Multifunctional Roles of the N-Terminal Region of HIV-1SF2Nef Are Mediated by Three Independent Protein Interaction Sites

Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5

(2019) Yuanfei Wu et al.   mBio

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef

(2018) Amanda J. Chase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

(2018) Jing Shi et al.   JOURNAL OF VIROLOGY

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses

(2018) Ryan P. McNamara et al.   mBio

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles

(2018) J.-H. Lee et al.   EBioMedicine

HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface

(2018) Miguel Lamas-Murua et al.   JOURNAL OF IMMUNOLOGY

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

(2018) Dorota Kmiec et al.   PLoS Pathogens

SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia Virus

(2018) Claudia Firrito et al.   Annual Review of Virology

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles

(2016) Johanna Galaski et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

(2016) Birthe Trautz et al.   JOURNAL OF VIROLOGY

HIV-1 Nef: Taking Control of Protein Trafficking

(2016) Estela A. Pereira et al.   TRAFFIC

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

(2016) Jung-Hyun Lee et al.   EBioMedicine

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

(2016) Christian Ostalecki et al.   EBioMedicine

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

(2015) Nicholas J. Matheson et al.   Cell Host & Microbe

Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors

(2015) Mako Toyoda et al.   JOURNAL OF VIROLOGY

Vpu Is the Main Determinant for Tetraspanin Downregulation in HIV-1-Infected Cells

(2015) Marie Lambelé et al.   JOURNAL OF VIROLOGY

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

(2015) Andrea Imle et al.   mBio

Nef Proteins of Epidemic HIV-1 Group O Strains Antagonize Human Tetherin

(2014) Silvia F. Kluge et al.   Cell Host & Microbe

HIV-1 Nef and Vpu Are Functionally Redundant Broad-Spectrum Modulators of Cell Surface Receptors, Including Tetraspanins

(2014) C. Haller et al.   JOURNAL OF VIROLOGY

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

(2013) Jaclyn K Mann et al.   Retrovirology

HIV-1 Nef Limits Communication between Linker of Activated T Cells and SLP-76 To Reduce Formation of SLP-76-Signaling Microclusters following TCR Stimulation

(2012) L. Abraham et al.   JOURNAL OF IMMUNOLOGY

The Human Immunodeficiency Virus Type 1 Nef and Vpu Proteins Downregulate the Natural Killer Cell-Activating Ligand PVR

(2012) Giulia Matusali et al.   JOURNAL OF VIROLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

(2012) B. Stolp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

(2012) Pieter J Meuwissen et al.   Retrovirology

Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation

(2012) Joya Mukerji et al.   Retrovirology

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin

(2012) Joëlle V. Fritz et al.   VIROLOGY

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

Down-Modulation of CD8   Is a Fundamental Activity of Primate Lentiviral Nef Proteins

(2011) A. Heigele et al.   JOURNAL OF VIROLOGY

Genetic Characterization of HIV Type 1 Nef-Induced Vesicle Secretion

(2010) Syed A. Ali et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation of Cofilin as a General Strategy To Interfere with Actin Remodeling

(2010) B. Stolp et al.   JOURNAL OF VIROLOGY

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

(2009) Claudia Muratori et al.   Cell Host & Microbe

HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin

(2009) Bettina Stolp et al.   Cell Host & Microbe

Inhibition of T-Cell Receptor-Induced Actin Remodeling and Relocalization of Lck Are Evolutionarily Conserved Activities of Lentiviral Nef Proteins

(2009) J. M. Rudolph et al.   JOURNAL OF VIROLOGY

HIV-1 Nef Inhibits Ruffles, Induces Filopodia, and Modulates Migration of Infected Lymphocytes

(2009) C. Nobile et al.   JOURNAL OF VIROLOGY

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

(2009) Stefanie Homann et al.   Retrovirology

Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2

(2009) Bin Jia et al.   PLoS Pathogens

HIV Nef Enhances Tat-Mediated Viral Transcription through a hnRNP-K-Nucleated Signaling Complex

(2008) Dietlinde Wolf et al.   Cell Host & Microbe

A one-step SYBR Green I-based product-enhanced reverse transcriptase assay for the quantitation of retroviruses in cell culture supernatants

(2008) Massimo Pizzato et al.   JOURNAL OF VIROLOGICAL METHODS

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

(2007) Dietlinde Wolf et al.   VIROLOGY

Selective downmodulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses

(2007) Anke Specht et al.   VIROLOGY