Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells

Single-cell analysis of human B cell maturation predicts how antibody class switching shapes selection dynamics

(2021) Hamish W. King et al.   Science Immunology

Original Antigenic Sin: How Original? How Sinful?

(2020) Jonathan W. Yewdell et al.   Cold Spring Harbor Perspectives in Medicine

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

(2020) Antony B. Holmes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development

(2020) Brian J. Laidlaw et al.   NATURE IMMUNOLOGY

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

(2020) Aurélien Pélissier et al.   Cells

Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

(2020) Rachel Wong et al.   IMMUNITY

The Multifaceted B Cell Response to Influenza Virus

(2019) Jonathan H. Lam et al.   JOURNAL OF IMMUNOLOGY

Large-scale network analysis reveals the sequence space architecture of antibody repertoires

(2019) Enkelejda Miho et al.   Nature Communications

Type I interferon induces CXCL13 to support ectopic germinal center formation

(2019) Alice E. Denton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies

(2019) Ivan Kosik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Class-Switch Recombination Occurs Infrequently in Germinal Centers

(2019) Jonathan A. Roco et al.   IMMUNITY

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Multivalency and Antigenic Threshold in Generating Protective Antibody Responses

(2019) Mark K. Slifka et al.   Frontiers in Immunology

The Maintenance of Memory Plasma Cells

(2019) Laleh Khodadadi et al.   Frontiers in Immunology

IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes

(2019) Madeline J. Price et al.   JOURNAL OF IMMUNOLOGY

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

(2019) Luka Mesin et al.   CELL

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors

(2018) Laleh Haghverdi et al.   NATURE BIOTECHNOLOGY

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

(2018) Karlynn E. Neu et al.   JOURNAL OF CLINICAL INVESTIGATION

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells

(2017) Brian J. Laidlaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

(2017) Nike J. Kräutler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires

(2017) Victor Greiff et al.   JOURNAL OF IMMUNOLOGY

Is It Possible to Develop a “Universal” Influenza Virus Vaccine?

(2017) Davide Angeletti et al.   Cold Spring Harbor Perspectives in Biology

Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development

(2017) Victor Greiff et al.   Cell Reports

CD22 is required for formation of memory B cell precursors within germinal centers

(2017) Craig P. Chappell et al.   PLoS One

Taking the Broad View on B Cell Affinity Maturation

(2016) Karlynn E. Neu et al.   IMMUNITY

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

(2016) Masayuki Kuraoka et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Regulated selection of germinal-center cells into the memory B cell compartment

(2016) Ryo Shinnakasu et al.   NATURE IMMUNOLOGY

Visualizing antibody affinity maturation in germinal centers

(2016) J. M. J. Tas et al.   SCIENCE

destiny: diffusion maps for large-scale single-cell data in R

(2015) Philipp Angerer et al.   BIOINFORMATICS

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.

(2015) Namita T. Gupta et al.   BIOINFORMATICS

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles

(2015) Daniel Gadala-Maria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires

(2015) Victor Greiff et al.   TRENDS IN IMMUNOLOGY

A Simple Flow-Cytometric Method Measuring B Cell Surface Immunoglobulin Avidity Enables Characterization of Affinity Maturation to Influenza A Virus

(2015) Gregory M. Frank et al.   mBio

Divergence of transcriptional landscape occurs early in B cell activation

(2015) Trent Fowler et al.   Epigenetics & Chromatin

Mitochondrial function provides instructive signals for activation-induced B-cell fates

(2015) Kyoung-Jin Jang et al.   Nature Communications

Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

(2015) Meghan O Altman et al.   eLife

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires

(2014) Jason A. Vander Heiden et al.   BIOINFORMATICS

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Clonal selection in the germinal centre by regulated proliferation and hypermutation

(2014) Alexander D. Gitlin et al.   NATURE

How specific is too specific? B-cell responses to viral infections reveal the importance of breadth over depth

(2013) Nicole Baumgarth   IMMUNOLOGICAL REVIEWS

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

(2012) G. D. Victora et al.   BLOOD

Structural and genetic basis for development of broadly neutralizing influenza antibodies

(2012) Daniel Lingwood et al.   NATURE

Pulmonary Infection with Influenza A Virus Induces Site-Specific Germinal Center and T Follicular Helper Cell Responses

(2012) Alexander W. Boyden et al.   PLoS One

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI

(2011) Amaya I. Wolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Plasticity and Heterogeneity in the Generation of Memory B Cells and Long-Lived Plasma Cells: The Influence of Germinal Center Interactions and Dynamics

(2010) K. L. Good-Jacobson et al.   JOURNAL OF IMMUNOLOGY

B-cell fate decisions following influenza virus infection

(2009) Kristina Rothaeusler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia

(2008) H. M. Joo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA