Article
Gastroenterology & Hepatology
Shivani U. Thanawala, David E. Kaplan, Gary W. Falk, Claire A. Beveridge, Douglas Schaubel, Marina Serper, Yu-Xiao Yang
Summary: Exposure to antibiotics is associated with an increased risk of esophageal adenocarcinoma, and the risk increases with the cumulative days of exposure.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Richard Shore, Jingru Yu, Weimin Ye, Jesper Lagergren, Martin Rutegard, Olof Akre, Par Stattin, Mats Lindblad
Summary: This study found that androgen deprivation therapy reduces the risk of non-cardia gastric adenocarcinoma, but does not decrease the risk of esophageal adenocarcinoma, cardia gastric adenocarcinoma, or esophageal squamous-cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Ramlah Khamis, Karthik B. Shanmugasundaram, Quan Zhou, Jennifer Lu, Zhen Zhang, Michelle M. Hill, Abu Ali Ibn Sina, Matt Trau, Alain Wuethrich
Summary: Endoscopy and tissue biopsy are the standard methods for diagnosing esophageal adenocarcinoma, but they are invasive and not suitable for population screening. In this study, a surface-enhanced Raman scattering lectin-immunoassay was developed to accurately measure serum levels of specific proteins. The results suggest that this method could be a promising liquid biopsy platform for screening esophageal adenocarcinoma.
ACS APPLIED NANO MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Prashanthi N. Thota, Motasem Alkhayyat, Juan D. Gomez Cifuentes, Mahnur Haider, James Bena, John McMichael, Davender P. Sohal, Siva Raja, Madhusudhan R. Sanaka
Summary: This study aimed to construct a nomogram for predicting the risk of locally advanced esophageal adenocarcinoma (EAC), which was validated internally. The study found that age, dysphagia, weight loss, protruding tumor, and tumor size were associated with locally advanced disease, while gastrointestinal bleeding and visible Barrett's esophagus were more likely to be associated with limited stage.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Oncology
R. S. A. Goedegebuure, M. Harrasser, L. K. de Klerk, T. S. van Schooten, N. C. T. van Grieken, M. Eken, M. S. Grifhorst, N. Pocorni, E. S. Jordanova, M. I. van Berge Henegouwen, R. E. Pouw, H. M. W. Verheul, J. J. van der Vliet, H. W. M. van Laarhoven, V. L. J. L. Thijssen, A. J. Bass, T. D. De Gruijl, S. Derks
Summary: In-depth analysis revealed a close relationship between the levels and distribution of T cells and the response to neoadjuvant CRT in esophageal adenocarcinoma patients. The presence of memory T cells in peripheral blood T cells contributes to a complete pathological response to CRT.
Article
Surgery
Erin M. Bayley, Megan L. Ivy, Jitesh B. Shewale, Phillip S. Ge, Mara B. Antonoff, Ashleigh M. Francis, Wayne L. Hofstetter, Reza J. Mehran, Ravi Rajaram, David C. Rice, Jack A. Roth, Boris Sepesi, Ara A. Vaporciyan, Garrett L. Walsh, J. Jack Lee, Brian E. Louie, Stephen G. Swisher
Summary: Clinical predictors of pathological complete response are unreliable for identifying patients suitable for organ-sparing treatment after neoadjuvant chemoradiation in esophageal cancer. This study aimed to identify high-risk predictors of residual carcinoma that may exclude patients from a selective surgical approach.
Article
Surgery
Siva Raja, Thomas W. Rice, Sudish C. Murthy, Usman Ahmad, Marie E. Semple, Eugene H. Blackstone, Hemant Ishwaran
Summary: This study demonstrates the importance of lymphadenectomy during esophagectomy for patients with adenocarcinoma of the esophagus and esophagogastric junction undergoing neoadjuvant therapy. Optimal range of nodes resected is associated with maximized survival, with a nonlinear relationship between lymph node resection and lifetime for different ypTNM cancer categories.
Article
Cardiac & Cardiovascular Systems
Smita Sihag, Sergio De La Torre, Meier Hsu, Tamar Nobel, Kay See Tan, Hans Gerdes, Pari Shah, Manjit Bains, David R. Jones, Daniela Molena
Summary: In patients with pathologic T1 esophageal adenocarcinoma, nodal involvement and tumor length are independent risk factors for recurrence, whereas tumors <2 cm in length without lymphovascular invasion are associated with a low risk of recurrence.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Roman O. Kowalchuk, Grant M. Spears, Lindsay K. Morris, Dawn Owen, Harry H. Yoon, Krishan Jethwa, Michael D. Chuong, Matthew J. Ferris, Michael G. Haddock, Christopher L. Hallemeier, Dennis Wigle, Steven H. Lin, Kenneth W. Merrell
Summary: This study aimed to investigate the impact of postoperative toxicity on patient quality of life and overall survival in esophageal cancer, and to determine whether patient and toxicity parameters could predict post-surgical cardiopulmonary total toxicity burden (CPTTB) and its association with short and long-term outcomes. The results showed that CPTTB was associated with decreased overall survival, longer post-esophagectomy length of stay, and higher death or readmission rate within 60 days of surgery.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Puja G. Khaitan, Tyler Holliday, Austin Carroll, Wayne L. Hofstetter, Erin M. Bayley, Nicolas Zhou, Sameer Desale, Thomas J. Watson
Summary: This study assessed the correlation between clinical complete response (ycCR) and pathologic complete response (ypCR) and found that current restaging tools cannot reliably predict ypCR after neoadjuvant chemoradiotherapy (nCRT). Although multimodal restaging appears to be a more accurate predictor of ypCR than any individual testing modality, ycCR cannot be relied upon to determine the need for esophagectomy.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Nanoscience & Nanotechnology
Zhao Jing, Kai Chen, Ling Gong
Summary: Esophageal cancer is a common malignancy in China with high mortality, and understanding the role of exosomes in cancer progression can help improve prognosis. Exosomes are small vesicular structures that contain various components involved in cell-to-cell communication and material exchange, playing a role in cancer growth, metastasis, and angiogenesis. They also have potential as diagnostic and prognostic markers in cancer. This review discusses the significance of exosomes in esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression, as well as their utility as diagnostic and prognostic biomarkers and therapeutic tools.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Oncology
Karl Knipper, Alexander I. Damanakis, Su Ir Lyu, Adrian Georg Simon, Isabell Wahler, Christiane J. Bruns, Wolfgang Schroeder, Thomas Schmidt, Alexander Quaas
Summary: Patients with esophageal cancer have a low overall survival rate despite multimodal therapy. This study found that NANOG-positive expression is significantly associated with worse overall survival and can be an independent risk factor for poor patient survival. This discovery suggests that NANOG could be used as a biomarker for intensified therapy and stricter follow-up, and NANOG-positive cancer cells could be a new therapeutic target if validated in further studies.
Article
Oncology
Julie A. Webster, Alain Wuethrich, Karthik B. Shanmugasundaram, Renee S. Richards, Wioleta M. Zelek, Alok K. Shah, Louisa G. Gordon, Bradley J. Kendall, Gunter Hartel, B. Paul Morgan, Matt Trau, Michelle M. Hill
Summary: This study developed the technology of the microfluidic EndoScreen chip and validated the blood biomarker JAC-C9 for early detection of esophageal adenocarcinoma (EAC). The use of blood biomarkers JAC-C9 and total C9 in addition to clinical risk factors improved EAC prediction in a test cohort, suggesting the potential for a simple blood test to help prioritize patients for endoscopic evaluation. Future work will expand the panel of markers on the EndoScreen chip to enable population screening and early diagnosis of EAC.
Review
Oncology
Caitlin T. Demarest, Andrew C. Chang
Summary: Esophagectomy is the main treatment for resectable esophageal cancer, with chemotherapy and chemoradiation as essential adjunct therapies. The optimal perioperative therapy remains controversial. Three landmark trials have established chemotherapy and chemoradiotherapy as standard care, with ongoing research aiming to clarify the roles of different regimens in esophageal cancer treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Cathy Bennett, Paul Moayyedi, Douglas A. Corley, John DeCaestecker, Yngve Falck-Ytter, Gary Falk, Nimish Vakil, Scott Sanders, Michael Vieth, John Inadomi, David Aldulaimi, Khek-Yu Ho, Robert Odze, Stephen J. Meltzer, Eamonn Quigley, Stuart Gittens, Peter Watson, Giovanni Zaninotto, Prasad G. Iyer, Leo Alexandre, Yeng Ang, James Callaghan, Rebecca Harrison, Rajvinder Singh, Pradeep Bhandari, Raf Bisschops, Bita Geramizadeh, Philip Kaye, Sheila Krishnadath, M. Brian Fennerty, Hendrik Manner, Katie S. Nason, Oliver Pech, Vani Konda, Krish Ragunath, Imdadur Rahman, Yvonne Romero, Richard Sampliner, Peter D. Siersema, Jan Tack, Tony C. K. Tham, Nigel Trudgill, David S. Weinberg, Jean Wang, Kenneth Wang, Jennie Y. Y. Wong, Stephen Attwood, Peter Malfertheiner, David MacDonald, Hugh Barr, Mark K. Ferguson, Janusz Jankowski
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Patrick Yachimski, Sabba Maqbool, Yasser M. Bhat, Joel E. Richter, Gary W. Falk, Michael F. Vaezi
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Gastroenterology & Hepatology
Katarina B. Greer, Gary W. Falk, Beth Bednarchik, Li Li, Amitabh Chak
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Article
Gastroenterology & Hepatology
Preetika Sinh, Rajeswari Anaparthy, Patrick E. Young, Srinivas Gaddam, Prashanthi Thota, Gokulakrishnan Balasubramanian, Mandeep Singh, April D. Higbee, Sachin Wani, Neil Gupta, Amit Rastogi, Sharad C. Mathur, Ajay Bansal, John D. Horwhat, Brooks D. Cash, Garyw. Falk, David A. Lieberman, John J. Vargo, Richard E. Sampliner, Prateek Sharma
Article
Oncology
Amanda B. Muir, Kara Dods, Yuli Noah, Sarit Toltzis, Prasanna Modayur Chandramouleeswaran, Anna Lee, Alain Benitez, Adam Bedenbaugh, Gary W. Falk, Rebecca G. Wells, Hiroshi Nakagawa, Mei-Lun Wang
EXPERIMENTAL CELL RESEARCH
(2015)
Editorial Material
Gastroenterology & Hepatology
Lauren Nephew, Susan Hilton, Gary W. Falk
Article
Gastroenterology & Hepatology
Aaron J. Small, James L. Araujo, Cadman L. Leggett, Aaron H. Mendelson, Anant Agarwalla, Julian A. Abrams, Charles J. Lightdale, Timothy C. Wang, Prasad G. Iyer, Kenneth K. Wang, Anil K. Rustgi, Gregory G. Ginsberg, Kimberly A. Forde, Phyllis A. Gimotty, James D. Lewis, Gary W. Falk, Meenakshi Bewtra
Editorial Material
Gastroenterology & Hepatology
Gary W. Falk
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2015)
Article
Gastroenterology & Hepatology
Matthew J. Whitson, Gary W. Falk
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2015)
Editorial Material
Gastroenterology & Hepatology
Gary W. Falk
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2015)
Editorial Material
Gastroenterology & Hepatology
Gary W. Falk
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2015)
Article
Gastroenterology & Hepatology
Vinay Chandrasekhara, David Desilets, Gary W. Falk, Haruhiro Inoue, John R. Romanelli, Thomas J. Savides, Stavros N. Stavropoulos, Lee L. Swanstrom
GASTROINTESTINAL ENDOSCOPY
(2015)
Article
Gastroenterology & Hepatology
Aaron J. Small, Scott E. Sutherland, Jessica S. Hightower, Carlos Guarner-Argente, Emma E. Furth, Michael L. Kochman, Kimberly A. Forde, Meenakshi Bewtra, Gary W. Falk, Gregory G. Ginsberg
GASTROINTESTINAL ENDOSCOPY
(2015)
Article
Gastroenterology & Hepatology
Fouad J. Moawad, Patrick E. Young, Srinivas Gaddam, Prashanth Vennalaganti, Prashanthi N. Thota, John Vargo, Brooks D. Cash, Gary W. Falk, Richard E. Sampliner, David Lieberman, Prateek Sharma
Article
Biochemistry & Molecular Biology
Jianping Kong, Kelly A. Whelan, Dorottya Laczko, Brendan Dang, Angeliz Caro Monroig, Ali Soroush, John Falcone, Ravi K. Amaravadi, Anil K. Rustgi, Gregory G. Ginsberg, Gary W. Falk, Hiroshi Nakagawa, John P. Lynch
MOLECULAR CARCINOGENESIS
(2016)
