Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

The MRE11 complex: A versatile toolkit for the repair of broken DNA

(2020) Giordano Reginato et al.   DNA REPAIR

Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair

(2020) Atsushi Shibata et al.   JOURNAL OF RADIATION RESEARCH

NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation

(2019) Roopesh Anand et al.   EMBO JOURNAL

Shieldin – the protector of DNA ends

(2019) Dheva Setiaputra et al.   EMBO REPORTS

Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling

(2019) Javier Garzón et al.   Cell Reports

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

(2018) Rajat Gupta et al.   CELL

FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells

(2018) Junya Tomida et al.   EMBO JOURNAL

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

(2018) Harveer Dev et al.   NATURE CELL BIOLOGY

SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice

(2018) Steven Findlay et al.   EMBO JOURNAL

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

(2018) Hind Ghezraoui et al.   NATURE

The shieldin complex mediates 53BP1-dependent DNA repair

(2018) Sylvie M. Noordermeer et al.   NATURE

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining

(2017) Songli Zhu et al.   NUCLEIC ACIDS RESEARCH

Inhibition of RIF1 by SCAI Allows BRCA1-Mediated Repair

(2017) Shin-Ya Isobe et al.   Cell Reports

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1)

(2017) Rasa Sukackaite et al.   Scientific Reports

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths

(2016) Shunichi Takeda et al.   JOURNAL OF RADIATION RESEARCH

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

(2016) Kazuhiro Murakami et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination

(2015) Nguyen Ngoc Hoa et al.   PLoS One

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

(2014) S.-i. Hiraga et al.   GENES & DEVELOPMENT

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

(2013) Sébastien Britton et al.   JOURNAL OF CELL BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

(2013) Christopher J Lord et al.   NATURE MEDICINE

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway

(2013) Ryu-Suke Nozawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

53BP1: pro choice in DNA repair

(2013) Michal Zimmermann et al.   TRENDS IN CELL BIOLOGY

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Factors determining DNA double-strand break repair pathway choice in G2 phase

(2011) Atsushi Shibata et al.   EMBO JOURNAL

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Human POGZ modulates dissociation of HP1α from mitotic chromosome arms through Aurora B activation

(2010) Ryu-Suke Nozawa et al.   NATURE CELL BIOLOGY

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

(2008) Simone Difilippantonio et al.   NATURE