The emerging role of biosynthetic gene clusters in plant defense and plant interactions

Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

(2021) Amit Rai et al.   Nature Communications

Subtelomeric assembly of a multi-gene pathway for antimicrobial defense compounds in cereals

(2021) Yan Li et al.   Nature Communications

A Pathogen-Responsive Gene Cluster for Highly Modified Fatty Acids in Tomato

(2020) Ju Eun Jeon et al.   CELL

Building near-complete plant genomes

(2020) Todd P Michael et al.   CURRENT OPINION IN PLANT BIOLOGY

Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery

(2020) Adam Jozwiak et al.   Nature Chemical Biology

Doing the gene shuffle to close synteny: dynamic assembly of biosynthetic gene clusters

(2020) Reuben J. Peters   NEW PHYTOLOGIST

Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants

(2020) Lingfeng Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant secondary metabolites as defenses, regulators, and primary metabolites: the blurred functional trichotomy

(2020) Matthias Erb et al.   PLANT PHYSIOLOGY

Active and repressed biosynthetic gene clusters have spatially distinct chromosome states

(2020) Hans-Wilhelm Nützmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Plant Secondary Metabolism in Microbial Systems

(2019) Michael E Pyne et al.   PLANT PHYSIOLOGY

Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy

(2019) Mehran Dastmalchi et al.   PLANT PHYSIOLOGY

Drivers of metabolic diversification: how dynamic genomic neighborhoods generate new biosynthetic pathways in the Brassicaceae

(2019) Zhenhua Liu et al.   NEW PHYTOLOGIST

A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat

(2019) Anastasia Orme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis

(2018) Xue Chen et al.   Nature Chemical Biology

Beyond Defense: Multiple Functions of Benzoxazinoids in Maize Metabolism

(2018) Shaoqun Zhou et al.   PLANT AND CELL PHYSIOLOGY

Multigenome analysis implicates miniature inverted-repeat transposable elements (MITEs) in metabolic diversification in eudicots

(2018) Alexander M. Boutanaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Gene Clusters in Eukaryotes

(2018) Hans-Wilhelm Nützmann et al.   Annual Review of Genetics

The opium poppy genome and morphinan production

(2018) Li Guo et al.   SCIENCE

Expansion of sesquiterpene biosynthetic gene clusters in pepper confers nonhost resistance to the Irish potato famine pathogen

(2017) Hyun-Ah Lee et al.   NEW PHYTOLOGIST

The PhytoClust tool for metabolic gene clusters discovery in plant genomes

(2017) Nadine Töpfer et al.   NUCLEIC ACIDS RESEARCH

plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters

(2017) Satria A. Kautsar et al.   NUCLEIC ACIDS RESEARCH

A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants

(2017) Jennifer H. Wisecaver et al.   PLANT CELL

Genome-Wide Prediction of Metabolic Enzymes, Pathways, and Gene Clusters in Plants

(2017) Pascal Schläpfer et al.   PLANT PHYSIOLOGY

Engineered gray mold resistance, antioxidant capacity, and pigmentation in betalain-producing crops and ornamentals

(2017) Guy Polturak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Computational genomic identification and functional reconstitution of plant natural product biosynthetic pathways

(2016) Marnix H. Medema et al.   NATURAL PRODUCT REPORTS

Plant metabolic clusters - from genetics to genomics

(2016) Hans-Wilhelm Nützmann et al.   NEW PHYTOLOGIST

Delineation of metabolic gene clusters in plant genomes by chromatin signatures

(2016) Nan Yu et al.   NUCLEIC ACIDS RESEARCH

A Metabolic Gene Cluster in the WheatW1and the BarleyCer-cquLoci Determines β-Diketone Biosynthesis and Glaucousness

(2016) Shelly Hen-Avivi et al.   PLANT CELL

Biosynthesis of the leucine derived α-, β- and γ-hydroxynitrile glucosides in barley (Hordeum vulgareL.)

(2016) Eva Knoch et al.   PLANT JOURNAL

The biosynthetic gene cluster for the cyanogenic glucoside dhurrin in Sorghum bicolor contains its co-expressed vacuolar MATE transporter

(2016) Behrooz Darbani et al.   Scientific Reports

Engineering of Secondary Metabolism

(2015) Sarah E. O'Connor   Annual Review of Genetics

In Planta Variation of Volatile Biosynthesis: An Alternative Biosynthetic Route to the Formation of the Pathogen-Induced Volatile Homoterpene DMNT via Triterpene Degradation in Arabidopsis Roots

(2015) Reza Sohrabi et al.   PLANT CELL

Genome-guided investigation of plant natural product biosynthesis

(2015) Franziska Kellner et al.   PLANT JOURNAL

Biosynthesis of the Diterpenoid Lycosantalonol via Nerylneryl Diphosphate in Solanum lycopersicum

(2015) Yuki Matsuba et al.   PLoS One

Regulation of metabolic gene clusters inArabidopsis thaliana

(2014) Hans-Wilhelm Nützmann et al.   NEW PHYTOLOGIST

Production of Bioactive Diterpenoids in the Euphorbiaceae Depends on Evolutionarily Conserved Gene Clusters

(2014) A. J. King et al.   PLANT CELL

Investigation of triterpene synthesis and regulation in oats reveals a role for  -amyrin in determining root epidermal cell patterning

(2014) A. C. Kemen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of terpene diversification across multiple sequenced plant genomes

(2014) Alexander M. Boutanaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis, regulation, and domestication of bitterness in cucumber

(2014) Y. Shang et al.   SCIENCE

The rise of operon-like gene clusters in plants

(2014) Svetlana Boycheva et al.   TRENDS IN PLANT SCIENCE

Gene clustering in plant specialized metabolism

(2013) Hans-Wilhelm Nützmann et al.   CURRENT OPINION IN BIOTECHNOLOGY

A metabolic gene cluster inLotus japonicusdiscloses novel enzyme functions and products in triterpene biosynthesis

(2013) Afrodite Krokida et al.   NEW PHYTOLOGIST

Evolution of a Complex Locus for Terpene Biosynthesis in Solanum

(2013) Y. Matsuba et al.   PLANT CELL

Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes

(2013) M. Itkin et al.   SCIENCE

Plant Defense Compounds: Systems Approaches to Metabolic Analysis

(2012) Daniel J. Kliebenstein   Annual Review of Phytopathology

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

Why biosynthetic genes for chemical defense compounds cluster

(2012) Adam M. Takos et al.   TRENDS IN PLANT SCIENCE

KNApSAcK Family Databases: Integrated Metabolite–Plant Species Databases for Multifaceted Plant Research

(2011) Farit Mochamad Afendi et al.   PLANT AND CELL PHYSIOLOGY

Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification inLotus japonicusand suggests the repeated evolution of this chemical defence pathway

(2011) Adam M. Takos et al.   PLANT JOURNAL

Formation of plant metabolic gene clusters within dynamic chromosomal regions

(2011) B. Field et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies for the Discovery of New Natural Products by Genome Mining

(2009) Malek Zerikly et al.   CHEMBIOCHEM

CYP76M7 Is an ent-Cassadiene C11 -Hydroxylase Defining a Second Multifunctional Diterpenoid Biosynthetic Gene Cluster in Rice

(2009) S. Swaminathan et al.   PLANT CELL

Metabolic Diversification--Independent Assembly of Operon-Like Gene Clusters in Different Plants

(2008) B. Field et al.   SCIENCE