IGF-1 and bone: New discoveries from mouse models

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

Elevated serum levels of IGF-1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF-1

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Elevated serum IGF-1 levels synergize PTH action on the skeleton only when the tissue IGF-1 axis is intact

(2010) Sebastien Elis et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sex-specific regulation of body size and bone slenderness by the acid labile subunit

(2010) Hayden-William Courtland et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Heterozygous Mutation within a Kinase-Conserved Motif of the Insulin-Like Growth Factor I Receptor Causes Intrauterine and Postnatal Growth Retardation

(2010) Tassilo Kruis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Elevated Levels of Insulin-Like Growth Factor (IGF)-I in Serum Rescue the Severe Growth Retardation of IGF-I Null Mice

(2009) YingJie Wu et al.   ENDOCRINOLOGY

Human Acid-Labile Subunit Deficiency: Clinical, Endocrine and Metabolic Consequences

(2009) Horacio M. Domené et al.   HORMONE RESEARCH

Serum IGF-1 Determines Skeletal Strength by Regulating Subperiosteal Expansion and Trait Interactions

(2009) Shoshana Yakar et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two Short Children Born Small for Gestational Age with Insulin-Like Growth Factor 1 Receptor Haploinsufficiency Illustrate the Heterogeneity of Its Phenotype

(2009) Wietske A. Ester et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Familial Short Stature Caused by Haploinsufficiency of the Insulin-Like Growth Factor I Receptor due to Nonsense-Mediated Messenger Ribonucleic Acid Decay

(2009) Peng Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis

(2009) Victoria E DeMambro et al.   JOURNAL OF ENDOCRINOLOGY

Fourier Transform Infrared Imaging Microspectroscopy and Tissue-Level Mechanical Testing Reveal Intraspecies Variation in Mouse Bone Mineral and Matrix Composition

(2008) Hayden-William Courtland et al.   CALCIFIED TISSUE INTERNATIONAL

Gender-Specific Changes in Bone Turnover and Skeletal Architecture inIgfbp-2-Null Mice

(2008) V. E. DeMambro et al.   ENDOCRINOLOGY

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

(2008) Shoshana Yakar et al.   FASEB JOURNAL

Phenotypic Integration Among Trabecular and Cortical Bone Traits Establishes Mechanical Functionality of Inbred Mouse Vertebrae

(2008) Steven M Tommasini et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Successful Long-Term Growth Hormone Therapy in a Girl with Haploinsufficiency of the Insulin-Like Growth Factor-I Receptor due to a Terminal 15q26.2->qter Deletion Detected by Multiplex Ligation Probe Amplification

(2008) Marie J. E. Walenkamp et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activityin Vivo

(2008) Yun Ning et al.   MOLECULAR ENDOCRINOLOGY

The hormonal action of IGF1 in postnatal mouse growth

(2008) E. Stratikopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

(2008) H. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA