Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets

Chemogenetic and optogenetic control of post-translational modifications through genetic code expansion

(2021) Wenyuan Zhou et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA

(2020) Min Zhang et al.   CELL RESEARCH

Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy

(2020) Lisa Mészáros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prediction of organic homolytic bond dissociation enthalpies at near chemical accuracy with sub-second computational cost

(2020) Peter C. St. John et al.   Nature Communications

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

(2020) Ekaterina V. Vinogradova et al.   CELL

Discovery of small-molecule enzyme activators by activity-based protein profiling

(2020) Bernard P. Kok et al.   Nature Chemical Biology

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474

(2019) Zhen Huang et al.   ACS Chemical Biology

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer

(2019) Abel H. Y. Tan et al.   Frontiers in Immunology

Chemoproteomics and Chemical Probes for Target Discovery

(2018) Gerard Drewes et al.   TRENDS IN BIOTECHNOLOGY

Global profiling of lysine reactivity and ligandability in the human proteome

(2017) Stephan M. Hacker et al.   Nature Chemistry

Clinical chemoproteomics—Opportunities and obstacles

(2017) Lyn H. Jones et al.   Science Translational Medicine

Proteome-wide covalent ligand discovery in native biological systems

(2016) Keriann M. Backus et al.   NATURE

Chemoproteomic profiling and discovery of protein electrophiles in human cells

(2016) Megan L. Matthews et al.   Nature Chemistry

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

(2015) Helai P. Mohammad et al.   CANCER CELL

N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes

(2015) Cynthia A. Morgan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug-induced regeneration in adult mice

(2015) Yong Zhang et al.   Science Translational Medicine

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

(2015) Joel D. W. Toh et al.   Chemical Science

A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1

(2014) Polina Prusevich et al.   ACS Chemical Biology

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

(2014) Gaofeng Xiong et al.   BMC CANCER

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

NRH:Quinone Oxidoreductase 2 (NQO2) Protein Competes with the 20 S Proteasome to Stabilize Transcription Factor CCAAT Enhancer-binding Protein α (C/EBPα), Leading to Protection against γ Radiation-induced Myeloproliferative Disease

(2013) Junkang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amine Oxidation Mediated by Lysine-Specific Demethylase 1: Quantum Mechanics/Molecular Mechanics Insights into Mechanism and Role of Lysine 661

(2013) Bora Karasulu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

(2013) Martin E Hess et al.   NATURE NEUROSCIENCE

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

Indolequinone Inhibitors of NRH:Quinone Oxidoreductase 2. Characterization of the Mechanism of Inhibition in both Cell-Free and Cellular Systems

(2011) Chao Yan et al.   BIOCHEMISTRY

Discovery of a Novel Class of Covalent Inhibitor for Aldehyde Dehydrogenases

(2011) May Khanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Comparative Analysis of Small Molecules and Histone Substrate Analogues as LSD1 Lysine Demethylase Inhibitors

(2010) Jeffrey C. Culhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases A and B†‡

(2008) Claudia Binda et al.   BIOCHEMISTRY

Probing protein structure by amino acid-specific covalent labeling and mass spectrometry

(2008) Vanessa Leah Mendoza et al.   MASS SPECTROMETRY REVIEWS