Tetramethylpyrazine Improves Cognitive Function of Alzheimer’s Disease Mice by Regulating SSTR4 Ubiquitination

Tetramethylpyrazine exerts a protective effect against injury from acute myocardial ischemia by regulating the PI3K/Akt/GSK-3β signaling pathway

(2019) Qing Yang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Angiotensin II triggers autophagy and apoptosis in PC12 cell line: An in vitro Alzheimer’s disease model

(2019) Minjie Tian et al.   BRAIN RESEARCH

Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo

(2019) Hefeng Zhou et al.   Oxidative Medicine and Cellular Longevity

Synthesis and biological evaluation of new tetramethylpyrazine based chalcone derivatives as potential anti-Alzheimer agents

(2018) Meng Wang et al.   Chemical Biology & Drug Design

PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β

(2017) Linjie Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Higher susceptibility of somatostatin 4 receptor gene-deleted mice to chronic stress-induced behavioral and neuroendocrine alterations

(2017) Bálint Scheich et al.   NEUROSCIENCE

Alzheimer’s disease prevention: from risk factors to early intervention

(2017) Marta Crous-Bou et al.   Alzheimers Research & Therapy

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBNand Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

(2016) Dolores Del Prete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective

(2016) Yingke Zhao et al.   Oxidative Medicine and Cellular Longevity

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain

(2015) Pritika J. Narayan et al.   NEUROBIOLOGY OF DISEASE

Effects of pyrrolidine dithiocarbamate on proliferation and nuclear factor-κB activity in autosomal dominant polycystic kidney disease cells

(2015) Michelle H. T. Ta et al.   BMC Nephrology

History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer's Disease

(2014) Ping Liu et al.   Evidence-based Complementary and Alternative Medicine

Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-κB Signaling Activation in Insulinoma

(2014) Qian-Qian Zhang et al.   International Journal of Biological Sciences

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia

(2014) Meijuan Zhang et al.   NEUROBIOLOGY OF DISEASE

Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients

(2014) Christian Grosser et al.   NEUROSCIENCE LETTERS

Inhibition of Angiogenesis, Fibrosis and Thrombosis by Tetramethylpyrazine: Mechanisms Contributing to the SDF-1/CXCR4 Axis

(2014) Xiaoxiao Cai et al.   PLoS One

Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons

(2014) Gu Gong et al.   PLoS One

Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells

(2014) XiaoLei Zheng et al.   PLoS One

High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AβPP Processing and Cognition in Female APP/PS1 Mice

(2014) Yunhua Peng et al.   Frontiers in Cellular Neuroscience

Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway

(2013) Wei Wu et al.   BEHAVIOURAL BRAIN RESEARCH

XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons

(2013) Hung-Li Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

(2013) Karin E. Sandoval et al.   BRAIN RESEARCH

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Cul4B regulates neural progenitor cell growth

(2012) Helio C Liu et al.   BMC NEUROSCIENCE

Somatostatin receptor subtype-4 agonist NNC 26–9100 decreases extracellular and intracellular Aβ1–42 trimers

(2012) Karin E. Sandoval et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice

(2012) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Early-Life Stress Is Associated with Gender-Based Vulnerability to Epileptogenesis in Rat Pups

(2012) Sébastien Desgent et al.   PLoS One

Bak Foong Pills induce an analgesic effect by inhibiting nociception via the somatostatin pathway in mice

(2011) Dewi Kenneth Rowlands et al.   CELL BIOLOGY INTERNATIONAL

Traditional Chinese medicines and Alzheimer’s disease

(2011) Tzong-Yuan Wu et al.   Taiwanese Journal of Obstetrics & Gynecology

Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

(2010) D. A. Gimbel et al.   JOURNAL OF NEUROSCIENCE

Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain

(2010) Troy T. Rohn et al.   NEUROBIOLOGY OF DISEASE

The Role of the Ubiquitin Proteasome System in Ischemia and Ischemic Tolerance

(2009) Robert Meller   NEUROSCIENTIST

The ubiquitin-proteasome system in Alzheimer's disease

(2008) Salvatore Oddo   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE