasan et al.   NEUROSCIENCE

Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia

(2008) Satoshi Fuke et al.   NEUROSCIENCE LETTERS

Gene expression differences in bipolar disorder revealed by cDNA array analysis of post-mortem frontal cortex

(2003) Yarema B. Bezchlibnyk et al.   JOURNAL OF NEUROCHEMISTRY