Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels

(2020) László Bálint et al.   Frontiers in Immunology

Phase 1 Lymfactin® Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema

(2020) Pauliina Hartiala et al.   Journal of Plastic Reconstructive and Aesthetic Surgery

Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth

(2020) Kitti Szoták-Ajtay et al.   Frontiers in Bioengineering and Biotechnology

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

(2019) Itishri Sahu et al.   MOLECULAR THERAPY

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

(2019) Hong-Xia Zhang et al.   MOLECULAR THERAPY

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

(2019) Ji Hoon Ahn et al.   NATURE

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases

(2018) Zeljka Trepotec et al.   MOLECULAR THERAPY

mRNA-Based Protein Replacement Therapy for the Heart

(2018) Ajit Magadum et al.   MOLECULAR THERAPY

Organ-specific lymphatic vasculature: From development to pathophysiology

(2017) Tatiana V. Petrova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

State of play and clinical prospects of antibody gene transfer

(2017) Kevin Hollevoet et al.   Journal of Translational Medicine

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system

(2016) Ines Martinez-Corral et al.   ANGIOGENESIS

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Orianne Henri et al.   CIRCULATION

Lymphatic System in Cardiovascular Medicine

(2016) Aleksanteri Aspelund et al.   CIRCULATION RESEARCH

Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD

(2016) Hung M. Bui et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study

(2015) Mikko T. Visuri et al.   ANGIOGENESIS

Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives

(2015) Jennifer Dumont et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

(2015) Jean-Charles Nault et al.   NATURE GENETICS

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

(2014) Michael Jeltsch et al.   CIRCULATION

New developments in clinical aspects of lymphatic disease

(2014) Peter S. Mortimer et al.   JOURNAL OF CLINICAL INVESTIGATION

The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment

(2014) Miklós Kovács et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic function is required prenatally for lung inflation at birth

(2014) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic Vessels Are Essential for the Removal of Cholesterol from Peripheral Tissues by SR-BI-Mediated Transport of HDL

(2013) Hwee Ying Lim et al.   Cell Metabolism

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

(2013) Catherine Martel et al.   JOURNAL OF CLINICAL INVESTIGATION

Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis

(2013) Tracey DiSipio et al.   LANCET ONCOLOGY

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Detection of lymphangiogenesis by near-infrared fluorescence imaging and responses to VEGF-C during healing in a mouse full-dermis thickness wound model

(2013) Mary A. Hall et al.   WOUND REPAIR AND REGENERATION

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Biological Basis of Therapeutic Lymphangiogenesis

(2011) Camilla Norrmén et al.   CIRCULATION

Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

(2011) Markku Lähteenvuo et al.   CIRCULATION

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Therapeutic Responses to Exogenous VEGF-C Administration in Experimental Lymphedema: Immunohistochemical and Molecular Characterization

(2009) Da Pan Jin et al.   Lymphatic Research and Biology

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

The Clinical Spectrum of Lymphatic Disease

(2008) Kavita Radhakrishnan et al.   Annals of the New York Academy of Sciences