Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion

Neuroprotective role of lactate in rat neonatal hypoxia-ischemia

(2020) Hélène Roumes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

(2020) Jean-Noël Hyacinthe et al.   Scientific Reports

Inhibiting glycolysis rescues memory impairment in an intellectual disability Gdi1-null mouse

(2020) Patrizia D'Adamo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication

(2019) Carlos-Alberto Gonçalves et al.   Frontiers in Neuroscience

The lactate receptor HCAR1 modulates neuronal network activity through the activation of Gα and Gβɣ subunits

(2019) Haíssa de Castro Abrantes et al.   JOURNAL OF NEUROSCIENCE

L-Lactate Promotes Adult Hippocampal Neurogenesis

(2019) Yaeli Lev-Vachnish et al.   Frontiers in Neuroscience

Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling

(2019) Claire J. Scavuzzo et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

GPCR desensitization: Acute and prolonged phases

(2018) Sudarshan Rajagopal et al.   CELLULAR SIGNALLING

Hypertonic Lactate to Improve Cerebral Perfusion and Glucose Availability After Acute Brain Injury

(2018) Laurent Carteron et al.   CRITICAL CARE MEDICINE

Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1

(2018) Gabriel Herrera-López et al.   HIPPOCAMPUS

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

Enhancement of Astroglial Aerobic Glycolysis by Extracellular Lactate-Mediated Increase in cAMP

(2018) Nina Vardjan et al.   Frontiers in Molecular Neuroscience

Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection

(2018) P. Jourdain et al.   Scientific Reports

Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis

(2018) Camille Blochet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Cell-specific modulation of monocarboxylate transporter expression contributes to the metabolic reprograming taking place following cerebral ischemia

(2016) K. Rosafio et al.   NEUROSCIENCE

L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade

(2016) P. Jourdain et al.   Scientific Reports

Isoflurane Provides Neuroprotection in Neonatal Hypoxic Ischemic Brain Injury

(2016) Sherrefa R. Burchell et al.   JOURNAL OF INVESTIGATIVE MEDICINE

A Probable Dual Mode of Action for Both L- and D-Lactate Neuroprotection in Cerebral Ischemia

(2015) Ximena Castillo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain

(2014) Pierre Bouzat et al.   INTENSIVE CARE MEDICINE

Comprehensive review on lactate metabolism in human health

(2014) M. Adeva-Andany et al.   MITOCHONDRION

Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1

(2014) Guo Li et al.   PLoS One

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

(2014) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

(2013) K. H. Lauritzen et al.   CEREBRAL CORTEX

Identification and Pharmacokinetics of Novel Alkylresorcinol Metabolites in Human Urine, New Candidate Biomarkers for Whole-Grain Wheat and Rye Intake

(2013) Yingdong Zhu et al.   JOURNAL OF NUTRITION

Neuroprotective effects of lactate in brain ischemia: Dependence on anesthetic drugs

(2013) Tobias Horn et al.   NEUROCHEMISTRY INTERNATIONAL

Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway

(2013) Luigi Bozzo et al.   PLoS One

New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration

(2012) Carole Berthet et al.   CEREBROVASCULAR DISEASES

The Role of Astrocytic Glycogen in Supporting the Energetics of Neuronal Activity

(2012) Mauro DiNuzzo et al.   NEUROCHEMICAL RESEARCH

Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects

(2012) Curt A. Dvorak et al.   ACS Medicinal Chemistry Letters

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

High-resolution spatial mapping of changes in the neurochemical profile after focal ischemia in mice

(2011) Malte F. Alf et al.   NMR IN BIOMEDICINE

Lactate levels in the brain are elevated upon exposure to volatile anesthetics: A microdialysis study

(2010) Tobias Horn et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotective Role of Lactate after Cerebral Ischemia

(2009) Carole Berthet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Evolution of the Neurochemical Profile after Transient Focal Cerebral Ischemia in the Mouse Brain

(2009) Hongxia Lei et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

GPR109A, GPR109B and GPR81, a family of hydroxy-carboxylic acid receptors

(2009) Kashan Ahmed et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Role of GPR81 in lactate-mediated reduction of adipose lipolysis

(2008) Tian-Quan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81

(2008) Changlu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agonist-selective mechanisms of GPCR desensitization

(2007) E Kelly et al.   BRITISH JOURNAL OF PHARMACOLOGY