Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach

Role of poly (ADP-ribose) polymerase-1 in cadmium-induced cellular DNA damage and cell cycle arrest in rat renal tubular epithelial cell line NRK-52E

(2020) Tongwang Luo et al.   ENVIRONMENTAL POLLUTION

Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats

(2020) Tong Guan et al.   BIOMETALS

Effects of multiwalled carbon nanotubes co-exposure with cadmium on zebrafish cell line: Metal uptake and accumulation, oxidative stress, genotoxicity and cell cycle

(2020) Mariana Morozesk et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats

(2020) Tareq Aqeel et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats

(2020) Jian-Ri Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms

(2019) Kota Fujiki et al.   CELL DEATH AND DIFFERENTIATION

Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells

(2019) Xin Chou et al.   ARCHIVES OF TOXICOLOGY

Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis

(2019) Swarnalata Joardar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

(2019) Naoki Takahashi et al.   eLife

The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population

(2019) Chih-Yin Wu et al.   JOURNAL OF HAZARDOUS MATERIALS

Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-β1/Smad/Collagen IV Signalling

(2019) Sonjit Das et al.   MOLECULES

Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation

(2019) Jing Ge et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cadmium induces cytotoxicity through oxidative stress-mediated apoptosis pathway in duck renal tubular epithelial cells

(2019) Jionghan Zhuang et al.   TOXICOLOGY IN VITRO

Gap junctional intercellular communication and endoplasmic reticulum stress regulate chronic cadmium exposure induced apoptosis in HK-2 cells

(2018) Zehe Ge et al.   TOXICOLOGY LETTERS

The Comparative Toxicogenomics Database: update 2019

(2018) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Puerarin reverses cadmium-induced lysosomal dysfunction in primary rat proximal tubular cells via inhibiting Nrf2 pathway

(2018) Li-Yuan Wang et al.   BIOCHEMICAL PHARMACOLOGY

Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer

(2017) E. Jablonska et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Sinapic acid ameliorate cadmium-induced nephrotoxicity: In vivo possible involvement of oxidative stress, apoptosis, and inflammation via NF-κB downregulation

(2017) Mushtaq Ahmad Ansari et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Alleviation of cadmium-induced oxidative stress by trehalose via inhibiting the Nrf2-Keap1 signaling pathway in primary rat proximal tubular cells

(2017) Xin-Yu Wang et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Quantitative weight of evidence to assess confidence in potential modes of action

(2017) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Trehalose protects against cadmium-induced cytotoxicity in primary rat proximal tubular cells via inhibiting apoptosis and restoring autophagic flux

(2017) Xin-Yu Wang et al.   Cell Death & Disease

Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function

(2016) Xiang-Bin Song et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tubular and glomerular kidney effects in the Chinese general population with low environmental cadmium exposure

(2016) Dongyue Wang et al.   CHEMOSPHERE

Protective Effect of Cleistocalyx nervosum var. paniala Fruit Extract against Oxidative Renal Damage Caused by Cadmium

(2016) Warut Poontawee et al.   MOLECULES

Oxidative Signaling Response to Cadmium Exposure

(2016) Saïd Nemmiche   TOXICOLOGICAL SCIENCES

Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells

(2016) Keum-Young So et al.   TOXICOLOGY

Cadmium-induced oxidative damages in the human BJAB cells correlate with changes in intracellular trace elements levels and zinc transporters expression

(2016) Saïd Nemmiche et al.   TOXICOLOGY IN VITRO

Grape seed proanthocyanidins ameliorates cadmium-induced renal injury and oxidative stress in experimental rats through the up-regulation of nuclear related factor 2 and antioxidant responsive elements

(2015) Bashir Nazima et al.   Biochemistry and Cell Biology

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water

(2015) Ivy Moffat et al.   CRITICAL REVIEWS IN TOXICOLOGY

Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys

(2015) Vesna Matović et al.   FOOD AND CHEMICAL TOXICOLOGY

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

(2015) Richard A. Becker et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD)

(2015) A. Francina Webster et al.   PLoS One

Cadmium induced pathophysiology: Prophylactic role of edible jute (Corchorus olitorius) leaves with special emphasis on oxidative stress and mitochondrial involvement

(2013) Saikat Dewanjee et al.   FOOD AND CHEMICAL TOXICOLOGY

The protective effects of selenium on cadmium-induced oxidative stress and apoptosis via mitochondria pathway in mice kidney

(2013) Yang Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Cadmium Renal Toxicity via Apoptotic Pathways

(2012) Yasuyuki Fujiwara et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells

(2012) Hitomi Fujishiro et al.   Metallomics

The Reference Dose for Subchronic Exposure of Pigs to Cadmium Leading to Early Renal Damage by Benchmark Dose Method

(2012) Xiaosheng Wu et al.   TOXICOLOGICAL SCIENCES

The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database

(2011) A. P. Davis et al.   Database-The Journal of Biological Databases and Curation

Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs

(2010) Ivan Sabolić et al.   BIOMETALS

Heavy metal poisoning: the effects of cadmium on the kidney

(2010) Nikhil Johri et al.   BIOMETALS

Cadmium stress: an oxidative challenge

(2010) Ann Cuypers et al.   BIOMETALS

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

(2010) M.E. (Bette) Meek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Population Toxicokinetic Modeling of Cadmium for Health Risk Assessment

(2009) Billy Amzal et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cadmium, Environmental Exposure, and Health Outcomes

(2009) Soisungwan Satarug et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Role of Oxidative Stress, Apoptosis, and Intracellular Homeostasis in Primary Cultures of Rat Proximal Tubular Cells Exposed to Cadmium

(2008) Lin Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Cadmium-induced oxidative stress and DNA damage in kidney of pregnant female rats

(2008) Sihem Chater et al.   COMPTES RENDUS BIOLOGIES

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Cadmium generates reactive oxygen- and carbon-centered radical species in rats: Insights from in vivo spin-trapping studies

(2008) Jie Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Naringenin protects against cadmium-induced oxidative renal dysfunction in rats

(2008) J. Renugadevi et al.   TOXICOLOGY