Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling

Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes

(2021) Nu Chen et al.   EXPERIMENTAL EYE RESEARCH

Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease

(2020) Zi Ye et al.   Gut Microbes

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

(2020) Pavan Bhargava et al.   JOURNAL OF CLINICAL INVESTIGATION

The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis

(2020) Emma S. Winkler et al.   CELL

Intestinal Microbes in Autoimmune and Inflammatory Disease

(2020) Wan-Jung H. Wu et al.   Frontiers in Immunology

Decreased Expression of TGR5 in Vogt-Koyanagi-Harada (VKH) Disease

(2019) Jinglu Yang et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

Bile acids, microbiota and metabolism

(2018) Sarah A. Taylor et al.   HEPATOLOGY

Dysbiosis in the Gut Bacterial Microbiome of Patients with Uveitis, an Inflammatory Disease of the Eye

(2018) Sama Kalyana Chakravarthy et al.   INDIAN JOURNAL OF MICROBIOLOGY

Mycobacterium tuberculosisPPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2–dependent maturation of dendritic cells

(2018) Haibo Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acids in glucose metabolism in health and disease

(2018) Hagit Shapiro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbiota bile acid metabolism controls cancer immunosurveillance

(2018) Anna Dart   NATURE REVIEWS MICROBIOLOGY

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Development and Evaluation of Diagnostic Criteria for Vogt-Koyanagi-Harada Disease

(2018) Peizeng Yang et al.   JAMA Ophthalmology

Bile Acids Activated Receptors Regulate Innate Immunity

(2018) Stefano Fiorucci et al.   Frontiers in Immunology

Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis

(2018) Yike Huang et al.   Frontiers in Immunology

The gut microbiota drives the impact of bile acids and fat source in diet on mouse metabolism

(2018) Sarah Just et al.   Microbiome

A metagenomic study of the gut microbiome in Behcet’s disease

(2018) Zi Ye et al.   Microbiome

Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes

(2018) Armin Mooranian et al.   Artificial Cells Nanomedicine and Biotechnology

TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells

(2017) Natalia Yanguas-Casás et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

(2017) Michele Biagioli et al.   JOURNAL OF IMMUNOLOGY

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

(2017) Wei Jia et al.   Nature Reviews Gastroenterology & Hepatology

Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine

(2017) Yukiko K. Nakamura et al.   Scientific Reports

Gut microbiota in early pediatric multiple sclerosis: a case−control study

(2016) H. Tremlett et al.   EUROPEAN JOURNAL OF NEUROLOGY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions

(2016) Shahla Abdollahi-Roodsaz et al.   Nature Reviews Rheumatology

Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis

(2016) Peggy P. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Behçet's syndrome patients exhibit specific microbiome signature

(2015) Clarissa Consolandi et al.   AUTOIMMUNITY REVIEWS

Altered Fecal Microbiota in Paediatric Inflammatory Bowel Disease

(2015) Johanna Maukonen et al.   Journal of Crohns & Colitis

Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes

(2015) Sophie Candon et al.   PLoS One

Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis

(2014) Matthew L Stoll et al.   ARTHRITIS RESEARCH & THERAPY

Review on the Worldwide Epidemiology of Uveitis

(2013) Elisabetta Miserocchi et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway

(2012) Riko Ichikawa et al.   IMMUNOLOGY

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

(2011) R. M. Gadaleta et al.   GUT

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

(2009) P. Vavassori et al.   JOURNAL OF IMMUNOLOGY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

Migratory and Lymphoid-Resident Dendritic Cells Cooperate to Efficiently Prime Naive CD4 T cells

(2008) Eric J. Allenspach et al.   IMMUNITY