In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

(2019) Ana Laura de Souza Almeida Matos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

(2019) Luigi Racioppi et al.   Nature Communications

CaM Kinase: Still Inspiring at 40

(2019) K. Ulrich Bayer et al.   NEURON

Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors

(2019) Gerson S. Profeta et al.   Scientific Reports

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model

(2018) Daniel J. Price et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CAMKs support development of acute myeloid leukemia

(2018) Xunlei Kang et al.   Journal of Hematology & Oncology

1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors

(2018) Christopher Asquith et al.   MOLECULES

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

(2018) Jin Gohda et al.   Scientific Reports

Calmodulin-binding proteins: A journey of 40 years

(2018) Rajendra K. Sharma et al.   CELL CALCIUM

Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors

(2018) André da Silva Santiago et al.   Scientific Reports

The Akt pathway in oncology therapy and beyond (Review)

(2018) George Nitulescu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells

(2017) Angela M. Gocher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the Role of CaMKIV in Homeostatic Plasticity

(2017) Julia Bleier et al.   JOURNAL OF NEUROSCIENCE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation

(2017) Matthew T. O’Brien et al.   Scientific Reports

Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD

(2017) Brian York et al.   Scientific Reports

The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models

(2016) Sen Zhang et al.   CLINICAL CANCER RESEARCH

CAMKK2, Regulated by Promoter Methylation, is a Prognostic Marker in Diffuse Gliomas

(2016) Da-Ming Liu et al.   CNS Neuroscience & Therapeutics

The Ca 2+ /Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft

(2016) Kathrina L. Marcelo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis

(2016) Matthew J. Billard et al.   PLoS One

Kinase hinge binding scaffolds and their hydrogen bond patterns

(2015) Li Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of CaMKK2 reverses age-associated decline in bone mass

(2015) Zachary J. Pritchard et al.   BONE

Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma

(2015) Yashwanth Subbannayya et al.   CANCER BIOLOGY & THERAPY

The camKK2/camKIV relay is an essential regulator of hepatic cancer

(2015) Fumin Lin et al.   HEPATOLOGY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

(2015) John W. Scott et al.   Scientific Reports

CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression

(2015) Linna Li et al.   Oncotarget

Androgen receptor: structure, role in prostate cancer and drug discovery

(2014) MH Eileen Tan et al.   ACTA PHARMACOLOGICA SINICA

MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer

(2014) Hao FU et al.   TUMOR BIOLOGY

Considerations regarding use of solvents in in vitro cell based assays

(2013) Michael Timm et al.   CYTOTECHNOLOGY

Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization

(2013) Anton Simeonov   Expert Opinion on Drug Discovery

Structural diversity of calmodulin binding to its target sites

(2013) Henning Tidow et al.   FEBS Journal

Inhibition of Ca2+/Calmodulin-Dependent Protein Kinase Kinase 2 Stimulates Osteoblast Formation and Inhibits Osteoclast Differentiation

(2013) Rachel L Cary et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Correction: A Fluorescence-Based Thermal Shift Assay Identifies Inhibitors of Mitogen Activated Protein Kinase Kinase 4

(2013) Sankar N. Krishna et al.   PLoS One

A Regulatory Feedback Loop Between Ca2+/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression

(2012) Loukia G. Karacosta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

(2012) Luigi Racioppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer

(2012) Takashi Shima et al.   PROSTATE

Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II

(2011) Kathryn A. Skelding et al.   CELL CYCLE

Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

(2011) Kohichiroh Yasui et al.   Clinical Gastroenterology and Hepatology

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

(2011) Charles E Massie et al.   EMBO JOURNAL

The Ca2+/Calmodulin-Dependent Protein Kinase Kinase, CaMKK2, Inhibits Preadipocyte Differentiation

(2011) Fumin Lin et al.   ENDOCRINOLOGY

Ca2+/Calmodulin-dependent Protein Kinase Kinase β Is Regulated by Multisite Phosphorylation

(2011) Michelle F. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ca2+/Calmodulin-dependent Protein Kinase Kinase in Complex with the Inhibitor STO-609

(2011) Mutsuko Kukimoto-Niino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells

(2010) Daniel E. Frigo et al.   CANCER RESEARCH

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1

(2010) Monika A. Davare et al.   JOURNAL OF NEURO-ONCOLOGY

Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: Our case series and literature review

(2010) Yoshitaka Takuma   WORLD JOURNAL OF GASTROENTEROLOGY

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Ca2+/Calmodulin-dependent Protein Kinase IV-mediated LIM Kinase Activation Is Critical for Calcium Signal-induced Neurite Outgrowth

(2009) Miyohiko Takemura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells

(2009) John M. Schmitt et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH

Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

(2008) Kristin A. Anderson et al.   Cell Metabolism

Activation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609)

(2008) P. Monteiro et al.   DRUG METABOLISM AND DISPOSITION

Knowledge Based Prediction of Ligand Binding Modes and Rational Inhibitor Design for Kinase Drug Discovery

(2008) Arup K. Ghose et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller

(2008) Luigi Racioppi et al.   TRENDS IN IMMUNOLOGY

Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

(2007) James S. Duncan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS