Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish

(2020) Emily E. Rosowski   Disease Models & Mechanisms

Itaconic acid inhibits growth of a pathogenic marine Vibrio strain: A metabolomics approach

(2019) Thao Van Nguyen et al.   Scientific Reports

Dimethyl itaconate protects against lippolysacchride-induced mastitis in mice by activating MAPKs and Nrf2 and inhibiting NF-κB signaling pathways

(2019) Caijun Zhao et al.   MICROBIAL PATHOGENESIS

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling

(2019) Wei-Chen Yen et al.   Redox Biology

Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

(2018) Christopher J. Hall et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20

(2018) Emmy Van Quickelberghe et al.   JOURNAL OF PROTEOME RESEARCH

THE ROLE OF METABOLIC REMODELING IN MACROPHAGE POLARIZATION AND ITS EFFECT ON SKELETAL MUSCLE REGENERATION

(2018) Francesca De Santa et al.   ANTIOXIDANTS & REDOX SIGNALING

Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors

(2018) Jonathan M. Weiss et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic and immunological responses of male and female new Zealand Greenshell™ mussels (Perna canaliculus) infected with Vibrio sp.

(2018) Thao V. Nguyen et al.   JOURNAL OF INVERTEBRATE PATHOLOGY

A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system

(2018) Luca Perico et al.   KIDNEY INTERNATIONAL

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

(2018) Monika Bambouskova et al.   NATURE

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

(2018) Jorge Domínguez-Andrés et al.   Cell Metabolism

Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis

(2018) Madhur D. Shastri et al.   Oxidative Medicine and Cellular Longevity

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Salmonella typhimurium Infection Reduces Schistosoma japonicum Worm Burden in Mice

(2017) Xiaoyang Zhu et al.   Scientific Reports

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage

(2016) Beáta Németh et al.   FASEB JOURNAL

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of IRG-1 Reduces Inflammatory Cell Infiltration and Lung Injury in Respiratory Syncytial Virus Infection by Reducing Production of Reactive Oxygen Species

(2016) Ke Ren et al.   JOURNAL OF VIROLOGY

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid

(2016) Jan Naujoks et al.   PLoS Pathogens

Control of Insulin Secretion by Production of Reactive Oxygen Species: Study Performed in Pancreatic Islets from Fed and 48-Hour Fasted Wistar Rats

(2016) Ana Cláudia Munhoz et al.   PLoS One

IRG1 induced by heme oxygenase-1/carbon monoxide inhibits LPS-mediated sepsis and pro-inflammatory cytokine production

(2015) Md Jamal Uddin et al.   Cellular & Molecular Immunology

Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells

(2015) Jie Lu et al.   NEUROTOXICOLOGY AND TERATOLOGY

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

(2014) Anna Stincone et al.   BIOLOGICAL REVIEWS

Systemic Responses of BALB/c Mice to Salmonella typhimurium Infection

(2014) Xiaoyang Zhu et al.   JOURNAL OF PROTEOME RESEARCH

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

(2014) Chinnaswamy Tiruppathi et al.   NATURE IMMUNOLOGY

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

(2013) Christopher J. Hall et al.   Cell Metabolism

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Exposure to low- vs iso-osmolar contrast agents reduces NADPH-dependent reactive oxygen species generation in a cellular model of renal injury

(2013) Giuseppe Stefano Netti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species

(2013) Yingke Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1H NMR-based Metabolomic Profiling in Mice Infected withMycobacterium tuberculosis

(2011) Ji-Hyun Shin et al.   JOURNAL OF PROTEOME RESEARCH

Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation

(2011) Cheryl L. Strelko et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology