Cyclooxygenase (COX)-2 modulates Toxoplasma gondii infection, immune response and lipid droplets formation in human trophoblast cells and villous explants

Biogenic Silver Nanoparticles Can Control Toxoplasma gondii Infection in Both Human Trophoblast Cells and Villous Explants

(2021) Idessania Nazareth Costa et al.   Frontiers in Microbiology

Copaifera spp. oleoresins impair Toxoplasma gondii infection in both human trophoblastic cells and human placental explants

(2020) Samuel Cota Teixeira et al.   Scientific Reports

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

(2020) Suelen Silva Gomes Dias et al.   PLoS Pathogens

Cyclooxygenase (COX)-2 Inhibitors Reduce Toxoplasma gondii Infection and Upregulate the Pro-inflammatory Immune Response in Calomys callosus Rodents and Human Monocyte Cell Line

(2019) Ana Carolina Alcântara Pereira et al.   Frontiers in Microbiology

Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2

(2019) Iliana Claudia Balga Milian et al.   Frontiers in Microbiology

Lipid Droplets: A Significant but Understudied Contributor of Host–Bacterial Interactions

(2019) Cassandra L. Libbing et al.   Cells

Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

(2019) R.M. Botelho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Parasite-Produced MIF Cytokine: Role in Immune Evasion, Invasion, and Pathogenesis

(2019) Swagata Ghosh et al.   Frontiers in Immunology

Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids

(2018) Lena Pernas et al.   Cell Metabolism

Annexin A1 peptide is able to induce an anti-parasitic effect in human placental explants infected by Toxoplasma gondii

(2018) Marystela Fávero de Oliveira Cardoso et al.   MICROBIAL PATHOGENESIS

Lipid Droplets as Immune Modulators in Myeloid Cells

(2018) Martijn H. den Brok et al.   TRENDS IN IMMUNOLOGY

Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism

(2018) Patrícia E. de Almeida et al.   Frontiers in Microbiology

Macrophage Migration Inhibitory Factor (MIF) Prevents Maternal Death, but Contributes to Poor Fetal Outcome During Congenital Toxoplasmosis

(2018) Angelica O. Gomes et al.   Frontiers in Microbiology

Extracellular Vesicles Shed By Trypanosoma cruzi Potentiate Infection and Elicit Lipid Body Formation and PGE2 Production in Murine Macrophages

(2018) Maria Isabel Lovo-Martins et al.   Frontiers in Immunology

Lipid Droplet, a Key Player in Host-Parasite Interactions

(2018) Adriana Lima Vallochi et al.   Frontiers in Immunology

Azithromycin treatment is able to control the infection by two genotypes of Toxoplasma gondii in human trophoblast BeWo cells

(2017) Mayara Ribeiro et al.   EXPERIMENTAL PARASITOLOGY

Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-γ in cerebral malaria-susceptible and resistant mice

(2017) Tatiana K.S. Borges et al.   IMMUNOBIOLOGY

The coccidian parasites Toxoplasma and Neospora dysregulate mammalian lipid droplet biogenesis

(2017) Xiaoyu Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myenteric neuroprotective role of aspirin in acute and chronic experimental infections with Trypanosoma cruzi

(2017) J. Y. Oda et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

(2017) Sabrina J. Nolan et al.   PLoS Pathogens

Enrofloxacin and Toltrazuril Are Able to Reduce Toxoplasma gondii Growth in Human BeWo Trophoblastic Cells and Villous Explants from Human Third Trimester Pregnancy

(2017) Rafaela J. da Silva et al.   Frontiers in Cellular and Infection Microbiology

Response to Trypanosoma cruzi by Human Blood Cells Enriched with Dentritic Cells Is Controlled by Cyclooxygenase-2 Pathway

(2017) Sandra C. H. Lonien et al.   Frontiers in Microbiology

Lipid droplet hijacking by intracellular pathogens

(2016) Philippe Roingeard et al.   CELLULAR MICROBIOLOGY

Lipid droplets in leukocytes: Organelles linked to inflammatory responses

(2016) Rossana C.N. Melo et al.   EXPERIMENTAL CELL RESEARCH

Vertical transmission and fetal damage in animal models of congenital toxoplasmosis: A systematic review

(2016) José Antonio Vargas-Villavicencio et al.   VETERINARY PARASITOLOGY

Lipid Body Organelles within the Parasite Trypanosoma cruzi: A Role for Intracellular Arachidonic Acid Metabolism

(2016) Daniel A. M. Toledo et al.   PLoS One

IL10, TGF Beta1, and IFN Gamma Modulate Intracellular Signaling Pathways and Cytokine Production to Control Toxoplasma gondii Infection in BeWo Trophoblast Cells1

(2015) Bellisa Freitas Barbosa et al.   BIOLOGY OF REPRODUCTION

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

(2015) Judit Svensson-Arvelund et al.   JOURNAL OF IMMUNOLOGY

Trophoblast-macrophage crosstalk on human extravillous under Toxoplasma gondii infection

(2015) P.M. Guirelli et al.   PLACENTA

The PGE2/IL-10 Axis Determines Susceptibility of B-1 Cell-Derived Phagocytes (B-1CDP) to Leishmania major Infection

(2015) Angélica F. Arcanjo et al.   PLoS One

Understanding the Complexity of the Immune System during Pregnancy

(2014) Karen Racicot et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inhibition of Cyclooxygenase-1 and Cyclooxygenase-2 Impairs Trypanosoma cruzi Entry into Cardiac Cells and Promotes Differential Modulation of the Inflammatory Response

(2014) Aparecida D. Malvezi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phospholipase A2 regulation of lipid droplet formation

(2014) Carlos Guijas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Association of Hepatitis C Virus Glycoproteins with Apolipoproteins E and B Early in Assembly Is Conserved in Lipoviral Particles

(2014) Audrey Boyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Azithromycin is able to control Toxoplasma gondii infection in human villous explants

(2014) Letícia S Castro-Filice et al.   Journal of Translational Medicine

Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

(2014) Laura Azeredo Miranda Mota et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Toxoplasma gondii-skeletal muscle cells interaction increases lipid droplet biogenesis and positively modulates the production of IL-12, IFN-g and PGE2

(2014) Alessandra F Gomes et al.   Parasites & Vectors

Susceptibility to Toxoplasma gondii proliferation in BeWo human trophoblast cells is dose-dependent of macrophage migration inhibitory factor (MIF), via ERK1/2 phosphorylation and prostaglandin E2 production

(2014) B.F. Barbosa et al.   PLACENTA

Immunology of the Maternal-Fetal Interface

(2013) Adrian Erlebacher   Annual Review of Immunology

Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways

(2013) P. Goyal et al.   MOLECULAR HUMAN REPRODUCTION

Epidemiological review of toxoplasmosis in humans and animals in Romania

(2013) J. P. DUBEY et al.   PARASITOLOGY

Trophoblast cells are able to regulate monocyte activity to control Toxoplasma gondii infection

(2013) A.S. Castro et al.   PLACENTA

Reprogramming Neutral Lipid Metabolism in Mouse Dendritic Leucocytes Hosting Live Leishmania amazonensis Amastigotes

(2013) Hervé Lecoeur et al.   PLoS Neglected Tropical Diseases

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

Application of Human Placental Villous Tissue Explants to Study ABC Transporter Mediated Efflux of 2,4-Dinitrophenyl-S-Glutathione

(2012) Soniya S. Vaidya et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Interleukin-6 in pregnancy and gestational disorders

(2012) Jelmer R. Prins et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cytokines and chemokines production by mononuclear cells from parturient women after stimulation with live Toxoplasma gondii

(2012) K. Rezende-Oliveira et al.   PLACENTA

Effect of Macrophage Migration Inhibitory Factor (MIF) in Human Placental Explants Infected with Toxoplasma gondii Depends on Gestational Age

(2011) Angelica de Oliveira Gomes et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

TLR6-Driven Lipid Droplets in Mycobacterium leprae-Infected Schwann Cells: Immunoinflammatory Platforms Associated with Bacterial Persistence

(2011) K. A. Mattos et al.   JOURNAL OF IMMUNOLOGY

Host Cell Lipid Bodies Triggered by Trypanosoma cruzi Infection and Enhanced by the Uptake of Apoptotic Cells Are Associated With Prostaglandin E2 Generation and Increased Parasite Growth

(2011) Heloisa D’Avila et al.   JOURNAL OF INFECTIOUS DISEASES

Azithromycin and spiramycin induce anti-inflammatory response in human trophoblastic (BeWo) cells infected by Toxoplasma gondii but are able to control infection

(2011) P.S. Franco et al.   PLACENTA

Lipid body function in eicosanoid synthesis: An update

(2011) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Toxoplasma gondii effectors are master regulators of the inflammatory response

(2011) Mariane B. Melo et al.   TRENDS IN PARASITOLOGY

BeWo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferon-γ, interleukin-10 and transforming growth factor-β1

(2010) B. F. Barbosa et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toxoplasma gondii: Impaired maturation and pro-inflammatory response of dendritic cells in MIF-deficient mice favors susceptibility to infection

(2010) Cesar A. Terrazas et al.   EXPERIMENTAL PARASITOLOGY

Lipid droplets: A dynamic organelle moves into focus

(2010) Mathias Beller et al.   FEBS LETTERS

Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication

(2010) W. Cheung et al.   JOURNAL OF VIROLOGY

Cytosolic phospholipase A2-driven PGE2 synthesis within unsaturated fatty acids-induced lipid bodies of epithelial cells☆

(2009) Luciana S. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Leukocyte lipid bodies — Biogenesis and functions in inflammation

(2009) Patricia T. Bozza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells

(2008) M. T. Accioly et al.   CANCER RESEARCH

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Clinical Practice: Management ofToxoplasma gondiiInfection during Pregnancy

(2008) Jose G. Montoya et al.   CLINICAL INFECTIOUS DISEASES

The immunobiology of the innate response to Toxoplasma gondii

(2008) Catherine M. Miller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole

(2008) J. L. Cocchiaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Migration Inhibitory Factor Is Up-Regulated in Human First-Trimester Placenta Stimulated by Soluble Antigen of Toxoplasma gondii, Resulting in Increased Monocyte Adhesion on Villous Explants

(2007) Eloisa Amália Vieira Ferro et al.   AMERICAN JOURNAL OF PATHOLOGY

Trypanosoma cruzi: The role of PGE2 in immune response during the acute phase of experimental infection

(2007) G.K. Abdalla et al.   EXPERIMENTAL PARASITOLOGY