Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides

Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial

(2020) Eline Birkeland et al.   EUROPEAN JOURNAL OF NUTRITION

The Network of Colonic Host Defense Peptides as an Innate Immune Defense Against Enteropathogenic Bacteria

(2020) Graham A. D. Blyth et al.   Frontiers in Immunology

Human Paneth cell α-defensin 5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice

(2019) Ida Søgaard Larsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Small In Vitro Fermentation Model for Screening the Gut Microbiota Effects of Different Fiber Preparations

(2019) Tsitko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deletion of the Casp8 gene in mice results in ileocolitis, gut barrier dysfunction, and malassimilation, which can be partially attenuated by inulin or sodium butyrate

(2019) Valentina Kaden-Volynets et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Butyric Acid and Leucine Induce α-Defensin Secretion from Small Intestinal Paneth Cells

(2019) Akiko Takakuwa et al.   Nutrients

Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration

(2018) Bjoern O. Schroeder et al.   Cell Host & Microbe

The prebiotic inulin improves substrate metabolism and promotes short-chain fatty acid production in overweight to obese men

(2018) Christina M. van der Beek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3

(2018) Ye Zhao et al.   Mucosal Immunology

In Vitro Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota

(2018) Sophie Fehlbaum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model

(2018) Silvia Moreno-Fernández et al.   Nutrients

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

(2017) VA Matheus et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Assessment of in Vitro Digestibility of Dietary Carbohydrates Using Rat Small Intestinal Extract

(2017) Alvaro Ferreira-Lazarte et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Intestinal Barrier Function and the Gut Microbiome Are Differentially Affected in Mice Fed a Western-Style Diet or Drinking Water Supplemented with Fructose

(2017) Valentina Volynets et al.   JOURNAL OF NUTRITION

Liquid fructose in Western-diet-fed mice impairs liver insulin signaling and causes cholesterol and triglyceride loading without changing calorie intake and body weight

(2017) Miguel Baena et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Specific inulin-type fructan fibers protect against autoimmune diabetes by modulating gut immunity, barrier function, and microbiota homeostasis

(2017) Kang Chen et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

(2017) Judith Raschig et al.   PLoS Pathogens

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway

(2017) Hui Yan et al.   PLoS One

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

(2017) Warren N. D’Souza et al.   PLoS One

Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats

(2016) Senthil A. Kumar et al.   BRITISH JOURNAL OF NUTRITION

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Nondigestible Fructans Alter Gastrointestinal Barrier Function, Gene Expression, Histomorphology, and the Microbiota Profiles of Diet-Induced Obese C57BL/6J Mice

(2016) Tzu-Wen Liu et al.   JOURNAL OF NUTRITION

Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10−/− colitis

(2016) Yvonne Hagenlocher et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Assessment of the Intestinal Barrier with Five Different Permeability Tests in Healthy C57BL/6J and BALB/cJ Mice

(2015) Valentina Volynets et al.   DIGESTIVE DISEASES AND SCIENCES

Carbohydrate catabolic diversity of bifidobacteria and lactobacilli of human origin

(2015) Heather P. McLaughlin et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Western-style diet induces insulin insensitivity and hyperactivity in adolescent male rats

(2015) Shannon E. Marwitz et al.   PHYSIOLOGY & BEHAVIOR

Paneth Cells: Maestros of the Small Intestinal Crypts

(2013) Hans C. Clevers et al.   Annual Review of Physiology

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase

(2013) Takuji Ishimoto et al.   HEPATOLOGY

Summer Meeting 2013: growth and physiology of bifidobacteria

(2013) L. De Vuyst et al.   JOURNAL OF APPLIED MICROBIOLOGY

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(2013) Astrid Spruss et al.   MOLECULAR MEDICINE

Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms

(2012) Shen-meng Gao et al.   EXPERIMENTAL HEMATOLOGY

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Lipopolysaccharide-Induced Bacterial Translocation Is Intestine Site-Specific and Associates with Intestinal Mucosal Inflammation

(2012) Chao Yue et al.   INFLAMMATION

Bacterial Stimulation of the TLR-MyD88 Pathway Modulates the Homeostatic Expression of Ileal Paneth Cell α-Defensins

(2012) A. Menendez et al.   Journal of Innate Immunity

CRS-peptides: unique defense peptides of mouse Paneth cells

(2012) M L Andersson et al.   Mucosal Immunology

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

(2011) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense

(2011) Zora Teltschik et al.   HEPATOLOGY

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals

(2011) Caroline M Hodin et al.   JOURNAL OF PATHOLOGY

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

(2011) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Level of Activation of the Unfolded Protein Response Correlates With Paneth Cell Apoptosis in Human Small Intestine Exposed to Ischemia/Reperfusion

(2010) Joep Grootjans et al.   GASTROENTEROLOGY

Wheat Dextrin, Psyllium, and Inulin Produce Distinct Fermentation Patterns, Gas Volumes, and Short-Chain Fatty Acid Profiles In Vitro

(2010) Derek A. Timm et al.   JOURNAL OF MEDICINAL FOOD

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

α-Defensins in Enteric Innate Immunity

(2009) Jennifer R. Mastroianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urine-based Detection of Intestinal Tight Junction Loss

(2009) Geertje Thuijls et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

In Vitro Kinetic Analysis of Fermentation of Prebiotic Inulin-Type Fructans by Bifidobacterium Species Reveals Four Different Phenotypes

(2008) G. Falony et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxin

(2008) Ina Bergheim et al.   JOURNAL OF HEPATOLOGY

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA