A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica

Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway

(2021) Xianbang Hou et al.   Journal of Natural Medicines

Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action

(2020) Li-xing Nie et al.   JOURNAL OF ETHNOPHARMACOLOGY

In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam

(2020) Nhan Trong Le et al.   Plants-Basel

Lignans from linseed (Linum usitatissimum L.) and its allied species: Retrospect, introspect and prospect

(2020) Himanshu Chhillar et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Antiviral activity of a polysaccharide from Radix Isatidis (Isatis indigotica Fortune) against hepatitis B virus (HBV) in vitro via activation of JAK/STAT signal pathway

(2020) Tianbao Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle

(2020) Nhan Trong Le et al.   Antibiotics-Basel

Secoisolariciresinol diglucoside protects against cadmium-induced oxidative stress-mediated renal toxicity in rats

(2020) Tareq Aqeel et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV)

(2020) Giuseppina Sanna et al.   NATURAL PRODUCT RESEARCH

Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam

(2020) Nhan Trong Le et al.   Journal of Infection in Developing Countries

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

(2020) Keli Chen et al.   Viruses-Basel

Isaindigotone as an inhibitor of the lipopolysaccharide‑induced inflammatory reaction of BV‑2 cells and corresponding mechanisms

(2019) Hui Xiao et al.   Molecular Medicine Reports

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

The anti-diabetic activities, gut microbiota composition, the anti-inflammatory effects of Scutellaria–coptis herb couple against insulin resistance-model of diabetes involving the toll-like receptor 4 signaling pathway

(2019) Chang-hua Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Different types of effective fractions from Radix Isatidis revealed a multiple-target synergy effect against respiratory syncytial virus through RIG-I and MDA5 signaling pathways, a pilot study to testify the theory of superposition of traditional Chinese Medicine efficacy

(2019) Huiqin Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

A comprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens

(2019) Saika Tariq et al.   MICROBIAL PATHOGENESIS

Protective Effects of Aqueous Extract of Radix Isatidis on Lipopolysaccharide-Induced Sepsis in C57BL/6J Mice

(2019) Deqing Ruan et al.   JOURNAL OF MEDICINAL FOOD

Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway

(2019) Naihua Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis

(2018) Kandhasamy Sowndhararajan et al.   BIOMEDICINE & PHARMACOTHERAPY

Separation and Quantification of Four Main Chiral Glucosinolates in Radix Isatidis and Its Granules Using High-Performance Liquid Chromatography/Diode Array Detector Coupled with Circular Dichroism Detection

(2018) Yanhong Shi et al.   MOLECULES

Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway

(2018) Xiang Cui et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models

(2017) Hae Nim Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Radix isatidis Polysaccharides Inhibit Influenza a Virus and Influenza A Virus-Induced Inflammation via Suppression of Host TLR3 Signaling In Vitro

(2017) Zhengtu Li et al.   MOLECULES

The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages

(2017) Ralph A. Pietrofesa et al.   Oxidative Medicine and Cellular Longevity

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

A review on the pharmacological effects of vitexin and isovitexin

(2016) Miao He et al.   FITOTERAPIA

Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways

(2016) Hongming Lv et al.   International Journal of Biological Sciences

Molecular mechanisms of innate memory and tolerance to LPS

(2016) John J. Seeley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

(2015) Jin-Hyung Lee et al.   TRENDS IN MICROBIOLOGY

n-Butanol extract from Folium isatidis inhibits lipopolysaccharide-induced inflammatory cytokine production in macrophages and protects mice against lipopolysaccharide-induced endotoxic shock

(2015) Lili Dong et al.   Drug Design Development and Therapy

In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion

(2014) Ping Xiao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparison of reversed-phase liquid chromatography and hydrophilic interaction chromatography for the fingerprint analysis ofRadix isatidis

(2014) Cong-En Zhang et al.   JOURNAL OF SEPARATION SCIENCE

Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis

(2014) Li-Wei He et al.   MOLECULES

Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

(2013) Annina M. Hafner et al.   ADVANCED DRUG DELIVERY REVIEWS

Research Progress of Chinese Herbal Medicine Radix isatidis (Banlangen)

(2013) Wei Zhou et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Antiviral Activity of Folium Isatidis Derived Extracts In Vitro and In Vivo

(2013) You-Ping Deng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Cytosolic Sensing of Viruses

(2013) Delphine Goubau et al.   IMMUNITY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell

(2011) Xiaoli Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Antimicrobial Peptides Inhibit Polyinosinic-Polycytidylic Acid-Induced Immune Responses

(2011) M. Hasan et al.   JOURNAL OF IMMUNOLOGY

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

A review of the pharmacological effects of Arctium lappa (burdock)

(2010) Yuk-Shing Chan et al.   INFLAMMOPHARMACOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

The Anti-Inflammatory Effects of a Methanolic Extract from Radix Isatidis in Murine Macrophages and Mice

(2009) Eun Kyung Shin et al.   INFLAMMATION

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Effect of Radix Isatidis polysaccharides on immunological function and expression of immune related cytokines in mice

(2008) Yan-ling Zhao et al.   Chinese Journal of Integrative Medicine