Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

The Laminopathies and the Insights They Provide into the Structural and Functional Organization of the Nucleus

(2020) Xianrong Wong et al.   Annual Review of Genomics and Human Genetics

BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C–deficient mice

(2020) Gaelle Auguste et al.   JOURNAL OF CLINICAL INVESTIGATION

Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging

(2019) Wakam Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac microtubules in health and heart disease

(2019) Matthew A Caporizzo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Upregulation of Yy1 Suppresses Dilated Cardiomyopathy caused by Ttn insufficiency

(2019) Dan Liao et al.   Scientific Reports

The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

(2019) Tsui Han Loo et al.   eLife

A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte

(2019) Julie Heffler et al.   CIRCULATION RESEARCH

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Human Cardiac Gene Therapy

(2018) Kiyotake Ishikawa et al.   CIRCULATION RESEARCH

The Pathogenesis and Therapies of Striated Muscle Laminopathies

(2018) Astrid Brull et al.   Frontiers in Physiology

Lamin and the heart

(2017) Gabriella Captur et al.   HEART

Genetics and genomics of dilated cardiomyopathy and systolic heart failure

(2017) Upasana Tayal et al.   Genome Medicine

A Simplified, Langendorff-Free Method for Concomitant Isolation of Viable Cardiac Myocytes and Nonmyocytes From the Adult Mouse HeartNovelty and Significance

(2016) Matthew Ackers-Johnson et al.   CIRCULATION RESEARCH

ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene

(2016) Maria Chatzifrangkeskou et al.   HUMAN MOLECULAR GENETICS

Revisiting Frank-Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion

(2016) Christopher N. Toepfer et al.   JOURNAL OF PHYSIOLOGY-LONDON

The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

(2016) Samer G. Alam et al.   Scientific Reports

Tissue specific loss of A-type lamins in the gastrointestinal epithelium can enhance polyp size

(2015) Audrey S. Wang et al.   DIFFERENTIATION

Comparison of droplet digital PCR and conventional quantitative PCR for measuring EGFR gene mutation

(2015) BO ZHANG et al.   Experimental and Therapeutic Medicine

Isolation of single-base genome-edited human iPS cells without antibiotic selection

(2014) Yuichiro Miyaoka et al.   NATURE METHODS

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α

(2013) Tatiana V. Cohen et al.   HUMAN MOLECULAR GENETICS

Myosin Regulatory Light Chain (RLC) Phosphorylation Change as a Modulator of Cardiac Muscle Contraction in Disease

(2013) Christopher Toepfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dilated cardiomyopathy: the complexity of a diverse genetic architecture

(2013) Ray E. Hershberger et al.   Nature Reviews Cardiology

LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins

(2012) Brian A. Sosa et al.   CELL

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

(2012) Chia-Yen Chen et al.   CELL

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Shugo Tohyama et al.   Cell Stem Cell

Connecting the nucleus to the cytoskeleton by SUN–KASH bridges across the nuclear envelope

(2012) Erin C Tapley et al.   CURRENT OPINION IN CELL BIOLOGY

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Truncations of Titin Causing Dilated Cardiomyopathy

(2012) Daniel S. Herman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

(2012) J. C. Choi et al.   Science Translational Medicine

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death

(2011) Anne T. Bertrand et al.   HUMAN MOLECULAR GENETICS

Retro-orbital injections in mice

(2011) Tal Yardeni et al.   LAB ANIMAL

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A/C Gene

(2010) Wei Wu et al.   CIRCULATION

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

Dilated cardiomyopathy

(2010) John Lynn Jefferies et al.   LANCET

Diseases of the Nuclear Envelope

(2010) H. J. Worman et al.   Cold Spring Harbor Perspectives in Biology

Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA

(2009) Y.-H. Chi et al.   DEVELOPMENT

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

(2009) Farhana Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice

(2009) K. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Term Outcome and Risk Stratification in Dilated Cardiolaminopathies

(2008) Michele Pasotti et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY