The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice

High Metabolic Function and Resilience of NKG2A-Educated NK Cells

(2020) Andrew J. Highton et al.   Frontiers in Immunology

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

(2020) Valgerdur Steinthorsdottir et al.   Nature Communications

The HLA-B -21 dimorphism impacts on NK cell education and clinical outcome of immunotherapy in acute myeloid leukemia

(2019) Alexander Hallner et al.   BLOOD

The Placental Transcriptome in Late Gestational Hypoxia Resulting in Murine Intrauterine Growth Restriction Parallels Increased Risk of Adult Cardiometabolic Disease

(2019) Alison Chu et al.   Scientific Reports

Remodeling of secretory lysosomes during education tunes functional potential in NK cells

(2019) Jodie P. Goodridge et al.   Nature Communications

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Pre-eclampsia: pathophysiology and clinical implications

(2019) Graham J Burton et al.   BMJ-British Medical Journal

Novel Approach to Cell Surface Discrimination Between KIR2DL1 Subtypes and KIR2DS1 Identifies Hierarchies in NK Repertoire, Education, and Tolerance

(2019) Jean-Benoît Le Luduec et al.   Frontiers in Immunology

The immunological code of pregnancy

(2019) Francesco Colucci   SCIENCE

Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

(2019) Xiaoqian Zhang et al.   Nature Communications

Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

(2019) Effie W Petersdorf et al.   Lancet Haematology

Pathophysiology of placental-derived fetal growth restriction

(2018) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Natural killer cell education in human health and disease

(2018) Jeanette E Boudreau et al.   CURRENT OPINION IN IMMUNOLOGY

ElevatedHLA-Aexpression impairs HIV control through inhibition of NKG2A-expressing cells

(2018) Veron Ramsuran et al.   SCIENCE

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

(2018) Iva Filipovic et al.   Nature Communications

Tim-3 and PD-1 regulate CD8+ T cell function to maintain early pregnancy in mice

(2017) Yuan-Yuan XU et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia

(2017) Ralph McGinnis et al.   NATURE GENETICS

Expression of CD226 is associated to but not required for NK cell education

(2017) Arnika K. Wagner et al.   Nature Communications

Quantification of Gestational Changes in the Uteroplacental Vascular Tree Reveals Vessel Specific Hemodynamic Roles During Pregnancy in Mice

(2016) M. Y. Rennie et al.   BIOLOGY OF REPRODUCTION

Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy

(2016) Philippa R. Kennedy et al.   JOURNAL OF IMMUNOLOGY

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Physical and neurobehavioral determinants of reproductive onset and success

(2016) Felix R Day et al.   NATURE GENETICS

Gestational food restriction decreases placental interleukin-10 expression and markers of autophagy and endoplasmic reticulum stress in murine intrauterine growth restriction

(2016) Alison Chu et al.   NUTRITION RESEARCH

Identification of suitable reference genes in the mouse placenta

(2016) María Emilia Solano et al.   PLACENTA

The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy

(2016) Selma Boulenouar et al.   Frontiers in Immunology

KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells

(2015) Malcolm J. W. Sim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

First do no harm: uterine natural killer (NK) cells in assisted reproduction

(2015) A. Moffett et al.   HUMAN REPRODUCTION

The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8+ T Cells in Response to a Lethal Poxvirus Infection

(2015) Aaron S. Rapaport et al.   IMMUNITY

Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction

(2015) Ashley Moffett et al.   IMMUNOLOGICAL REVIEWS

Composition, Development, and Function of Uterine Innate Lymphoid Cells

(2015) Jean-Marc Doisne et al.   JOURNAL OF IMMUNOLOGY

Tissue-Specific Education of Decidual NK Cells

(2015) Andrew M. Sharkey et al.   JOURNAL OF IMMUNOLOGY

AKIR Bcentromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia

(2015) Annettee Nakimuli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

A truncating PET100 variant causing fatal infantile lactic acidosis and isolated cytochrome c oxidase deficiency

(2014) Monika Oláhová et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Brain Sparing in Fetal Mice: BOLD MRI and Doppler Ultrasound Show Blood Redistribution During Hypoxia

(2014) Lindsay S Cahill et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Uterine NK cells: active regulators at the maternal-fetal interface

(2014) Ashley Moffett et al.   JOURNAL OF CLINICAL INVESTIGATION

Maternal KIR in Combination with Paternal HLA-C2 Regulate Human Birth Weight

(2014) S. E. Hiby et al.   JOURNAL OF IMMUNOLOGY

MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling

(2014) Jens Kieckbusch et al.   Nature Communications

Revisiting the Effect of Maternal Smoking during Pregnancy on Offspring Birthweight: A Quasi-Experimental Sibling Analysis in Sweden

(2013) Sol Pía Juárez et al.   PLoS One

High Frequency Ultrasound for In Vivo Pregnancy Diagnosis and Staging of Placental and Fetal Development in Mice

(2013) Adelaide Greco et al.   PLoS One

Structural Stabilization of Tissue for Embryo Phenotyping Using Micro-CT with Iodine Staining

(2013) Michael D. Wong et al.   PLoS One

Evaluation of Utero-placental and Fetal Hemodynamic Parameters Throughout Gestation in Pregnant Mice Using High-Frequency Ultrasound

(2013) Edgar Hernandez-Andrade et al.   ULTRASOUND IN MEDICINE AND BIOLOGY

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Removing technical variability in RNA-seq data using conditional quantile normalization

(2012) K. D. Hansen et al.   BIOSTATISTICS

A novel 3D mouse embryo atlas based on micro-CT

(2012) M. D. Wong et al.   DEVELOPMENT

Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude

(2012) Hong Wa Yung et al.   FASEB JOURNAL

Genome-Wide Association Scan Identifies a Risk Locus for Preeclampsia on 2q14, Near the Inhibin, Beta B Gene

(2012) Matthew P. Johnson et al.   PLoS One

Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients

(2012) Linlu Zhao et al.   BMC Pregnancy and Childbirth

LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts overall survival in untreated patients

(2011) H. Duzkale et al.   BLOOD

Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

(2011) Z. Madeja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education

(2010) N. K. Bjorkstrom et al.   BLOOD

Natural Killer Cell Education and Tolerance

(2010) Mark T. Orr et al.   CELL

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and Function of CD94-Deficient Natural Killer Cells

(2010) Mark T. Orr et al.   PLoS One

Middle versus anterior cerebral artery Doppler for the prediction of perinatal outcome and neonatal neurobehavior in term small-for-gestational-age fetuses with normal umbilical artery Doppler

(2010) D. Oros et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

(2008) P. Brodin et al.   BLOOD

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

(2008) M. Yawata et al.   BLOOD

Neurodevelopmental outcome in 2-year-old infants who were small-for-gestational age term fetuses with cerebral blood flow redistribution

(2008) E. Eixarch et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY