mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

(2020) Mi Li et al.   Protein & Cell

KAT5 acetylates cGAS to promote innate immune response to DNA virus

(2020) Ze-Min Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity

(2019) Ahmet Alptekin et al.   ONCOGENE

PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response

(2019) Tian Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

(2019) Xin Wu et al.   Nature Communications

Lysine Deacetylases and Regulated Glycolysis in Macrophages

(2018) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence

(2018) Carmen Mecca et al.   DISEASE MARKERS

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

(2017) Oliver D. K. Maddocks et al.   NATURE

Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus

(2016) Ming-Ming Hu et al.   IMMUNITY

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

(2014) Christiaan F. Labuschagne et al.   Cell Reports

Structure of the Homodimeric Glycine Decarboxylase P-protein fromSynechocystissp. PCC 6803 Suggests a Mechanism for Redox Regulation

(2013) Dirk Hasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Mitochondrial Acetylation Dynamics Highlights Prominent Sites of Metabolic Regulation

(2013) Amelia J. Still et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a molecular component of the mitochondrial acetyltransferase programme: a novel role for GCN5L1

(2012) Iain Scott et al.   BIOCHEMICAL JOURNAL

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Amino Acid Signaling in TOR Activation

(2011) Joungmok Kim et al.   Annual Review of Biochemistry

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Delivery of a normal baby after preimplantation genetic diagnosis for non-ketotic hyperglycinaemia

(2010) Ali Hellani et al.   REPRODUCTIVE BIOMEDICINE ONLINE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY