TOMM40 RNA Transcription in Alzheimer’s Disease Brain and Its Implication in Mitochondrial Dysfunction

Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

(2021) Stephanie Y Yang et al.   GENOME RESEARCH

Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals

(2021) Xiaomin Liu et al.   AGING CELL

Splicing-associated chromatin signatures: a combinatorial and position-dependent role for histone marks in splicing definition

(2021) E. Agirre et al.   Nature Communications

Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease

(2020) Eun-Gyung Lee et al.   PLoS One

Evaluation of mitochondrial DNA copy number estimation techniques

(2020) Ryan J. Longchamps et al.   PLoS One

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

(2020) Christina A. Castellani et al.   MITOCHONDRION

Alterations in mitochondrial dynamic-related genes in the peripheral blood of Alzheimer’s disease patients

(2020) Nattaporn Pakpian et al.   Current Alzheimer Research

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry

(2020) Elizabeth E. Blue et al.   JAMA Network Open

Mitochondrial DNA copy number in human disease: the more the better?

(2020) Roberta Filograna et al.   FEBS LETTERS

Assessment of Racial Disparities in Biomarkers for Alzheimer Disease

(2019) John C. Morris et al.   JAMA Neurology

The role of 3D genome organization in development and cell differentiation

(2019) Hui Zheng et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses

(2018) Anatoliy I. Yashin et al.   EXPERIMENTAL GERONTOLOGY

Gene Expression Profiling of Peripheral Blood Leukocytes Shows Consistent Longitudinal Downregulation of TOMM40 and Upregulation of KIR2DL5A, PLOD1, and SLC2A8 Among Fast Progressors in Early Alzheimer's Disease

(2018) Mei Sian Chong et al.   JOURNAL OF ALZHEIMERS DISEASE

Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease

(2018) Thea Heinemeyer et al.   DNA AND CELL BIOLOGY

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations

(2018) Farid Rajabli et al.   PLoS Genetics

Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast

(2017) Vahid Aslanzadeh et al.   GENOME RESEARCH

TOMM40 and APOE Gene Expression and Cognitive Decline in Japanese Alzheimer’s Disease Subjects

(2017) Ayano Mise et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of human short introns

(2017) Emmanuel L. Abebrese et al.   PLoS One

Multiple SNPs Within and Surrounding the Apolipoprotein E Gene Influence Cerebrospinal Fluid Apolipoprotein E Protein Levels

(2017) Lynn M. Bekris et al.   JOURNAL OF ALZHEIMERS DISEASE

Metabolic Characterization of Intact Cells Reveals Intracellular Amyloid Beta but Not Its Precursor Protein to Reduce Mitochondrial Respiration

(2017) Patrick M. Schaefer et al.   PLoS One

Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease

(2016) Allen Roses et al.   Alzheimers & Dementia

Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process

(2016) Giovanna Cenini et al.   MOLECULAR BIOLOGY OF THE CELL

Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

(2015) G Davies et al.   MOLECULAR PSYCHIATRY

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

(2015) Kristen Fortney et al.   PLoS Genetics

The cis-regulatory effect of an Alzheimer’s disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes

(2014) Colton Linnertz et al.   Alzheimers & Dementia

APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba

(2014) Hugh C. Hendrie et al.   INTERNATIONAL PSYCHOGERIATRICS

Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study

(2014) Chenan Zhang et al.   NEUROBIOLOGY OF AGING

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

(2014) Gary W. Beecham et al.   PLoS Genetics

TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial

(2013) Allen D. Roses et al.   Alzheimers & Dementia

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Changes in mitochondrial function are pivotal in neurodegenerative and psychiatric disorders: How important is BDNF?

(2013) A Markham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

Using Genetics to Enable Studies on the Prevention of Alzheimer’s Disease

(2012) D G Crenshaw et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals

(2012) Yiran Guo et al.   HUMAN MOLECULAR GENETICS

Downregulation of TOMM40 expression in the blood of Alzheimer disease subjects compared with matched controls

(2012) Tih-Shih Lee et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

(2011) Joris Deelen et al.   AGING CELL

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

(2011) Rita PS Middelberg et al.   BMC Medical Genetics

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE

(2011) Lynn M Bekris et al.   JOURNAL OF HUMAN GENETICS

Genetic variation at a single locus and age of onset for Alzheimer's disease

(2010) Michael W. Lutz et al.   Alzheimers & Dementia

Matching ATP supply and demand in mammalian heart

(2010) Yael Yaniv et al.   Annals of the New York Academy of Sciences

An Inherited Variable Poly-T Repeat Genotype in TOMM40 in Alzheimer Disease

(2010) Allen D. Roses   ARCHIVES OF NEUROLOGY

Mitochondria and Neuroplasticity

(2010) Aiwu Cheng et al.   ASN Neuro

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

(2010) Dimitrios Kapogiannis et al.   LANCET NEUROLOGY

APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure

(2009) Lynn M. Bekris et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese

(2009) Norihiro Takei et al.   GENOMICS

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

LDL-cholesterol concentrations: a genome-wide association study

(2008) Manjinder S Sandhu et al.   LANCET

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE