Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway

Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis

(2020) Jinhang Gao et al.   JOURNAL OF HEPATOLOGY

Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing

(2020) Shuhei Suzuki et al.   Biomedicines

The systemic inflammation hypothesis: Towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

(2020) Vicente Arroyo et al.   JOURNAL OF HEPATOLOGY

Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway

(2019) Li-Hua Cui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

SVIP alleviates CCl4-induced liver fibrosis via activating autophagy and protecting hepatocytes

(2019) Dan Jia et al.   Cell Death & Disease

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats

(2019) Hala Salah Abdel-Kawy   DRUG AND CHEMICAL TOXICOLOGY

Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis

(2019) Liping Ling et al.   Molecular Medicine Reports

IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway

(2019) Ting-Juan Huang et al.   BIOMEDICINE & PHARMACOTHERAPY

LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

(2019) Meng Xu et al.   CELL

Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice

(2019) Ying Wu et al.   Drug Design Development and Therapy

RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells

(2019) Zili Zhang et al.   Autophagy

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

(2019) Haojie Wang et al.   Cells

PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis

(2018) Pallavi Varshney et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2

(2018) Enis Kostallari et al.   HEPATOLOGY

Gα 12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

(2018) Kyu Min Kim et al.   JOURNAL OF HEPATOLOGY

Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells

(2018) Dongxiao Meng et al.   BIOMEDICINE & PHARMACOTHERAPY

Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways

(2018) Lina Ba et al.   PHYTOMEDICINE

Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis

(2018) Sandra Alejandra Serna-Salas et al.   Biomed Research International

Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice

(2017) Jiaxian Guo et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings

(2017) Dayun Feng et al.   JOURNAL OF PINEAL RESEARCH

Adenoviral-bone morphogenetic protein-7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model

(2017) Daniel Cervantes-Garcia et al.   Molecular Medicine Reports

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

Doxazosin Treatment Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor β Secretion

(2016) Martin Humberto Muñoz-Ortega et al.   Gut and Liver

Relative cytotoxic potencies and cell death mechanisms of α1-adrenoceptor antagonists in prostate cancer cell lines

(2016) Amanda Forbes et al.   PROSTATE

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy

(2015) Raj Kishore et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reversibility of liver fibrosis

(2015) Mengxi Sun et al.   Clinics and Research in Hepatology and Gastroenterology

Autophagy: A Multifaceted Partner in Liver Fibrosis

(2014) Ariane Mallat et al.   Biomed Research International

Autophagy: A new player in hepatic stellate cell activation

(2012) Lien F.R. Thoen et al.   Autophagy

Structural and Mechanical Differences between Collagen Homo- and Heterotrimers: Relevance for the Molecular Origin of Brittle Bone Disease

(2012) Shu-Wei Chang et al.   BIOPHYSICAL JOURNAL

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

A role for autophagy during hepatic stellate cell activation

(2011) Lien F.R. Thoen et al.   JOURNAL OF HEPATOLOGY

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Time to re-appraise the role of alpha-1 adrenoceptor antagonists in the management of hypertension?

(2010) Neil Chapman et al.   JOURNAL OF HYPERTENSION

The α1-adrenergic receptor antagonist doxazosin inhibits EGFR and NF-κB signalling to induce breast cancer cell apoptosis

(2007) Hongxiang Hui et al.   EUROPEAN JOURNAL OF CANCER