Biological Basis of Therapeutic Lymphangiogenesis

Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema

(2011) Markku Lähteenvuo et al.   CIRCULATION

GJC2 Missense Mutations Cause Human Lymphedema

(2010) Robert E. Ferrell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lipedema: An inherited condition

(2010) Anne H. Child et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

(2010) Fei Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin

(2010) L. N. Cueni et al.   BLOOD

Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis

(2010) S. Nakao et al.   BLOOD

Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation

(2010) P. Uhrin et al.   BLOOD

Structural determinants of vascular endothelial growth factor-D receptor binding and specificity

(2010) V.-M. Leppanen et al.   BLOOD

Prox1 expression is negatively regulated by miR-181 in endothelial cells

(2010) J. Kazenwadel et al.   BLOOD

Role of synectin in lymphatic development in zebrafish and frogs

(2010) K. Hermans et al.   BLOOD

Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

(2010) C. C. Bertozzi et al.   BLOOD

Lymphotoxin-alpha contributes to lymphangiogenesis

(2010) R. H. Mounzer et al.   BLOOD

Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization

(2010) Denis Tvorogov et al.   CANCER CELL

In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography

(2010) V. Mumprecht et al.   CANCER RESEARCH

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

Chemotrap-1: An Engineered Soluble Receptor That Blocks Chemokine-Induced Migration of Metastatic Cancer Cells In vivo

(2010) S. Lanati et al.   CANCER RESEARCH

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

(2010) S. T. Proulx et al.   CANCER RESEARCH

Microvascular fluid exchange and the revised Starling principle

(2010) J. Rodney Levick et al.   CARDIOVASCULAR RESEARCH

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

(2010) Maija Bry et al.   CIRCULATION

Platelets Play an Essential Role in Separating the Blood and Lymphatic Vasculatures During Embryonic Angiogenesis

(2010) Laura Carramolino et al.   CIRCULATION RESEARCH

Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src–Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity

(2010) Federico Galvagni et al.   CIRCULATION RESEARCH

Regulation of Developmental Lymphangiogenesis by Syk+ Leukocytes

(2010) Ruben Böhmer et al.   DEVELOPMENTAL CELL

Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development

(2010) P. Saharinen et al.   GENES & DEVELOPMENT

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells

(2010) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo

(2010) Liang Song et al.   JOURNAL OF BIOMEDICAL OPTICS

Tbx1 regulatesVegfr3and is required for lymphatic vessel development

(2010) Li Chen et al.   JOURNAL OF CELL BIOLOGY

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development

(2010) Fu-Jung Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Indocyanine Green and Lymphatic Imaging: Current Problems

(2010) Anatoliy A. Gashev et al.   Lymphatic Research and Biology

Lymphangioleiomyomatosis: A Disease Involving the Lymphatic System

(2010) Kuniaki Seyama et al.   Lymphatic Research and Biology

Lymphatic Dysfunction, Not Aplasia, Underlies Milroy Disease

(2010) Russell H. Mellor et al.   MICROCIRCULATION

miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo

(2010) D. M. Leslie Pedrioli et al.   MOLECULAR AND CELLULAR BIOLOGY

Vascular endothelial growth factor B controls endothelial fatty acid uptake

(2010) Carolina E. Hagberg et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3

(2010) Matthias Rinderknecht et al.   PLoS One

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phasic contractions of rat mesenteric lymphatics increase basal and phasic nitric oxide generation in vivo

(2009) H. Glenn Bohlen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Liprin  1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity

(2009) C. Norrmen et al.   BLOOD

ALK1 signaling regulates early postnatal lymphatic vessel development

(2009) K. Niessen et al.   BLOOD

Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF- B and Prox1

(2009) M. J. Flister et al.   BLOOD

Activated Forms of VEGF-C and VEGF-D Provide Improved Vascular Function in Skeletal Muscle

(2009) Andrey Anisimov et al.   CIRCULATION RESEARCH

Lymphatic imaging in humans with near-infrared fluorescence

(2009) John C Rasmussen et al.   CURRENT OPINION IN BIOTECHNOLOGY

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

(2009) Marja Lohela et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of lymphatic-blood vessel separation by endothelial Rac1

(2009) G. D'Amico et al.   DEVELOPMENT

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries

(2009) B. M. Hogan et al.   DEVELOPMENT

Integrin-α9 Is Required for Fibronectin Matrix Assembly during Lymphatic Valve Morphogenesis

(2009) Eleni Bazigou et al.   DEVELOPMENTAL CELL

Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

(2009) Carla Mouta-Bellum et al.   DEVELOPMENTAL DYNAMICS

COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction

(2009) Tomoko Yamazaki et al.   GENES TO CELLS

Tumor metastasis and the lymphatic vasculature

(2009) Jonathan P. Sleeman et al.   INTERNATIONAL JOURNAL OF CANCER

FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1

(2009) Camilla Norrmén et al.   JOURNAL OF CELL BIOLOGY

Lymphangiogenesis and cancer metastasis

(2009) Viviane Mumprecht et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array

(2009) Liang Song et al.   MEDICAL PHYSICS

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

(2009) Marielle Alders et al.   NATURE GENETICS

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

(2009) Romulo J C Albuquerque et al.   NATURE MEDICINE

Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism

(2009) Agnes Machnik et al.   NATURE MEDICINE

Filariasis and lymphoedema

(2009) K. M. PFARR et al.   PARASITE IMMUNOLOGY

Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation

(2009) S. P. Herbert et al.   SCIENCE

Lymphangiogenesis and Lymphatic Remodeling Induced by Filarial Parasites: Implications for Pathogenesis

(2009) Sasisekhar Bennuru et al.   PLoS Pathogens

Phenotypic Characterization of Primary Lymphedema

(2008) Fiona Connell et al.   Annals of the New York Academy of Sciences

Molecular Regulation of Lymphatic Contractility

(2008) Mariappan Muthuchamy et al.   Annals of the New York Academy of Sciences

Research Perspectives in Inherited Lymphatic Disease

(2008) Robert E. Ferrell et al.   Annals of the New York Academy of Sciences

New Horizons for Imaging Lymphatic Function

(2008) Ruchi Sharma et al.   Annals of the New York Academy of Sciences

Molecular Biology and Pathology of Lymphangiogenesis

(2008) Terhi Karpanen et al.   Annual Review of Pathology-Mechanisms of Disease

Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate

(2008) S. Lee et al.   BLOOD

Lymphatic drainage in the muscle and subcutis of the arm after breast cancer treatment

(2008) Anthony W. B. Stanton et al.   BREAST CANCER RESEARCH AND TREATMENT

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Calcium carbonate nanoparticle delivering vascular endothelial growth factor-C siRNA effectively inhibits lymphangiogenesis and growth of gastric cancer in vivo

(2008) X-w He et al.   CANCER GENE THERAPY

Adrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema

(2008) D. Jin et al.   CARDIOVASCULAR RESEARCH

The Renaissance of Vascular Endothelial Growth Factor, Part B

(2008) Wolfgang Schaper   CIRCULATION RESEARCH

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

(2008) Terhi Karpanen et al.   CIRCULATION RESEARCH

Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis

(2008) Achim Hoerauf   CURRENT OPINION IN INFECTIOUS DISEASES

Phospholipase C 2 is necessary for separation of blood and lymphatic vasculature in mice

(2008) H. Ichise et al.   DEVELOPMENT

Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice

(2008) Michael Dellinger et al.   DEVELOPMENTAL BIOLOGY

Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos

(2008) Masanori Hirashima et al.   DEVELOPMENTAL BIOLOGY

Primary non-syndromic lymphoedema (Meige disease) is not caused by mutations in FOXC2

(2008) Tayebeh Rezaie et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Lymphangioleiomyomatosis: A review

(2008) Donald W. Hohman et al.   European Journal of Internal Medicine

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity

(2008) N. C. Johnson et al.   GENES & DEVELOPMENT

Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas

(2008) F. C. Connell et al.   HUMAN GENETICS

Lymphatic Endothelial Cells, Lymphedematous Lymphangiogenesis, and Molecular Control of Edema Formation

(2008) Rui-Cheng Ji   Lymphatic Research and Biology

Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos

(2008) P. Haiko et al.   MOLECULAR AND CELLULAR BIOLOGY

Emilin1 Deficiency Causes Structural and Functional Defects of Lymphatic Vasculature

(2008) C. Danussi et al.   MOLECULAR AND CELLULAR BIOLOGY

Sox18 induces development of the lymphatic vasculature in mice

(2008) Mathias François et al.   NATURE

Turner Syndrome

(2008) M. L. Loscalzo   PEDIATRICS IN REVIEW

The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity

(2007) Yuka Ichikawa-Shindo et al.   JOURNAL OF CLINICAL INVESTIGATION

Adrenomedullin signaling is necessary for murine lymphatic vascular development

(2007) Kimberly L. Fritz-Six et al.   JOURNAL OF CLINICAL INVESTIGATION