Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking

(2020) Jorge Montesinos et al.   EMBO JOURNAL

24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane

(2019) Nobuyoshi Tajima et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

(2019) Jiang Ying et al.   JOURNAL OF NEUROSCIENCE

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesis

(2019) Pilar Esteve et al.   NATURE NEUROSCIENCE

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

The enantiomer pair of 24S‐ and 24R‐hydroxycholesterol differentially alter activity of large‐conductance Ca 2+ ‐dependent K + (slo1 BK) channel

(2019) Xiaoyan Liu et al.   CHIRALITY

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

(2019) Swagata Ghatak et al.   eLife

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

(2018) Benedikt Zott et al.   Annual Review of Neuroscience

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer’s Disease

(2018) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease

(2017) Ralph A. Nixon   FASEB JOURNAL

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

(2017) Lucas J. Sosa et al.   JOURNAL OF NEUROCHEMISTRY

Epileptic activity in Alzheimer's disease: causes and clinical relevance

(2017) Keith A Vossel et al.   LANCET NEUROLOGY

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s disease

(2017) Hassan Bukhari et al.   PROGRESS IN NEUROBIOLOGY

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

APP Protein Family Signaling at the Synapse: Insights from Intracellular APP-Binding Proteins

(2017) Suzanne Guénette et al.   Frontiers in Molecular Neuroscience

Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications

(2016) Marilena Griguoli et al.   JOURNAL OF PHYSIOLOGY-LONDON

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cognitive Improvement by Photic Stimulation in a Mouse Model of Alzheimer’s Disease

(2015) Yu Zhang et al.   Current Alzheimer Research

Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K+ current inhibition mediated by activation of caspases and GSK-3

(2015) Federico Scala et al.   NEUROBIOLOGY OF AGING

Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice

(2015) Furong Wang et al.   NEUROPHARMACOLOGY

Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease

(2015) Li Wang et al.   NEUROPHARMACOLOGY

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

(2014) Hilla Fogel et al.   Cell Reports

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

(2014) M Florencia Iulita et al.   Acta Neuropathologica Communications

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Automated Parallel Recordings of Topologically Identified Single Ion Channels

(2013) Ryuji Kawano et al.   Scientific Reports

Differential Effects between  -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

(2012) Y. Mitani et al.   JOURNAL OF NEUROSCIENCE

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

(2011) Robert Tamayev et al.   EMBO JOURNAL

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Suppression of a Neocortical Potassium Channel Activity by Intracellular Amyloid-  and Its Rescue with Homer1a

(2011) K. Yamamoto et al.   JOURNAL OF NEUROSCIENCE

Increase in Cortical Pyramidal Cell Excitability Accompanies Depression-Like Behavior in Mice: A Transcranial Magnetic Stimulation Study

(2011) P. Sun et al.   JOURNAL OF NEUROSCIENCE

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

(2009) Mariko Kato Hayashi et al.   CELL

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation

(2009) Naoko Inoue et al.   Molecular Brain

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

BK Channel Modulators: A Comprehensive Overview

(2008) Antonio Nardi et al.   CURRENT MEDICINAL CHEMISTRY

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production

(2008) Loukia Parisiadou et al.   NEUROBIOLOGY OF DISEASE