Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance

(2021) Miyoung Lee et al.   NUCLEIC ACIDS RESEARCH

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

(2020) Åsa Ehlén et al.   Nature Communications

DSS1 and ssDNA regulate oligomerization of BRCA2

(2020) Hang Phuong Le et al.   NUCLEIC ACIDS RESEARCH

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction

(2020) Arshdeep Sidhu et al.   NUCLEIC ACIDS RESEARCH

Particle Mobility Analysis Using Deep Learning and the Moment Scaling Spectrum

(2019) Marloes Arts et al.   Scientific Reports

Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks

(2018) Donna R. Whelan et al.   Nature Communications

Architectural plasticity of human BRCA2–RAD51 complexes in DNA break repair

(2017) Humberto Sánchez et al.   NUCLEIC ACIDS RESEARCH

Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA

(2017) Alex N. Zelensky et al.   Nature Communications

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

(2017) Weiran Feng et al.   Nature Communications

Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2

(2016) Suzanne A. Hartford et al.   PLoS Genetics

SFMetrics: an analysis tool for scanning force microscopy images of biomolecules

(2015) Humberto Sánchez et al.   BMC BIOINFORMATICS

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Functional Ex Vivo Assay to Select Homologous Recombination-Deficient Breast Tumors for PARP Inhibitor Treatment

(2014) K. A. T. Naipal et al.   CLINICAL CANCER RESEARCH

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

(2014) Marcel Reuter et al.   JOURNAL OF CELL BIOLOGY

Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor

(2014) Taha Shahid et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1-PALB2-BRCA2 Complex

(2013) M. Al Abo et al.   CANCER RESEARCH

Near-infrared fluorescent proteins for multicolor in vivo imaging

(2013) Daria M Shcherbakova et al.   NATURE METHODS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Unraveling the mechanism of BRCA2 in homologous recombination

(2011) William K Holloman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

(2011) Nicolas Siaud et al.   PLoS Genetics

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for recruitment of BRCA2 by PALB2

(2009) Antony W Oliver et al.   EMBO REPORTS

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Resistance to therapy caused by intragenic deletion in BRCA2

(2008) Stacey L. Edwards et al.   NATURE