Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner

Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish

(2021) Philipp M. Tschaikner et al.   DEVELOPMENT

Vertebrate cells differentially interpret ciliary and extraciliary cAMP

(2021) Melissa E. Truong et al.   CELL

Time-resolved proteomics profiling of the ciliary Hedgehog response

(2021) Elena A. May et al.   JOURNAL OF CELL BIOLOGY

Smoothened transduces Hedgehog signals via activity-dependent sequestration of PKA catalytic subunits

(2021) Corvin D. Arveseth et al.   PLOS BIOLOGY

GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

(2020) Rachel K Lex et al.   eLife

Role of cilia in the pathogenesis of congenital heart disease

(2020) George C. Gabriel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling

(2020) Bandarigoda Nipunika Somatilaka et al.   DEVELOPMENTAL CELL

Developmental and regenerative paradigms of cilia regulated hedgehog signaling

(2020) Daniel Kopinke et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium

(2020) Jan N Hansen et al.   eLife

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Optical Mapping of cAMP Signaling at the Nanometer Scale

(2020) Andreas Bock et al.   CELL

Compartmentalized GPCR Signaling from Intracellular Membranes

(2020) Stephanie E. Crilly et al.   JOURNAL OF MEMBRANE BIOLOGY

Cellular signalling by primary cilia in development, organ function and disease

(2019) Zeinab Anvarian et al.   Nature Reviews Nephrology

Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities

(2019) Issei S. Shimada et al.   DEVELOPMENTAL BIOLOGY

Establishing and regulating the composition of cilia for signal transduction

(2019) Maxence V. Nachury et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation

(2019) Jason Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Cilia Signaling Promotes Axonal Tract Development and Is Disrupted in Joubert Syndrome-Related Disorders Models

(2019) Jiami Guo et al.   DEVELOPMENTAL CELL

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

(2018) Fan Ye et al.   JOURNAL OF CELL BIOLOGY

BBS1 is involved in retrograde trafficking of ciliary GPCRs in the context of the BBSome complex

(2018) Shohei Nozaki et al.   PLoS One

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis

(2018) Issei S. Shimada et al.   Cell Reports

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

(2018) Ganesh V. Pusapati et al.   Science Signaling

The regulation of cilium assembly and disassembly in development and disease

(2018) Lei Wang et al.   DEVELOPMENT

Dominant negative GPR161 rare variants are risk factors of human spina bifida

(2018) Sung-Eun Kim et al.   HUMAN MOLECULAR GENETICS

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins

(2017) Hemant B. Badgandi et al.   JOURNAL OF CELL BIOLOGY

Trafficking to the primary cilium membrane

(2017) Saikat Mukhopadhyay et al.   MOLECULAR BIOLOGY OF THE CELL

Shh-mediated centrosomal recruitment of PKA promotes symmetric proliferative neuroepithelial cell division

(2017) Murielle Saade et al.   NATURE CELL BIOLOGY

Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution

(2017) Gary C H Mo et al.   NATURE METHODS

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Discovery, Diagnosis, and Etiology of Craniofacial Ciliopathies

(2017) Elizabeth N. Schock et al.   Cold Spring Harbor Perspectives in Biology

Smoothened determines β-arrestin–mediated removal of the G protein–coupled receptor Gpr161 from the primary cilium

(2016) Kasturi Pal et al.   JOURNAL OF CELL BIOLOGY

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

(2016) Verena A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

(2016) Bryn S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline

(2016) Ching-Fang Chang et al.   PLoS Genetics

The loss of Hh responsiveness by a non-ciliary Gli2 variant

(2015) J. Liu et al.   DEVELOPMENT

The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation

(2015) Bo I. Li et al.   DEVELOPMENTAL BIOLOGY

Proteomics of Primary Cilia by Proximity Labeling

(2015) David U. Mick et al.   DEVELOPMENTAL CELL

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

Endosomal generation of cAMP in GPCR signaling

(2014) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

G-protein-coupled receptors, Hedgehog signaling and primary cilia

(2014) Saikat Mukhopadhyay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Transcriptional regulation of graded Hedgehog signaling

(2014) Kristin N. Falkenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

(2014) Pawel Niewiadomski et al.   Cell Reports

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

 -catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation

(2013) T. Zhao et al.   DEVELOPMENT

The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling

(2013) Ace E. Lewis et al.   DEVELOPMENTAL BIOLOGY

Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants

(2013) Ting Cao et al.   DEVELOPMENTAL BIOLOGY

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ciliary disorder of the skeleton

(2012) Celine Huber et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Mechanistic Differences in the Transcriptional Interpretation of Local and Long-Range Shh Morphogen Signaling

(2012) Tony Oosterveen et al.   DEVELOPMENTAL CELL

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

Craniofacial ciliopathies: A new classification for craniofacial disorders

(2010) Samantha A. Brugmann et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The relationship between sonic Hedgehog signaling, cilia, and neural tube defects

(2010) Jennifer N. Murdoch et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors

(2010) C. Wang et al.   DEVELOPMENT

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

(2010) S. Mukhopadhyay et al.   GENES & DEVELOPMENT

A primary cilia-dependent etiology for midline facial disorders

(2010) Samantha A. Brugmann et al.   HUMAN MOLECULAR GENETICS

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

Kinetics of Hedgehog-Dependent Full-Length Gli3 Accumulation in Primary Cilia and Subsequent Degradation

(2010) X. Wen et al.   MOLECULAR AND CELLULAR BIOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Patterning of ventral telencephalon requires positive function of Gli transcription factors

(2009) Weiying Yu et al.   DEVELOPMENTAL BIOLOGY

Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia

(2009) Jinping Jia et al.   DEVELOPMENTAL BIOLOGY

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling

(2009) Ryan X. Norman et al.   HUMAN MOLECULAR GENETICS

Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base

(2009) M. Barzi et al.   JOURNAL OF CELL SCIENCE

Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

(2009) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent cAMP-Signals Triggered by Internalized G-Protein–Coupled Receptors

(2009) Davide Calebiro et al.   PLOS BIOLOGY

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

(2008) Ahryon Cho et al.   DEVELOPMENTAL BIOLOGY

Unique organization of the frontonasal ectodermal zone in birds and mammals

(2008) Diane Hu et al.   DEVELOPMENTAL BIOLOGY

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation

(2008) Alexander V. Loktev et al.   DEVELOPMENTAL CELL

The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development

(2008) P. G. Matteson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin-Mediated Localization of Smoothened to the Primary Cilium

(2008) J. J. Kovacs et al.   SCIENCE