Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection

The Innate Biologies of Adaptive Antigen Receptors

(2020) Adrian C. Hayday et al.   Annual Review of Immunology

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Skin Interface, a Key Player for Borrelia Multiplication and Persistence in Lyme Borreliosis

(2020) Quentin Bernard et al.   TRENDS IN PARASITOLOGY

Tick-Borne Flavivirus Inhibits Sphingomyelinase (IsSMase), a Venomous Spider Ortholog to Increase Sphingomyelin Lipid Levels for Its Survival in Ixodes scapularis Ticks

(2020) Pravesh Regmi et al.   Frontiers in Cellular and Infection Microbiology

Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick–Human Skin Interface

(2020) Wenshuo Zhou et al.   Frontiers in Cell and Developmental Biology

Dengue Virus Infection of Aedes aegypti Alters Extracellular Vesicle Protein Cargo to Enhance Virus Transmission

(2020) Alexander S. Gold et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of flavivirus infection in salivary gland cultures from male Ixodes scapularis ticks

(2020) Benjamin L. Kendall et al.   PLoS Neglected Tropical Diseases

Proteomic Analysis of Exosome-Like Vesicles Isolated From Saliva of the Tick Haemaphysalis longicornis

(2020) Mohsin Nawaz et al.   Frontiers in Cellular and Infection Microbiology

miRNA profile of extracellular vesicles isolated from saliva of Haemaphysalis longicornis tick

(2020) Mohsin Nawaz et al.   ACTA TROPICA

A Francisella tularensis Chitinase Contributes to Bacterial Persistence and Replication in Two Major U.S. Tick Vectors

(2020) Brenden G. Tully et al.   Pathogens

Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons

(2019) Wenshuo Zhou et al.   Emerging Microbes & Infections

Dissecting Flavivirus Biology in Salivary Gland Cultures from Fed and Unfed Ixodes scapularis (Black-Legged Tick)

(2019) Jeffrey M. Grabowski et al.   mBio

Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo

(2019) Frederik J. Verweij et al.   DEVELOPMENTAL CELL

Tick saliva and its role in pathogen transmission

(2019) Patricia A. Nuttall   WIENER KLINISCHE WOCHENSCHRIFT

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance

(2019) Adrian C. Hayday   JOURNAL OF IMMUNOLOGY

Ecology of Francisella tularensis

(2019) Sam R. Telford et al.   Annual Review of Entomology

Specialized Antitumor Functions for Skin γδ T Cells

(2018) Wendy L. Havran   JOURNAL OF IMMUNOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb

(2018) Ashish Vora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Blacklegged Tick, Ixodes scapularis : An Increasing Public Health Concern

(2018) Rebecca J. Eisen et al.   TRENDS IN PARASITOLOGY

Controlling ticks and tick-borne diseases…looking forward

(2018) José de la Fuente   Ticks and Tick-Borne Diseases

Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells

(2018) Wenshuo Zhou et al.   PLoS Pathogens

Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis

(2018) Kathryn E. Reif et al.   Scientific Reports

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance

(2018) Dana K. Shaw et al.   TRENDS IN IMMUNOLOGY

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

(2018) Jeroen Baardman et al.   Cell Reports

Characterization of the early local immune response toIxodes ricinustick bites in human skin

(2017) Martin Glatz et al.   EXPERIMENTAL DERMATOLOGY

In silico target network analysis of de novo-discovered, tick saliva-specific microRNAs reveals important combinatorial effects in their interference with vertebrate host physiology

(2017) Michael Hackenberg et al.   RNA

Amblyomma americanum ticks infected with in vitro cultured wild-type and mutants of Ehrlichia chaffeensis are competent to produce infection in naïve deer and dogs

(2017) Deborah C. Jaworski et al.   Ticks and Tick-Borne Diseases

Flavivirus Infection of Ixodes scapularis (Black-Legged Tick) Ex Vivo Organotypic Cultures and Applications for Disease Control

(2017) Jeffrey M. Grabowski et al.   mBio

IL-17-producing γδ T cells switch migratory patterns between resting and activated states

(2017) Duncan R. McKenzie et al.   Nature Communications

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

(2017) Xavier Sisquella et al.   Nature Communications

A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions

(2017) Gaelle Noel et al.   Scientific Reports

Tick-Host Range Adaptation: Changes in Protein Profiles in Unfed Adult Ixodes scapularis and Amblyomma americanum Saliva Stimulated to Feed on Different Hosts

