How Do Uterine Natural Killer and Innate Lymphoid Cells Contribute to Successful Pregnancy?

Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss

(2021) Chuang Guo et al.   Cell Discovery

Continuous human uterine NK cell differentiation in response to endometrial regeneration and pregnancy

(2021) Benedikt Strunz et al.   Science Immunology

The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

(2021) Norman Shreeve et al.   IMMUNITY

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

(2020) Oisín Huhn et al.   Nature Communications

Innate lymphoid cells are required for endometrial resistance to Chlamydia trachomatis infection

(2020) Hong Xu et al.   INFECTION AND IMMUNITY

Human Term Pregnancy Decidual NK Cells Generate Distinct Cytotoxic Responses

(2020) Ricardo de Mendonça Vieira et al.   JOURNAL OF IMMUNOLOGY

Helper-like Innate Lymphoid Cells in Humans and Mice

(2020) Sophie Guia et al.   TRENDS IN IMMUNOLOGY

Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

(2020) Ângela C. Crespo et al.   CELL

Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry

(2020) Anita van der Zwan et al.   Frontiers in Immunology

Selective expansion and CMV-dependency in pregnancy trained human endometrial NK cells

(2019) D. Feyaerts et al.   Cellular & Molecular Immunology

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury

(2019) Bobbi Fleiss et al.   Frontiers in Endocrinology

Human liver-derived CXCR6+ NK cells are predominantly educated through NKG2A and show reduced cytokine production

(2019) Sebastian Lunemann et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Correction: High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia

(2019) Oisín Huhn et al.   JOURNAL OF IMMUNOLOGY

Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity

(2019) Naomi A. Yudanin et al.   IMMUNITY

Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow

(2019) Jennifer A. Walker et al.   IMMUNITY

Uterine Natural Killer Cells

(2019) Dorothy K. Sojka et al.   Frontiers in Immunology

Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection

(2019) Nabila Jabrane-Ferrat   Frontiers in Immunology

Peripheral lymph nodes contain migratory and resident innate lymphoid cell populations

(2019) Emma E. Dutton et al.   Science Immunology

Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling

(2019) John B. Pawlak et al.   JOURNAL OF CLINICAL INVESTIGATION

The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface

(2019) Henrieta Papúchová et al.   Frontiers in Immunology

Innate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor

(2018) Yi Xu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Interleukin 22 prevents lipopolysaccharide- induced preterm labor in mice†

(2018) Svetlana Dambaeva et al.   BIOLOGY OF REPRODUCTION

Trained Memory of Human Uterine NK Cells Enhances Their Function in Subsequent Pregnancies

(2018) Moriya Gamliel et al.   IMMUNITY

Diversification of human NK cells: Lessons from deep profiling

(2018) Aaron J. Wilk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

(2018) Adeline Crinier et al.   IMMUNITY

Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice

(2018) Dorothy K. Sojka et al.   JOURNAL OF IMMUNOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Fetal human leukocyte antigen-C and maternal killer-cell immunoglobulin-like receptors in cases of severe preeclampsia

(2018) Tine Graakjær Larsen et al.   PLACENTA

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

(2018) Iva Filipovic et al.   Nature Communications

Innate Lymphoid Cells in the Maternal and Fetal Compartments

(2018) Derek Miller et al.   Frontiers in Immunology

A single-cell survey of the human first-trimester placenta and decidua

(2018) Hemant Suryawanshi et al.   Science Advances

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

(2017) Yannick Simoni et al.   IMMUNITY

Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors

(2017) Binqing Fu et al.   IMMUNITY

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

A microfluidics assay to study invasion of human placental trophoblast cells

(2017) Yassen Abbas et al.   Journal of the Royal Society Interface

Liver-Resident NK Cells: The Human Factor

(2017) Victoria Male   TRENDS IN IMMUNOLOGY

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium

(2017) Paul J Brighton et al.   eLife

Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

(2017) Louise M. Gaynor et al.   Frontiers in Immunology

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets

(2016) Steven D. Scoville et al.   IMMUNITY

Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy

(2016) Philippa R. Kennedy et al.   JOURNAL OF IMMUNOLOGY

Composition and dynamics of the uterine NK cell KIR repertoire in menstrual blood

(2016) M A Ivarsson et al.   Mucosal Immunology

Mass cytometry: blessed with the curse of dimensionality

(2016) Evan W Newell et al.   NATURE IMMUNOLOGY

Evidence of innate lymphoid cell redundancy in humans

(2016) Frédéric Vély et al.   NATURE IMMUNOLOGY

Expression of KIR2DS1 by decidual natural killer cells increases their ability to control placental HCMV infection

(2016) Ângela C. Crespo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK cells control HIV‐1 infection of macrophages through soluble factors and cellular contacts in the human decidua

(2016) H. Quillay et al.   Retrovirology

The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy

(2016) Selma Boulenouar et al.   Frontiers in Immunology

Unique Eomes+ NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy

(2016) Elisa Montaldo et al.   Frontiers in Immunology

Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues

(2015) Virginie M. Renoux et al.   IMMUNITY

Composition, Development, and Function of Uterine Innate Lymphoid Cells

(2015) Jean-Marc Doisne et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+NK Cells

(2015) Nicole Marquardt et al.   JOURNAL OF IMMUNOLOGY

Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling

(2015) Rupsha Fraser et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Livebirth after uterus transplantation

(2015) Mats Brännström et al.   LANCET

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

AKIR Bcentromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia

(2015) Annettee Nakimuli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site

(2015) Chie-Pein Chen et al.   Reproductive Sciences

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

(2015) G. Gasteiger et al.   SCIENCE

Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes

(2015) Johan Siewiera et al.   Nature Communications

The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis

(2014) Naoko Kozuki et al.   BMC PUBLIC HEALTH

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Uterine NK cells: active regulators at the maternal-fetal interface

(2014) Ashley Moffett et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy

(2014) H. El Costa et al.   JOURNAL OF IMMUNOLOGY

Killer Ig-Like Receptor Expression in Uterine NK Cells Is Biased toward Recognition of HLA-C and Alters with Gestational Age

(2014) A. M. Sharkey et al.   JOURNAL OF IMMUNOLOGY

Endometrial NK Cells Are Special Immature Cells That Await Pregnancy

(2014) I. Manaster et al.   JOURNAL OF IMMUNOLOGY

Maternal KIR in Combination with Paternal HLA-C2 Regulate Human Birth Weight

(2014) S. E. Hiby et al.   JOURNAL OF IMMUNOLOGY

Identification of diverse innate lymphoid cells in human decidua

(2014) P Vacca et al.   Mucosal Immunology

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling

(2014) Jens Kieckbusch et al.   Nature Communications

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

CD8+ Effector T Cells at the Fetal-Maternal Interface, Balancing Fetal Tolerance and Antiviral Immunity

(2013) Tamara Tilburgs et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Immunology of the Maternal-Fetal Interface

(2013) Adrian Erlebacher   Annual Review of Immunology

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

(2013) V. Beziat et al.   BLOOD

In vivo generation of decidual natural killer cells from resident hematopoietic progenitors

(2013) L. Chiossone et al.   HAEMATOLOGICA

Natural killer cells in female infertility and recurrent miscarriage: a systematic review and meta-analysis

(2013) Srividya Seshadri et al.   HUMAN REPRODUCTION UPDATE

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Maternal uterine NK cell–activating receptor KIR2DS1 enhances placentation

(2013) Shiqiu Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Uterine NK Cells Regulate Endometrial Bleeding in Women and Are Suppressed by the Progesterone Receptor Modulator Asoprisnil

(2013) J. Wilkens et al.   JOURNAL OF IMMUNOLOGY

Uterine natural killer cells pace early development of mouse decidua basalis

(2013) A. P. Hofmann et al.   MOLECULAR HUMAN REPRODUCTION

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice

(2013) A.M. Felker et al.   PLACENTA

Genetic and Environmental Determinants of Human NK Cell Diversity Revealed by Mass Cytometry

(2013) A. Horowitz et al.   Science Translational Medicine

Human Cytomegalovirus Infection Elicits New Decidual Natural Killer Cell Effector Functions

(2013) Johan Siewiera et al.   PLoS Pathogens

Uterine natural killer cells initiate spiral artery remodeling in human pregnancy

(2012) Andrew Robson et al.   FASEB JOURNAL

Dynamic Shift from CD85j/ILT-2 to NKG2D NK Receptor Expression Pattern on Human Decidual NK during the First Trimester of Pregnancy

(2012) Romain Marlin et al.   PLoS One

The effect of pregnancy on the uterine NK cell KIR repertoire

(2011) Victoria Male et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review

(2011) A. W. Tang et al.   HUMAN REPRODUCTION

Ex vivo functional responses to HLA-G differ between blood and decidual NK cells

(2011) R. Apps et al.   MOLECULAR HUMAN REPRODUCTION

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

(2011) D. Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells

(2011) P. Vacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

(2010) Ivo Brosens et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Vascular-Leukocyte Interactions

(2010) Aleah D. Hazan et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age

(2010) G. E. Lash et al.   HUMAN REPRODUCTION

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Immature NK Cells, Capable of Producing IL-22, Are Present in Human Uterine Mucosa

(2010) V. Male et al.   JOURNAL OF IMMUNOLOGY

Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

(2010) Silke Paust et al.   NATURE IMMUNOLOGY

Human Decidual NK Cells from Gravid Uteri and NK Cells from Cycling Endometrium are Distinct NK Cell Subsets

(2010) H.D. Kopcow et al.   PLACENTA

Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression

(2010) P. Vacca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Decidual leucocyte populations in early to late gestation normal human pregnancy

(2009) P.J. Williams et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells

(2009) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study

(2009) S. Hernandez-Diaz et al.   BMJ-British Medical Journal

Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage

(2008) S.E. Hiby et al.   HUMAN REPRODUCTION

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies

(2008) Richard Apps et al.   IMMUNOLOGY

Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells

(2008) P. Vacca et al.   INTERNATIONAL IMMUNOLOGY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE