Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and prevent osteoarthritis of the knee in a mouse model

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

(2020) Wei Liu et al.   Journal of Neuroinflammation

Exosomal transfer of LCP1 promotes osteosarcoma cell tumorigenesis and metastasis by activating the JAK2/STAT3 signaling pathway

(2020) Xuhui Ge et al.   Molecular Therapy-Nucleic Acids

Exosomes derived from miR-155-5p–overexpressing synovial mesenchymal stem cells prevent osteoarthritis via enhancing proliferation and migration, attenuating apoptosis, and modulating extracellular matrix secretion in chondrocytes

(2020) Zhirong Wang et al.   CELL BIOLOGY AND TOXICOLOGY

Network analysis of the relationship between depressive symptoms, demographics, nutrition, quality of life and medical condition factors in the Osteoarthritis Initiative database cohort of elderly North-American adults with or at risk for osteoarthritis

(2019) Marco Solmi et al.   Epidemiology and Psychiatric Sciences

Synovium extra cellular matrices seeded with transduced mesenchymal stem cells stimulate chondrocyte maturation in vitro and cartilage healing in clinically-induced rat-knee lesions in vivo

(2019) Nathalie A. Reisbig et al.   PLoS One

Synthesis of chondroitin sulfate magnesium for osteoarthritis treatment

(2019) Sijing Li et al.   CARBOHYDRATE POLYMERS

Osteoarthritis

(2019) David J Hunter et al.   LANCET

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

(2019) Sho Mokuda et al.   Nature Communications

Stem Cell Senescence: The Obstacle of the Treatment of Degenerative Disk Disease

(2019) Ying Chen et al.   Current Stem Cell Research & Therapy

Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126

(2019) Wei Liu et al.   Acta Biomaterialia

Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine – a new paradigm for tissue repair

(2018) I. M. Bjørge et al.   Biomaterials Science

Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A

(2018) Guping Mao et al.   Stem Cell Research & Therapy

MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis

(2018) Yubao Liu et al.   CELL CYCLE

Developmental Dysplasia of the Hip

(2018) Scott Yang et al.   PEDIATRICS

In vitro and in vivo potentialities for cartilage repair from human advanced knee osteoarthritis synovial fluid-derived mesenchymal stem cells

(2018) Paul Neybecker et al.   Stem Cell Research & Therapy

MSC exosome as a cell-free MSC therapy for cartilage regeneration: Implications for osteoarthritis treatment

(2017) Wei Seong Toh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury

(2015) Dylan Burger et al.   AMERICAN JOURNAL OF PATHOLOGY

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

(2015) Stella Kourembanas   Annual Review of Physiology

LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b

(2015) Dongdong Ti et al.   Journal of Translational Medicine

Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis

(2015) Jieyuan Zhang et al.   Journal of Translational Medicine

Etiology of Femoroacetabular Impingement in Athletes: A Review of Recent Findings

(2015) Amir A. Zadpoor   SPORTS MEDICINE

Lipopolysaccharide preconditioning of adipose-derived stem cells improves liver-regenerating activity of the secretome

(2015) Sang Chul Lee et al.   Stem Cell Research & Therapy

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

(2014) Sonia A. Melo et al.   CANCER CELL

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Mesenchymal stem cells in the treatment of traumatic articular cartilage defects: a comprehensive review

(2014) Troy D Bornes et al.   ARTHRITIS RESEARCH & THERAPY

Exosomes/miRNAs as mediating cell-based therapy of stroke

(2014) Hongqi Xin et al.   Frontiers in Cellular Neuroscience

Enhancing the efficacy of mesenchymal stem cell therapy

(2014) Michalis Mastri   World Journal of Stem Cells

Association of Leg-Length Inequality With Knee Osteoarthritis

(2013) William F. Harvey   ANNALS OF INTERNAL MEDICINE

Argonaute proteins: functional insights and emerging roles

(2013) Gunter Meister   NATURE REVIEWS GENETICS

Pincer deformity does not lead to osteoarthritis of the hip whereas acetabular dysplasia does: acetabular coverage and development of osteoarthritis in a nationwide prospective cohort study (CHECK)

(2013) R. Agricola et al.   OSTEOARTHRITIS AND CARTILAGE

MiR-133b Promotes Neural Plasticity and Functional Recovery After Treatment of Stroke with Multipotent Mesenchymal Stromal Cells in Rats Via Transfer of Exosome-Enriched Extracellular Particles

(2013) Hongqi Xin et al.   STEM CELLS

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Cam impingement causes osteoarthritis of the hip: a nationwide prospective cohort study (CHECK)

(2012) Rintje Agricola et al.   ANNALS OF THE RHEUMATIC DISEASES

Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: Findings from the multicenter osteoarthritis study and the osteoarthritis initiative

(2012) David T. Felson et al.   ARTHRITIS AND RHEUMATISM

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

A Stem Cell-Based Approach to Cartilage Repair

(2012) K. Johnson et al.   SCIENCE

Synovium-Derived Stem Cells: A Tissue-Specific Stem Cell for Cartilage Engineering and Regeneration

(2012) Brendan A. Jones et al.   TISSUE ENGINEERING PART B-REVIEWS

Risk factors in the development of stem cell therapy

(2011) Carla A Herberts et al.   Journal of Translational Medicine

History of knee injuries and knee osteoarthritis: a meta-analysis of observational studies

(2011) S.G. Muthuri et al.   OSTEOARTHRITIS AND CARTILAGE

Human Cord Blood-Derived Endothelial Progenitor Cells and Their Conditioned Media Exhibit Therapeutic Equivalence for Diabetic Wound Healing

(2010) Ji Yeon Kim et al.   CELL TRANSPLANTATION

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Protective effect of lipopolysaccharide preconditioning in hepatic ischaemia reperfusion injury

(2010) Takanori Sano et al.   HPB

Lipopolysaccharides can protect mesenchymal stem cells (MSCs) from oxidative stress-induced apoptosis and enhance proliferation of MSCs via Toll-like receptor(TLR)-4 and PI3K/Akt

(2009) Zhao-jun Wang et al.   CELL BIOLOGY INTERNATIONAL

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

(2009) Ninette Amariglio et al.   PLOS MEDICINE

Human mesenchymal stem cells stimulated by TNF-α, LPS, or hypoxia produce growth factors by an NFκB- but not JNK-dependent mechanism

(2008) Paul R. Crisostomo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

(2008) M B Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism

(2008) T. Ha et al.   CARDIOVASCULAR RESEARCH