Shared Genetic Liability Between Major Depressive Disorder and Atopic Diseases

Discovery of potential asthma targets based on the clinical efficacy of Traditional Chinese Medicine formulas

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Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

(2019) David M. Howard et al.   NATURE NEUROSCIENCE

Probabilistic fine-mapping of transcriptome-wide association studies

(2019) Nicholas Mancuso et al.   NATURE GENETICS

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Estrogen and estrogen receptor signaling promotes allergic immune responses: Effects on immune cells, cytokines, and inflammatory factors involved in allergy

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Genome-wide association analysis of 350 000 Caucasians from the UK Biobank identifies novel loci for asthma, hay fever and eczema.

(2019) Åsa Johansson et al.   HUMAN MOLECULAR GENETICS

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation

(2019) Oleksandr Frei et al.   Nature Communications

The Roles of Sex Hormones in the Course of Atopic Dermatitis

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Atopic Eczema in Adulthood and Risk of Depression and Anxiety: A Population-Based Cohort Study

(2019) Yochai Schonmann et al.   Journal of Allergy and Clinical Immunology-In Practice

The equine asthma model of airway remodeling: from a veterinary to a human perspective

(2019) Michela Bullone et al.   CELL AND TISSUE RESEARCH

Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis

(2019) Zhaozhong Zhu et al.   EUROPEAN RESPIRATORY JOURNAL

Mental health impairment among children with atopic dermatitis: a U.S. population-based cross-sectional study of the 2013-2017 National Health Interview Survey

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Neonatal treatment with clomipramine modifies the expression of estrogen receptors in brain areas of male adult rats

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Epidemiology of atopic dermatitis in adults: Results from an international survey

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Hormones, sex, and asthma

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A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases

(2018) Zhaozhong Zhu et al.   NATURE GENETICS

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

(2018) Naomi R. Wray et al.   NATURE GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

(2018) Mats Nagel et al.   NATURE GENETICS

Analysis of shared heritability in common disorders of the brain

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Causal associations between risk factors and common diseases inferred from GWAS summary data

(2018) Zhihong Zhu et al.   Nature Communications

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

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The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

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Association Between Asthma and Depression: A National Cohort Study

(2018) Hyo Geun Choi et al.   Journal of Allergy and Clinical Immunology-In Practice

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

EigenGWAS: finding loci under selection through genome-wide association studies of eigenvectors in structured populations

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

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Risk of developing major depressive disorder and anxiety disorders among adolescents and adults with atopic dermatitis: A nationwide longitudinal study

(2015) Chih-Ming Cheng et al.   JOURNAL OF AFFECTIVE DISORDERS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

The Relationship between Depression and Asthma: A Meta-Analysis of Prospective Studies

(2015) Yong-hua Gao et al.   PLoS One

MAGMA: Generalized Gene-Set Analysis of GWAS Data

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Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective Study

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Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

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Tryptophan: The key to boosting brain serotonin synthesis in depressive illness

(2013) Abdulla A-B Badawy   JOURNAL OF PSYCHOPHARMACOLOGY

Pleiotropy in complex traits: challenges and strategies

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Burden of Depressive Disorders by Country, Sex, Age, and Year: Findings from the Global Burden of Disease Study 2010

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A Subset-Based Approach Improves Power and Interpretation for the Combined Analysis of Genetic Association Studies of Heterogeneous Traits

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Trends in common rhinologic illnesses: Analysis of U.S. healthcare surveys 1995-2007

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Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

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