A synonymous mutation in IGF-1 impacts the transcription and translation process of gene expression

Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions

(2020) Zhiquan Liu et al.   BMC BIOLOGY

DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture

(2019) Tingjun Liu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Translation affects mRNA stability in a codon-dependent manner in human cells

(2019) Qiushuang Wu et al.   eLife

Highly efficient base editing with expanded targeting scope using SpCas9‐NG in rabbits

(2019) Zhiquan Liu et al.   FASEB JOURNAL

Insulin-like growth factor-1 signaling in cardiac aging

(2018) Wang-Soo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice

(2018) Georgios Vassilakos et al.   FASEB JOURNAL

Porcine IGF1 synonymous mutation alter gene expression and protein binding affinity with IGF1R

(2018) Yunyun Cheng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

(2018) Luke W Koblan et al.   NATURE BIOTECHNOLOGY

Selection for growth rate and body size have altered the expression profiles of somatotropic axis genes in chickens

(2018) Junjing Jia et al.   PLoS One

Gene expression, nucleotide composition and codon usage bias of genes associated with human Y chromosome

(2017) Monisha Nath Choudhury et al.   GENETICA

MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1/2 and PI3K-Akt pathway under severe hypoxia

(2017) Yongqiang Sha et al.   LIFE SCIENCES

GH/IGF-I/insulin system in centenarians

(2017) Giovanni Vitale et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level

(2017) Siyu Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

(2017) Y Bill Kim et al.   NATURE BIOTECHNOLOGY

Diversification of the insulin-like growth factor 1 gene in mammals

(2017) Peter Rotwein   PLoS One

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

(2017) Holly A. Rees et al.   Nature Communications

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

(2017) Alexis C. Komor et al.   Science Advances

Efficient dual sgRNA-directed large gene deletion in rabbit with CRISPR/Cas9 system

(2016) Yuning Song et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Growth factors, aging and age-related diseases

(2016) Priya Balasubramanian et al.   GROWTH HORMONE & IGF RESEARCH

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Targeted AID-mediated mutagenesis (TAM) enables efficient genomic diversification in mammalian cells

(2016) Yunqing Ma et al.   NATURE METHODS

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering

(2016) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Expression Profiles of IGF-1R Gene and Polymorphisms of its Regulatory Regions in Different Pig Breeds

(2016) Yunyun Cheng et al.   PROTEIN JOURNAL

Roles for Synonymous Codon Usage in Protein Biogenesis

(2015) Julie L. Chaney et al.   Annual Review of Biophysics

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

RNA structure replaces the need for U2AF2 in splicing

(2015) Chien-Ling Lin et al.   GENOME RESEARCH

Cyp26b1 within the growth plate regulates bone growth in juvenile mice

(2014) Yoshiki Minegishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Silent Mutations Make Some Noise

(2014) Siyuan Zheng et al.   CELL

Characterization and prevalence of severe primary IGF1 deficiency in a large cohort of French children with short stature

(2014) R Teissier et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Toxicity of selenium nanoparticles in male Sprague–Dawley rats at supranutritional and nonlethal levels

(2014) Yudan He et al.   LIFE SCIENCES

Exposing synonymous mutations

(2014) Ryan C. Hunt et al.   TRENDS IN GENETICS

MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

(2013) King Leung Fung et al.   CANCER RESEARCH

The silent codon change I507-ATC→ATT contributes to the severity of the ΔF508 CFTR channel dysfunction

(2013) Ahmed Lazrak et al.   FASEB JOURNAL

The genetic code as expressed through relationships between mRNA structure and protein function

(2013) David M. Mauger et al.   FEBS LETTERS

Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice

(2012) Matilda H.-C. Sheng et al.   BONE

Healthy Aging: Is Smaller Better? – A Mini-Review

(2012) Andrzej Bartke   GERONTOLOGY

Silent Substitutions Predictably Alter Translation Elongation Rates and Protein Folding Efficiencies

(2012) Paige S. Spencer et al.   JOURNAL OF MOLECULAR BIOLOGY

The IGF1 small dog haplotype is derived from Middle Eastern grey wolves

(2010) Melissa M Gray et al.   BMC BIOLOGY

Increased incidence of rare codon clusters at 5' and 3' gene termini:implications for function

(2010) Thomas F Clarke et al.   BMC GENOMICS

Subtle discrepancies of SF2/ASF ESE sequence motif among human tissues: A computational approach

(2010) Olfa Siala et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The insulin-like growth factor (IGF)-I E-peptides are required for isoform-specific gene expression and muscle hypertrophy after local IGF-I production

(2010) Elisabeth R. Barton et al.   JOURNAL OF APPLIED PHYSIOLOGY

A Synonymous Single Nucleotide Polymorphism in ΔF508CFTRAlters the Secondary Structure of the mRNA and the Expression of the Mutant Protein

(2010) Rafal A. Bartoszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGF-1 and bone: New discoveries from mouse models

(2010) Shoshana Yakar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

(2010) Sebastio Perrini et al.   JOURNAL OF ENDOCRINOLOGY

Synonymous but not the same: the causes and consequences of codon bias

(2010) Joshua B. Plotkin et al.   NATURE REVIEWS GENETICS

Synonymous codon usage influences the local protein structure observed

(2010) Rhodri Saunders et al.   NUCLEIC ACIDS RESEARCH

Control of translation efficiency in yeast by codon-anticodon interactions

(2010) D. P. Letzring et al.   RNA

Rare Codons Cluster

(2008) Thomas F. Clarke et al.   PLoS One

Splicing fidelity, enhancers, and disease

(2007) Amanda et al.   Frontiers in Bioscience-Landmark