Molecular Signaling Mechanisms and Function of Natriuretic Peptide Receptor-A in the Pathophysiology of Cardiovascular Homeostasis

Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs

(2020) Kiran K. Arise et al.   Scientific Reports

Depletion of cyclic‐GMP levels and inhibition of cGMP‐dependent protein kinase activate p21 Cip1 /p27 Kip1 pathways and lead to renal fibrosis and dysfunction

(2020) Subhankar Das et al.   FASEB JOURNAL

Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart

(2020) Joyce C.K. Man et al.   CIRCULATION RESEARCH

Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development

(2019) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

C-type natriuretic peptide co-ordinates cardiac structure and function

(2019) Amie J Moyes et al.   EUROPEAN HEART JOURNAL

CRRL269

(2019) Yang Chen et al.   CIRCULATION RESEARCH

ARNi: A Novel Approach to Counteract Cardiovascular Diseases

(2019) Massimo Volpe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice

(2019) Ramu Periyasamy et al.   PEPTIDES

Atrial Natriuretic Peptide: A Molecular Target of Novel Therapeutic Approaches to Cardio-Metabolic Disease

(2019) Valentina Cannone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking

(2019) Indra Mani et al.   CELLULAR SIGNALLING

Genetic Ablation and Guanylyl Cyclase/Natriuretic Peptide Receptor-A: Impact on the Pathophysiology of Cardiovascular Dysfunction

(2019) Kailash N. Pandey   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Blood Pressure-Associated Genetic Variants in the Natriuretic Peptide Receptor 1 Gene Modulate Guanylate Cyclase Activity

(2019) Sara Vandenwijngaert et al.   Circulation-Genomic and Precision Medicine

Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP

(2019) Shawn H. Reginauld et al.   JACC-Heart Failure

Natriuretic Peptides in Cardiovascular and Metabolic Crosstalk

(2018) Jens Jordan et al.   HYPERTENSION

Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide

(2018) Tomoko Ichiki et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Atrial and brain natriuretic peptides: Hormones secreted from the heart

(2018) Yasuaki Nakagawa et al.   PEPTIDES

Natriuretic Peptide Deficiency—When There Is Too Little of a Good Thing

(2018) Thomas J. Wang   JAMA Cardiology

Molecular and Genetic Aspects of Guanylyl Cyclase Natriuretic Peptide Receptor-A in Regulation of Blood Pressure and Renal Function

(2018) Kailash N. Pandey   PHYSIOLOGICAL GENOMICS

Natriuretic peptides in heart failure: Current achievements and future perspectives

(2018) Massimo Volpe et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic HypertensionNovelty and Significance

(2017) Bryan Williams et al.   HYPERTENSION

Clathrin-dependent internalization, signaling, and metabolic processing of guanylyl cyclase/natriuretic peptide receptor-A

(2017) Naveen K. Somanna et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: a metabolic link with the cardiac natriuretic pathway

(2016) M. Bordicchia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Natriuretic peptide control of energy balance and glucose homeostasis

(2016) Marine Coué et al.   BIOCHIMIE

Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1

(2016) Anagha Sen et al.   FEBS Journal

Retinoic acid and sodium butyrate suppress the cardiac expression of hypertrophic markers and proinflammatory mediators in Npr1 gene-disrupted haplotype mice

(2016) Umadevi Subramanian et al.   PHYSIOLOGICAL GENOMICS

Designer Natriuretic Peptides

(2016) Candace Y. W. Lee et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Subcellular trafficking of guanylyl cyclase/natriuretic peptide receptor-A with concurrent generation of intracellular cGMP

(2015) I. Mani et al.   BIOSCIENCE REPORTS

Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

(2015) Marine Coué et al.   DIABETES

Novel Diuretic Strategies for the Treatment of Heart Failure in Japan

(2014) Kaoru Dohi et al.   CIRCULATION JOURNAL

Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in WhitesCLINICAL PERSPECTIVE

(2014) Naveen L. Pereira et al.   Circulation-Cardiovascular Genetics

Genetically Altered Mutant Mouse Models of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Exhibit the Cardiac Expression of Proinflammatory Mediators in a Gene-Dose-Dependent Manner

(2014) Elangovan Vellaichamy et al.   ENDOCRINOLOGY

Natriuretic peptides and cardio-renal disease

(2014) Massimo Volpe   INTERNATIONAL JOURNAL OF CARDIOLOGY

Histone Deacetylase Inhibitors Modulate the Transcriptional Regulation of Guanylyl Cyclase/Natriuretic Peptide Receptor-A Gene

(2014) Prerna Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High natriuretic peptide levels and low DBP

(2014) Speranza Rubattu et al.   JOURNAL OF HYPERTENSION

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome

(2014) Nina Schlueter et al.   PHARMACOLOGY & THERAPEUTICS

Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?

(2014) Marcelo Roberto Choi et al.   Biomed Research International

Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca2+ release, and activation of protein kinase C

(2014) Kailash N. Pandey   Frontiers in Molecular Neuroscience

Natriuretic peptides and fat metabolism

(2013) Cedric Moro   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Natriuretic peptides in cardiovascular diseases: current use and perspectives

(2013) M. Volpe et al.   EUROPEAN HEART JOURNAL

Relative Atrial Natriuretic Peptide Deficiency and Inadequate Renin and Angiotensin II Suppression in Obese Hypertensive Men

(2013) Camilla L. Asferg et al.   HYPERTENSION

Atrial Natriuretic Peptide Affects Cardiac Remodeling, Function, Heart Failure, and Survival in a Mouse Model of Dilated Cardiomyopathy

(2013) Dong Wang et al.   HYPERTENSION

Urodilatin regulates renal dopamine metabolism

(2013) Marcelo R. Choi et al.   JOURNAL OF NEPHROLOGY

Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts

(2013) Arumugam Parthasarathy et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Complexity of molecular forms of B-type natriuretic peptide in heart failure

(2012) Toshio Nishikimi et al.   HEART

Natriuretic peptides enhance the oxidative capacity of human skeletal muscle

(2012) Stefan Engeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

Interactive roles of NPR1 gene-dosage and salt diets on cardiac angiotensin II, aldosterone and pro-inflammatory cytokines levels in mutant mice

(2012) Di Zhao et al.   JOURNAL OF HYPERTENSION

Human Hypertension Is Characterized by a Lack of Activation of the Antihypertensive Cardiac Hormones ANP and BNP

(2012) Fima Macheret et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes the vascular endothelial growth factor-stimulated MAPKs and downstream effectors AP-1 and CREB in mouse mesangial cells

(2012) Satyabha Tripathi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Atrial Natriuretic Peptide and Adiponectin Interactions in Man

(2012) Andreas L. Birkenfeld et al.   PLoS One

Natriuretic peptide system: an overview of studies using genetically engineered animal models

(2011) Ichiro Kishimoto et al.   FEBS Journal

Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase

(2011) Kunio S. Misono et al.   FEBS Journal

The functional genomics of guanylyl cyclase/natriuretic peptide receptor-A: Perspectives and paradigms

(2011) Kailash N. Pandey   FEBS Journal

Cardiac Natriuretic Peptides: From Basic Discovery to Clinical Practice

(2010) Salim Hayek et al.   Cardiovascular Therapeutics

Human Brown Adipose Tissue

(2010) Sven Enerbäck   Cell Metabolism

Targeted Disruption of Guanylyl Cyclase-A/Natriuretic Peptide Receptor-A Gene Provokes Renal Fibrosis and Remodeling in Null Mutant Mice: Role of Proinflammatory Cytokines

(2010) Subhankar Das et al.   ENDOCRINOLOGY

Roles of atrial natriuretic peptide and its therapeutic use

(2010) Yoshihiko Saito   Journal of Cardiology

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

(2010) Luis Miguel Ruilope et al.   LANCET

Biochemical tissue-specific injury markers of the heart and brain in postpartum cord blood

(2009) Rafal D. Kocylowski et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides

(2009) Takeshi Tokudome et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development

(2009) Nicola J.A. Scott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1receptor gene expression inNpr1gene-disrupted mice

(2009) Kailash N Pandey et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity

(2009) Kazutoshi Miyashita et al.   DIABETES

The natriuretic peptide/guanylyl cyclase–A system functions as a stress-responsive regulator of angiogenesis in mice

(2009) Michaela Kuhn et al.   JOURNAL OF CLINICAL INVESTIGATION

Natriuretic Peptides Enhance the Production of Adiponectin in Human Adipocytes and in Patients With Chronic Heart Failure

(2009) Osamu Tsukamoto et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif

(2009) Kailash N. Pandey   MOLECULAR AND CELLULAR BIOCHEMISTRY

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes

(2008) Masanori Mitsuishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans

(2008) A. L. Birkenfeld et al.   DIABETES

Design, Synthesis, and Actions of a Novel Chimeric Natriuretic Peptide: CD-NP

(2008) Ondrej Lisy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Emerging roles of natriuretic peptides and their receptors in pathophysiology of hypertension and cardiovascular regulation

(2008) Kailash N. Pandey   Journal of the American Society of Hypertension

Urodilatin and dopamine: A new interaction in the kidney

(2008) Marisa R. Citarella et al.   REGULATORY PEPTIDES

Better pharmacotherapy for schizophrenia: What does the future hold?

(2008) Michael A. Webber et al.   Current Psychiatry Reports

Atrial natriuretic peptide gene promoter polymorphism is associated with left ventricular hypertrophy in hypertension

(2007) Hao Xue et al.   CLINICAL SCIENCE

Therapeutic Potential of Atrial Natriuretic Peptide Administration on Peripheral Arterial Diseases

(2007) Kwijun Park et al.   ENDOCRINOLOGY