Molecular Implications of Natriuretic Peptides in the Protection from Hypertension and Target Organ Damage Development

The T2238C Human Atrial Natriuretic Peptide Molecular Variant and the Risk of Cardiovascular Diseases

(2018) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat

(2018) Speranza Rubattu et al.   JOURNAL OF HYPERTENSION

Molecular mechanisms underlying the neuroprotective role of atrial natriuretic peptide in experimental acute ischemic stroke

(2018) Mikahela A. López-Morales et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle

(2017) Meixia Ren et al.   HUMAN MOLECULAR GENETICS

Identification and functional analysis of CORIN variants in hypertensive patients

(2017) Yue Zhang et al.   HUMAN MUTATION

Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic HypertensionNovelty and Significance

(2017) Bryan Williams et al.   HYPERTENSION

T2238C Atrial Natriuretic Peptide Gene Variant and the Response to Antiplatelet Therapy in Stable Ischemic Heart Disease Patients

(2017) Teresa Strisciuglio et al.   Journal of Cardiovascular Translational Research

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

(2017) Lasse Folkersen et al.   PLoS Genetics

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General PopulationCLINICAL PERSPECTIVE

(2017) Perttu P. Salo et al.   Circulation-Cardiovascular Genetics

An NPPB Promoter Polymorphism Associated With Elevated N‐Terminal pro–B‐Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality

(2017) Sara B. Seidelmann et al.   Journal of the American Heart Association

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

(2017) Roberto Carnevale et al.   Scientific Reports

Novel Insights Into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation

(2016) Massimo Volpe et al.   CIRCULATION RESEARCH

Localization of corin and atrial natriuretic peptide expression in human renal segments

(2016) L. Dong et al.   CLINICAL SCIENCE

Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome

(2016) Åsa Johansson et al.   HUMAN MOLECULAR GENETICS

Effects of Sacubitril/Valsartan (LCZ696) on Natriuresis, Diuresis, Blood Pressures, and NT-proBNP in Salt-Sensitive HypertensionNovelty and Significance

(2016) Tzung-Dau Wang et al.   HYPERTENSION

LCZ696, Angiotensin II Receptor-Neprilysin Inhibitor, Ameliorates High-Salt-Induced Hypertension and Cardiovascular Injury More Than Valsartan Alone

(2015) Hiroaki Kusaka et al.   AMERICAN JOURNAL OF HYPERTENSION

Genome-Wide Association Analysis of Plasma B–Type Natriuretic Peptide in BlacksCLINICAL PERSPECTIVE

(2015) Solomon K. Musani et al.   Circulation-Cardiovascular Genetics

Correlation between natriuretic peptide receptor C (NPR3) gene polymorphisms and hypertension in the Dai people of China

(2015) H. Sun et al.   GENETICS AND MOLECULAR RESEARCH

B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced SurvivalNovelty and Significance

(2015) Sara J. Holditch et al.   HYPERTENSION

PCSK6-mediated corin activation is essential for normal blood pressure

(2015) Shenghan Chen et al.   NATURE MEDICINE

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro

(2015) R Stanzione et al.   Cell Death & Disease

Novel Genes Affecting Blood Pressure Detected Via Gene-Based Association Analysis

(2015) H. Zhang et al.   G3-Genes Genomes Genetics

Genome-Wide Association Analysis of Plasma B–Type Natriuretic Peptide in BlacksCLINICAL PERSPECTIVE

(2015) Solomon K. Musani et al.   Circulation-Cardiovascular Genetics

Chronic Treatment with Atrial Natriuretic Peptide in Spontaneously Hypertensive Rats: Beneficial Renal Effects and Sex Differences

(2015) Mariana Romero et al.   PLoS One

Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in WhitesCLINICAL PERSPECTIVE

(2014) Naveen L. Pereira et al.   Circulation-Cardiovascular Genetics

Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides

(2014) Fumiki Yoshihara et al.   Clinical and Experimental Nephrology

Atrial natriuretic peptide gene variants and circulating levels: implications in cardiovascular diseases

(2014) Speranza Rubattu et al.   CLINICAL SCIENCE

Efficacy and Safety of LCZ696, a First-in-Class Angiotensin Receptor Neprilysin Inhibitor, in Asian Patients With Hypertension

(2014) Kazuomi Kario et al.   HYPERTENSION

Corin Mutations K317E and S472G from Preeclamptic Patients Alert Zymogen Activation and Cell Surface Targeting

(2014) Ningzheng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current role of neprilysin inhibitors in hypertension and heart failure

(2014) Thomas G. von Lueder et al.   PHARMACOLOGY & THERAPEUTICS

The C2238/αANP Variant Is a Negative Modulator of Both Viability and Function of Coronary Artery Smooth Muscle Cells

(2014) Speranza Rubattu et al.   PLoS One

C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling

(2013) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

The Atrial Natriuretic Peptide Genetic Variant rs5068 Is Associated With a Favorable Cardiometabolic Phenotype in a Mediterranean Population

(2013) Valentina Cannone et al.   DIABETES CARE

Natriuretic peptides in cardiovascular diseases: current use and perspectives

(2013) M. Volpe et al.   EUROPEAN HEART JOURNAL

Atrial Natriuretic Peptide Genetic Variant rs5065 and Risk for Cardiovascular Disease in the General Community

(2013) Valentina Cannone et al.   HYPERTENSION

Atrial natriuretic peptide is negatively regulated by microRNA-425

(2013) Pankaj Arora et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort

(2012) Speranza Rubattu et al.   European Journal of Internal Medicine

Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF)

(2012) Masaaki Miyata et al.   Journal of Cardiology

Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster

(2011) F. Del Greco M. et al.   HUMAN MOLECULAR GENETICS

Molecular mechanisms underlying cardiac antihypertrophic and antifibrotic effects of natriuretic peptides

(2011) Camilla Calvieri et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A Genetic Variant of the Atrial Natriuretic Peptide Gene Is Associated With Cardiometabolic Protection in the General Community

(2011) Valentina Cannone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

(2011) Georg B. Ehret et al.   NATURE

Associations between genetic variations in the FURIN gene and hypertension

(2010) Nanfang Li et al.   BMC Medical Genetics

Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

(2010) Luis Miguel Ruilope et al.   LANCET

Dysfunctional Corin I555(P568) Allele Is Associated With Impaired Brain Natriuretic Peptide Processing and Adverse Outcomes in Blacks With Systolic Heart Failure

(2009) J. Eduardo Rame et al.   Circulation-Heart Failure

Reactive oxygen species-mediated effects on vascular remodeling induced by human atrial natriuretic peptide T2238C molecular variant in endothelial cells in vitro

(2009) Stefania Scarpino et al.   JOURNAL OF HYPERTENSION

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genomewide Association Studies of Stroke

(2009) M. Arfan Ikram et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetic Association of the NPPA T2238C Genetic Variant With Cardiovascular Disease Outcomes in Patients With Hypertension

(2008) Amy I. Lynch et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION