Journal
CELLULAR SIGNALLING
Volume 60, Issue -, Pages 17-30Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cellsig.2019.03.022
Keywords
Membrane receptors; Internalization; Intracellular signaling; Subcellular trafficking; Short-signal motifs; Guanylyl cyclase/Natriuretic peptide receptor
Categories
Funding
- NIH [R01HL057531, R01HL062147]
Ask authors/readers for more resources
Endocytosis is a prominent clathrin-mediated mechanism for concentrated uptake and internalization of ligand-receptor complexes, also known as cargo. Internalization of cargo is the fundamental mechanism for receptor dependent regulation of cell membrane function, intracellular signal transduction, and neurotransmission, as well as other biological and physiological activities. However, the intrinsic mechanisms of receptor endocytosis and contemporaneous intracellular signaling are not well understood. We review emerging concepts of receptor endocytosis with concurrent intracellular signaling, using a typical example of guanylyl cyclase/natriuretic peptide receptor-A (NPRA) internalization, subcellular trafficking, and simultaneous generation of second messenger cGMP and signaling in intact cells. We highlight the role of short-signal motifs located in the carboxyl terminal regions of membrane receptors during their internalization and subsequent receptor trafficking in organelles that are not traditionally studied in this context, including nuclei and mitochondria. This review sheds light on the importance of future investigations of receptor endocytosis and trafficking in live cells and intact animals in vivo in physiological context.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available