Review
Biochemistry & Molecular Biology
Andrei Alexandru Mircea, Mihaela Rusu, Elisa Anamaria Liehn, Octavian Bucur
Summary: This review focuses on newly developed strategies, such as vernakalant and stereotactic ablative therapy, for the treatment of arrhythmias. These therapies are important for improving the management of atrial fibrillation and ventricular tachycardia, offering higher success rates and lower costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Tian Zou, Qingxing Chen, Chaofeng Chen, Guijian Liu, Yunlong Ling, Yang Pang, Ye Xu, Kuan Cheng, Wenqing Zhu, Ruxing Wang, Lingling Qian, Junbo Ge
Summary: This study found that moricizine can prevent atrial fibrillation (AF) by inhibiting enhanced late sodium current (INaL) and reducing calcium/calmodulin-dependent protein kinase-II (CaMKII) activation. This provides new evidence for the therapeutic mechanism of moricizine as an anti-arrhythmia drug.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Pei-pei Zhang, Zhao-fu Guo, Pei-hua Zhang, Zhi-pei Liu, Lv Song, Ze-fu Zhang, Yu-zhong Jia, Zhen-zhen Cao, Ji-hua Ma
Summary: The study showed that Eleutheroside B (EB) inhibited atrial fibrillation by suppressing late sodium current (I-NaL) and had effects on cardiac electrophysiology. These findings provide a pharmacological basis for the potential clinical application of EB.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Xiaoyan Liu, Lu Ren, Shandong Yu, Gang Li, Pengkang He, Qiaomei Yang, Xiaohong Wei, Phung N. Thai, Lin Wu, Yong Huo
Summary: This study reveals that late INa, in association with the activation of CaMKII, potentiates ss-adrenergic stimulation-induced AF in patients with structural heart diseases. The inhibition of both late INa and CaMKII exerts synergistic anti-arrhythmic effects, suppressing atrial arrhythmic activities associated with catecholaminergic activation.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Molly O'Reilly, Laura C. Sommerfeld, C. O'Shea, S. Broadway-Stringer, S. Andaleeb, J. S. Reyat, S. N. Kabir, D. Stastny, A. Malinova, D. Delbue, L. Fortmueller, K. Gehmlich, D. Pavlovic, B. Skryabin, A. P. Holmes, P. Kirchhof, L. Fabritz
Summary: This study found that the point mutation M1875T in the SCN5A gene is associated with familial AF. A new mouse model was used to show that this mutation causes gain-of-function of the cardiac sodium channel, resulting in increased atrial excitability.
Review
Cardiac & Cardiovascular Systems
Louisa O'Neill, Benjamin De Becker, Maarten De Smet, Jean-Benoit Le Polain De Waroux, Rene Tavernier, Mattias Duytschaever, Sebastien Knecht
Summary: Recurrent atrial tachycardia is a common phenomenon after catheter ablation for AF, with gap-related macro re-entrant atrial tachycardia being the dominant mechanism. The optimal ablation strategy and procedural endpoint for multiple inducible ATs after ablation of the clinical AT are still unclear, but ensuring durable linear block and PV isolation may be sufficient for preventing further AT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Edouard Gitenay, Clement Bars, Michel Bremondy, Anis Ayari, Nicolas Maillot, Florian Baptiste, Antonio Taormina, Aicha Fofana, Sabrina Siame, Jerome Kalifa, Julien Seitz
Summary: The study showed that localized AT during persistent AF ablation procedures originates within dispersion regions but remote from the closest ablation lesion. This suggests that AT may represent a stabilized manifestation of co-existing AF drivers rather than being induced by ablation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shingo Maeda, Masahiko Goya, Yasuhiro Shirai, Atsuhiko Yagishita, Susumu Tao, Jackson Jeikai Liang, Ruben Casado Arroyo, Yoshihide Takahashi, Mihoko Kawabata, Tetsuo Sasano, Kenzo Hirao
Summary: This study aimed to identify novel predictors of effective atrial anti-tachycardia pacing (A-ATP) for terminating atrial fibrillation (AF) in patients undergoing catheter ablation. The results showed that simultaneous biatrial A-ATP from the right atrium (RA) and coronary sinus (CS) could terminate AF in patients with paroxysmal AF. The predictors for successful termination included longer AF cycle length and higher AF stability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Martina Nesti, Fabiana Luca, David Duncker, Francesco De Sensi, Katarzyna Malaczynska-Rajpold, Jonathan M. Behar, Victor Waldmann, Ahmed Ammar, Gianluca Mirizzi, Rodrigue Garcia, Ahran Arnold, Evgeny N. Mikhaylov, Jedrzej Kosiuk, Luigi Sciarra
Summary: Our survey indicates that the management of anti-thrombotic therapy surrounding left-sided endocardial ablation of patients without other indications for anti-thrombotic therapy is highly variable. Further studies are necessary to evaluate the safest approach to these procedures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jean-Baptiste Guichard, Feng Xiong, Xiao-Yan Qi, Nathalie L'Heureux, Roddy Hiram, Jiening Xiao, Patrice Naud, Jean-Claude Tardif, Antoine Da Costa, Stanley Nattel
Summary: This study assessed the specific contributions of atrial fibrillation-related atrial arrhythmia vs. associated ventricular arrhythmia to remodeling. The results showed that both atrial tachyarrhythmia and rapid ventricular response during AF produce distinct atrial remodelling, providing new insights into AF-related remodeling and ventricular rate-control considerations.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Islam Kourampi, Maria Katsioupa, Evangelos Oikonomou, Vasiliki Tsigkou, Georgios Marinos, Athina Goliopoulou, Ourania Katsarou, Konstantinos Kalogeras, Panagiotis Theofilis, Aikaterini Tsatsaragkou, Gerasimos Siasos, Dimitris Tousoulis, Manolis Vavuranakis
Summary: Heart failure is a detrimental clinical syndrome. Ranolazine, a medication that inhibits late sodium current and reduces calcium overload, has potential benefits in treating heart failure by improving energy utilization and ion channel regulation. Further research is needed to fully understand its therapeutic mechanisms.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karl-Heinz Kuck, Dmitry S. Lebedev, Evgeny N. Mikhaylov, Alexander Romanov, Laszlo Geller, Oskars Kalejs, Thomas Neumann, Karapet Davtyan, Young Keun On, Sergey Popov, Maria Grazia Bongiorni, Michael Schlueter, Stephan Willems, Feifan Ouyang
Summary: The study indicates that radiofrequency ablation is more effective than antiarrhythmic drug therapy in delaying the progression from paroxysmal to persistent atrial fibrillation. Patients aged 65 and above may have an increased risk of progressing to persistent atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Dragan Opacic, Arne van Hunnik, Stef Zeemering, Arvinder Dhalla, Luiz Belardinelli, Ulrich Schotten, Sander Verheule
Summary: This study aimed to investigate the electrophysiological effects of ranolazine in atria with AF-induced electrical remodeling, finding that it affected atrial electrophysiological parameters but was not effective in restoring sinus rhythm. No adverse ventricular arrhythmic events were observed during ranolazine infusion.
Article
Medicine, General & Internal
Armin Luik, Kerstin Schmidt, Annika Haas, Laura Unger, Panagiotis Tzamalis, Bernd Brueggenjuergen
Summary: The treatment of atrial tachycardia following catheter ablation of atrial fibrillation is often challenging, but new ablation approaches have shown promising results. However, long-term data on the freedom from any atrial tachycardia or any arrhythmia are still limited. This study presents 12-month success and mean 30 month follow-up data of catheter ablation of left atrial tachycardia, demonstrating high long-term clinical success rates with individual ablation strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Prakash Harikrishnan, Tanush Gupta, Dhaval Kolte, Chandrasekar Palaniswamy, Sahil Khera, Wilbert Aronow, Marjan Mujib, Diwakar Jain, Sachin Sule, Gregg Fonarow, Ali Ahmed, William Frishman, Howard Cooper, Jason Jacobson, Sei Iwai, Julio Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Prakash Harikrishnan, Tanush Gupta, Dhaval Kolte, Chandrasekar Palaniswamy, Sahil Khera, Wilbert Aronow, Marjan Mujib, Kathir Subramanian, Diwakar Jain, Sachin Sule, Gregg Fonarow, Ali Ahmed, Howard Cooper, Jason Jacobson, Sei Iwai, Julio Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Prakash Harikrishnan, Tanush Gupta, Dhaval Kolte, Chandrasekar Palaniswamy, Sahil Khera, Wilbert Aronow, Marjan Mujib, Nivas Balasubramaniyam, Diwakar Jain, Sachin Sule, Gregg Fonarow, Ali Ahmed, Howard Cooper, Jason Jacobson, Sei Iwai, Julio Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Nivas Balasubramaniyam, Prakash Harikrishnan, Tanush Gupta, Wilbert S. Aronow, Chandrasekar Palaniswamy, Robert Timmermans, Hasan Ahmad, Howard A. Cooper, Julio A. Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Tanush Gupta, Prakash Harikrishnan, Dhaval Kolte, Sahil Khera, Chandrasekar Palaniswamy, Wilbert Aronow, Marjan Mujib, Diwakar Jain, Sachin Sule, Ali Ahmed, Gregg Lanier, Howard Cooper, Gregg Fonarow, Julio Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Meeting Abstract
Cardiac & Cardiovascular Systems
Tanush Gupta, Prakash Harikrishnan, Dhaval Kolte, Sahil Khera, Wilbert Aronow, Marjan Mujib, Chandrasekar Palaniswamy, Ali Ahmed, Diwakar Jain, Sachin Sule, Gregg Lanier, Howard Cooper, Gregg Fonarow, Julio Panza
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2015)
Article
Health Care Sciences & Services
Christopher Nabors, Dhruv Patel, Sahil Khera, Dhaval Kolte, Ridhi Gupta, Nivas Balasubramaniyam, Samir Ambrale, Nikhil Mukhi, Rajat Lamba, Vidya Ramachandraiah, Kathir Subramanian, Rashid Syed, Kyung Hun Nam, Inderpreet Kaur Dardi, Shoma Bommena, Varun Mittal, Stephen J. Peterson
JOURNAL OF PATIENT SAFETY
(2015)
Article
Pharmacology & Pharmacy
Christopher Nabors, Sahil Khera, Leanne Forman, Dhaval Kolte, Varun Mittal, Abhishek Marballi, Sahil Agrawal, Rahul Pawar, Daniel O'Connell, Sara M. Afanador, Krishna Kolandaivel, Savneek Chugh, Stephen J. Peterson
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Tanush Gupta, Neha Paul, Chandrasekar Palaniswamy, Nivas Balasubramaniyam, Wilbert S. Aronow, Dhaval Kolte, Sahil Khera, Amar B. Shah, Alan Gass
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Chaitanya Iragavarapu, Tanush Gupta, Savneek S. Chugh, Wilbert S. Aronow, William H. Frishman
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Tanush Gupta, Marjan Mujib, Pallak Agarwal, Priya Prakash, Anjali Garg, Nisha Sharma, Wilbert S. Aronow, Christopher Nabors
AMERICAN JOURNAL OF THERAPEUTICS
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Sahil Khera, George Dangas
Summary: Transcatheter aortic valve replacement using current commercially available devices in the United States for aortic regurgitation is considered off label use and may result in unfavorable outcomes compared to typical aortic stenosis patients. Evolving valve platforms, including active leaflet fixation, may be more suitable for transcatheter management of pure aortic regurgitation, and clinical investigation is ongoing.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Letter
Cardiac & Cardiovascular Systems
Sahil Khera, Anoop N. Koshy, Gilbert H. L. Tang, Pedro Moreno, Roxana Mehran, George D. Dangas, David Bronster, Annapoorna S. Kini, Michael Fara, Samin K. Sharma
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
