CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

(2020) Jean-Christophe Beltra et al.   IMMUNITY

CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis

(2020) Jinhee Lee et al.   PLoS Pathogens

A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response

(2020) Rujapak Sutiwisesak et al.   PLoS Pathogens

Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion

(2020) Julia Busselaar et al.   Frontiers in Immunology

SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8+ T cells

(2020) Lucie Loyal et al.   Nature Communications

Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

(2019) Sema Kurtulus et al.   IMMUNITY

NR4A transcription factors limit CAR T cell function in solid tumours

(2019) Joyce Chen et al.   NATURE

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

(2019) Kristiyan Kanev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

(2019) Zeyu Chen et al.   IMMUNITY

Statistical determination of synergy based on Bliss definition of drugs independence

(2019) Eugene Demidenko et al.   PLoS One

IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation

(2019) Xun Liu et al.   Frontiers in Immunology

CD4+ T Cell Help Is Required for the Formation of a Cytolytic CD8+ T Cell Subset that Protects against Chronic Infection and Cancer

(2019) Ryan Zander et al.   IMMUNITY

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

(2018) Scott G Hansen et al.   NATURE MEDICINE

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

(2018) Laura M. Snell et al.   IMMUNITY

Transcription Factor IRF4 Promotes CD8 + T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection

(2017) Kevin Man et al.   IMMUNITY

CD4 + T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness

(2017) Tomasz Ahrends et al.   IMMUNITY

Signaling Lymphocytic Activation Molecule Family Member 7 Engagement Restores Defective Effector CD8+ T Cell Function in Systemic Lupus Erythematosus

(2017) Denis Comte et al.   Arthritis & Rheumatology

IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection

(2016) Matthew G. Booty et al.   Scientific Reports

A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

(2016) Stephen M. Carpenter et al.   PLoS Pathogens

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

(2016) Pushpa Jayaraman et al.   PLoS Pathogens

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Tuberculosis and HIV Coinfection: Table 1.

(2015) Judith Bruchfeld et al.   Cold Spring Harbor Perspectives in Medicine

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

Cutting Edge: CD4+ T Cell-Derived IL-2 Is Essential for Help-Dependent Primary CD8+ T Cell Responses

(2014) E. B. Wilson et al.   JOURNAL OF IMMUNOLOGY

Intravascular staining for discrimination of vascular and tissue leukocytes

(2014) Kristin G Anderson et al.   Nature Protocols

Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses

(2012) K. G. Anderson et al.   JOURNAL OF IMMUNOLOGY

CD4+ T Cell-Dependent IFN-  Production by CD8+ Effector T Cells in Mycobacterium tuberculosis Infection

(2012) T. D. Bold et al.   JOURNAL OF IMMUNOLOGY

IFN-  from CD4 T Cells Is Essential for Host Survival and Enhances CD8 T Cell Function during Mycobacterium tuberculosis Infection

(2012) A. M. Green et al.   JOURNAL OF IMMUNOLOGY

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

(2012) J. M. Angelosanto et al.   JOURNAL OF VIROLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo

(2012) J.-s. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Suboptimal Activation of Antigen-Specific CD4+ Effector Cells Enables Persistence of M. tuberculosis In Vivo

(2011) Tyler D. Bold et al.   PLoS Pathogens

Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1

(2010) Xinyuan Zhou et al.   IMMUNITY

Preferential infection and depletion ofMycobacterium tuberculosis–specific CD4 T cells after HIV-1 infection

(2010) Christof Geldmacher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1-Mediated Inhibition

(2010) D. L. Barber et al.   JOURNAL OF IMMUNOLOGY

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

HIV-1 Infection Impairs the Bronchoalveolar T-Cell Response to Mycobacteria

(2009) Barbara Kalsdorf et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distinct Differences in the Expansion and Phenotype of TB10.4 Specific CD8 and CD4 T Cells after Infection with Mycobacterium tuberculosis

(2009) Truc Thi Kim Thanh Hoang et al.   PLoS One

A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection

(2009) J. S. Yi et al.   SCIENCE

IL-21 Is Required to Control Chronic Viral Infection

(2009) H. Elsaesser et al.   SCIENCE

IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection

(2009) A. Frohlich et al.   SCIENCE

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens

Early Depletion ofMycobacterium tuberculosis–Specific T Helper 1 Cell Responses after HIV‐1 Infection

(2008) Christof Geldmacher et al.   JOURNAL OF INFECTIOUS DISEASES