Review
Plant Sciences
Jiao Chen, Zongping Zhu, Tianhui Gao, Yi Chen, Qingsong Yang, Chaomei Fu, Yaning Zhu, Fang Wang, Wan Liao
Summary: Isatidis Radix (Banlangen) and Isatidis Folium (Daqingye) have been commonly used as traditional edible-medicinal herbs for detoxifying and treating influenza and viral infectious diseases. Recent studies have confirmed their effectiveness in antiviral, antibacterial, and immune diseases, with differences in their pharmacological properties. Further comprehensive studies are needed for their utilization.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Faqin Wang, Jingting Bi, Liwei He, Jing Chen, Qiangzi Zhang, Xianbang Hou, Huiqin Xu
Summary: Three new natural alkaloids isolated from Radix Isatidis were identified through nuclear magnetic resonance, while liquid chromatography tandem mass spectrometry analysis detected 33 compounds in the plasma of treated rats, with 24 of them being indole alkaloids, including newly identified compounds. Molecular docking and in vitro antithrombin activity tests showed HA inhibition activity of indoleacetonitriles.
Article
Chemistry, Medicinal
Lutong Ren, Qiang Li, Hui Li, Xiaoyan Zhan, Ruichuang Yang, Zhiyong Li, Zhie Fang, Tingting Liu, Ziying Wei, Jia Zhao, Li Lin, Wenqing Mou, Wenzhang Dai, Zhaofang Bai, Guang Xu, Junling Cao
Summary: The polysaccharide extract from Isatidis Radix has potent antiinflammatory and antiviral activities by blocking the activation of NLRP3 inflammasome and reducing the secretion of pro-inflammatory cytokines. In a mouse model of gout, oral administration of the extract can alleviate ankle swelling and cytokine release, and modulate T cell immune activity.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yo-Han Han, Ji-Ye Kee
Summary: This study confirmed the anti-adipogenic effect of Isatidis Radix (IR) by inhibiting lipid accumulation in cells and a high-fat diet-induced obese mouse model. IR suppressed reactive oxygen species production, inhibited the expression of key genes involved in lipid synthesis and oxidation, and reduced weight gain and fat accumulation. Furthermore, IR extract decreased serum levels of free fatty acids, total cholesterol, and LDL cholesterol, suggesting its potential as an anti-obesity drug.
Article
Biochemistry & Molecular Biology
Mastaneh Safarnejad Shad, Sandra Claes, Eline Goffin, Tom Van Loy, Dominique Schols, Steven De Jonghe, Wim Dehaen
Summary: The expansion of the structure-activity relationship study of CXCR4 antagonists led to the synthesis of a series of isoquinolines with excellent activity, among which compound 24c showed consistently low nanomolar activity in various assays and was deemed the most promising.
Article
Biotechnology & Applied Microbiology
Zixuan Zhang, Mingpu Tan, Yingying Zhang, Yue Jia, Shuxian Zhu, Jiang Wang, Jiajing Zhao, Yueyue Liao, Zengxu Xiang
Summary: This study revealed that polyploidization contributed to the increased content of active compounds in autotetraploid roots and modulated lignan biosynthesis. The integrative analysis showed a close correlation between polyploidy-responsive metabolites and differentially expressed genes, highlighting key functional genes and regulators in the gene-lignan pathway network.
Article
Medicine, Research & Experimental
Wei Tao, Ting Fu, Zhuo-Jing He, Han-Peng Zhou, Yan Hong
Summary: Radix isatidis polysaccharides exhibit good immunomodulatory effects, enhancing macrophage activity and promoting the release of inflammatory mediators. It may be associated with Toll-like receptor-4 and showed improved immune function in mouse experiments when stimulated by inactivated herpes simplex virus type 2.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Pukar Khanal, Yadu Nandan Dey, Rajesh Patil, Rupesh Chikhale, Manish M. Wanjari, Shailendra S. Gurav, B. M. Patil, Bhavana Srivastava, Sudesh N. Gaidhani
Summary: The study reveals a strong interaction between andrographolide and its derivative 14-deoxy-11,12-didehydroandrographolide with COVID-19 associated target proteins, showing different immunoregulatory pathways.
Article
Chemistry, Physical
Zhao Li, Xi Zhang, Yiyue Feng, Yingmei Lu, Yuehua Li, Weifan Jiang, Yuqing Wang, Liming Xie, Zhen Wang
Summary: This study designed and synthesized a series of 1-styryl isoquinoline derivatives, and demonstrated that compounds 14 and 20 had significant anti-proliferation activities against gastric cancer cells, with low toxicity on normal cells. Mechanism studies suggested that compounds 14 and 20 induced cell apoptosis through inhibiting the PI3K/Akt/mTOR signaling pathway and activating the mitochondrial apoptotic pathway. Additionally, compounds 14 and 20 showed anti-migration and anti-invasion potential.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Medicine, General & Internal
Bin Yu, Fei Lin, Hong Ning, Baodong Ling
Summary: The study analyzed Banlangen and COVID-19 through network pharmacology technology, revealing that the active ingredients in Banlangen may participate in various biological processes and have potential pharmacological effects on COVID-19.
Article
Chemistry, Medicinal
Yuqing Wang, Lin Long, Linsheng Zhuo, Honghua Zhang, Tian Luo, Jiedan Deng, Yuying Wang, Zhao Li, Zhen Wang, Xue Peng
Summary: In this study, 18 derivatives of 1-styrene-isoquinoline were synthesized from resveratrol and iso-quinoline. Compound 1c exhibited significant anti-tumor activity against Huh7 and SK-Hep-1 cells. It could inhibit cell proliferation, induce apoptosis, and inhibit cell migration and invasion through regulating EMT. Compound 1c also showed potential in inhibiting tumor growth in vivo and could regulate mitochondrial apoptosis pathway and PI3K/Akt/mTOR signaling pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Integrative & Complementary Medicine
Zhenyu Fan, Liangliang Cai, Yage Wang, Qiuyan Zhu, Shengnan Wang, Bohua Chen
Summary: Isatidis Radix, a traditional herb, exhibits anti-inflammatory properties by regulating the phosphorylation of MAPK pathway and NF-κB pathway, ultimately reducing the expression of inflammation-related genes. This mechanism may explain its potential therapeutic effects on conditions like cold, fever, and sore throat.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Xuelian Xiang, Jiadai Lv, Mengyi Dong, Nianling Li, Yongxin Li, Andong Wang, Yuxi Shen, Shuyun Li, Jing Xu, Min Cui, Xinfeng Han, Jing Xia, Yong Huang
Summary: This study aimed to explore the effects and mechanisms of Radix Isatidis polysaccharide (RIP) on kidney damage caused by infectious bronchitis virus (IBV) in poultry. The results showed that RIP could alleviate virus-induced kidney damage, reduce cell susceptibility to virus infection, and decrease viral loads. RIP also regulated the expression of inflammatory factors and immune pathway genes, enhancing resistance to IBV infection.
Article
Biotechnology & Applied Microbiology
Vengala Rao Yenuganti, Sumbul Afroz, Rafiq Ahmad Khan, Chandrima Bharadwaj, Deepti Kailash Nabariya, Nagaraj Nayak, Madhuri Subbiah, Kumaraswami Chintala, Sharmistha Banerjee, Pallu Reddanna, Nooruddin Khan
Summary: This study demonstrates the antiviral properties of milk exosomes and opens new avenues for the development of exosome-based therapies to treat viral diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Huiting Wang, Xiaoman Zheng, Yongshi Lin, Xirui Zheng, Mingen Yan, Yaoxing Li, Dayou Shi, Shining Guo, Cui Liu
Summary: The study found that the mixture of Radix isatidis, Forsythiae, and Gypsum (RIFG) has a good antipyretic effect on LPS-induced fever in broilers. RIFG can lower body temperature, inhibit the expression of inflammatory genes and proteins, and promote the generation of antipyretic factors.