(2017) Lucas Tirloni et al.   Frontiers in Cellular and Infection Microbiology

The Essential Role of Tick Salivary Glands and Saliva in Tick Feeding and Pathogen Transmission

(2017) Ladislav Šimo et al.   Frontiers in Cellular and Infection Microbiology

Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection

(2016) Marieke Pingen et al.   IMMUNITY

The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation

(2016) Xiaowei Wang et al.   INFECTION AND IMMUNITY

Genomic insights into the Ixodes scapularis tick vector of Lyme disease

(2016) Monika Gulia-Nuss et al.   Nature Communications

Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding

(2016) Tae Kwon Kim et al.   PLoS Neglected Tropical Diseases

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi

(2015) Mostafa Zamanian et al.   PLoS Neglected Tropical Diseases

An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum

(2015) Adela S. Oliva Chávez et al.   PLoS Pathogens

Reproducible and Quantitative Model of Infection of Dermacentor variabilis with the Live Vaccine Strain of Francisella tularensis

(2014) Jenifer Coburn et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Human Saliva-Derived Exosomes

(2014) Ayelet Zlotogorski-Hurvitz et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Feeding byAmblyomma maculatum(Acari: Ixodidae) EnhancesRickettsia parkeri(Rickettsiales: Rickettsiaceae) Infection in the Skin

(2014) Britton J. Grasperge et al.   JOURNAL OF MEDICAL ENTOMOLOGY

Identification of disulfide bond isomerase substrates reveals bacterial virulence factors

(2014) Guoping Ren et al.   MOLECULAR MICROBIOLOGY

ANTIDotE: anti-tick vaccines to prevent tick-borne diseases in Europe

(2014) Hein Sprong et al.   Parasites & Vectors

Ticks and tick-borne pathogens at the cutaneous interface: host defenses, tick countermeasures, and a suitable environment for pathogen establishment

(2013) Stephen Wikel   Frontiers in Microbiology

Anaplasma phagocytophilum Dihydrolipoamide Dehydrogenase 1 Affects Host-Derived Immunopathology during Microbial Colonization

(2012) Gang Chen et al.   INFECTION AND IMMUNITY

Mosquito Bite Delivery of Dengue Virus Enhances Immunogenicity and Pathogenesis in Humanized Mice

(2012) J. Cox et al.   JOURNAL OF VIROLOGY

Body-barrier surveillance by epidermal γδ TCRs

(2012) Grzegorz Chodaczek et al.   NATURE IMMUNOLOGY

Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry

(2012) Els J van der Vlist et al.   Nature Protocols

Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs

(2012) Dar M Heinze et al.   Parasites & Vectors

Autophagosomes induced by a bacterial Beclin 1 binding protein facilitate obligatory intracellular infection

(2012) H. Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-Related Oxidative Stress Compromises Endosomal Proteostasis

(2012) Elvira S. Cannizzo et al.   Cell Reports

Functions of skin-resident γδ T cells

(2011) Amanda S. MacLeod et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reduced Immune Response to Borrelia burgdorferi in the Absence of γδ T Cells

(2011) Cuixia Shi et al.   INFECTION AND IMMUNITY

Cutting Edge: Identification of a Motile IL-17-Producing    T Cell Population in the Dermis

(2011) E. E. Gray et al.   JOURNAL OF IMMUNOLOGY

Antialarmin Effect of Tick Saliva during the Transmission of Lyme Disease

(2010) Claire Marchal et al.   INFECTION AND IMMUNITY

Epidermal T Cells and Wound Healing

(2010) W. L. Havran et al.   JOURNAL OF IMMUNOLOGY

Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells

(2010) Anna Fialová et al.   MICROBES AND INFECTION

Quantum of infection of Francisella tularensis tularensis in host-seeking Dermacentor variabilis

(2010) Heidi K. Goethert et al.   Ticks and Tick-Borne Diseases

Blocking the secretion of saliva by silencing the HlYkt6 gene in the tick Haemaphysalis longicornis

(2009) Haiyan Gong et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Exosomes from human saliva as a source of microRNA biomarkers

(2009) A Michael et al.   ORAL DISEASES

Tracking antigen-driven responses by flow cytometry: Monitoring proliferation by dye dilution

(2008) Paul K. Wallace et al.   CYTOMETRY PART A

Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells

(2008) Lynn M Boyden et al.   NATURE GENETICS

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE