HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

A conserved acidic cluster motif in SERINC5 confers partial resistance to antagonism by HIV-1 Nef

(2020) Charlotte A. Stoneham et al.   JOURNAL OF VIROLOGY

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

(2020) Valerie E. Pye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Super-Resolution Fluorescence Imaging Reveals That Serine Incorporator Protein 5 Inhibits Human Immunodeficiency Virus Fusion by Disrupting Envelope Glycoprotein Clusters

(2020) Yen-Cheng Chen et al.   ACS Nano

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

(2020) Zheng Fan et al.   Science Advances

Structural basis of CD4 downregulation by HIV-1 Nef

(2020) Yonghwa Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SERINC5 Potently Restricts Retrovirus Infection In Vivo

(2020) Uddhav Timilsina et al.   mBio

Capillary zone electrophoresis-tandem mass spectrometry for large-scale phosphoproteomics with the production of over 11000 phosphopeptides from the colon carcinoma HCT116 cell line

(2019) Daoyang Chen et al.   ANALYTICAL CHEMISTRY

The retroviral accessory proteins S2, Nef, and glycoMA use similar mechanisms for antagonizing the host restriction factor SERINC5

(2019) Iqbal Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4 expression and Env conformation are critical for HIV-1 restriction by SERINC5

(2019) Xihe Zhang et al.   JOURNAL OF VIROLOGY

Multifunctional Roles of the N-Terminal Region of HIV-1SF2Nef Are Mediated by Three Independent Protein Interaction Sites

(2019) Swetha Ananth et al.   JOURNAL OF VIROLOGY

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity

(2019) Steven W. Jin et al.   Cell Reports

HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

(2018) Jing Shi et al.   JOURNAL OF VIROLOGY

Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation

(2018) Tingjun Lei et al.   Nature Communications

A Long Cytoplasmic Loop Governs the Sensitivity of the Anti-viral Host Protein SERINC5 to HIV-1 Nef

(2018) Weiwei Dai et al.   Cell Reports

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins

(2017) Chetan Sood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction

(2017) Xianfeng Zhang et al.   JOURNAL OF VIROLOGY

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

Effect of HIV-1 Env on SERINC5 Antagonism

(2016) Saina Beitari et al.   JOURNAL OF VIROLOGY

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

(2016) Tinghu Zhang et al.   Nature Chemical Biology

S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3

(2016) Ajit Chande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins

(2016) Yadvinder S. Ahi et al.   mBio

Structural and Functional Analysis of the Cdk13/Cyclin K Complex

(2016) Ann Katrin Greifenberg et al.   Cell Reports

Third-Generation Electrokinetically Pumped Sheath-Flow Nanospray Interface with Improved Stability and Sensitivity for Automated Capillary Zone Electrophoresis–Mass Spectrometry Analysis of Complex Proteome Digests

(2015) Liangliang Sun et al.   JOURNAL OF PROTEOME RESEARCH

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

The Mitochondrial Translocator Protein, TSPO, Inhibits HIV-1 Envelope Glycoprotein Biosynthesis via the Endoplasmic Reticulum-Associated Protein Degradation Pathway

(2014) T. Zhou et al.   JOURNAL OF VIROLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The structure and substrate specificity of human Cdk12/Cyclin K

(2014) Christian A. Bösken et al.   Nature Communications

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Cyclin K-containing Kinase Complexes Maintain Self-renewal in Murine Embryonic Stem Cells

(2012) Qian Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

(2011) D. Blazek et al.   GENES & DEVELOPMENT

Cyclin K Inhibits HIV-1 Gene Expression and Replication by Interfering with Cyclin-dependent Kinase 9 (CDK9)-Cyclin T1 Interaction in Nef-dependent Manner

(2011) Sohrab Zafar Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

(2010) B. Bartkowiak et al.   GENES & DEVELOPMENT

Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway

(2009) L. L. P. daSilva et al.   JOURNAL OF VIROLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY