PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure

Cooperative function of synaptophysin and synapsin in the generation of synaptic vesicle-like clusters in non-neuronal cells

(2021) Daehun Park et al.   Nature Communications

Phase separation at the synapse

(2020) Xudong Chen et al.   NATURE NEUROSCIENCE

Assembly of the presynaptic active zone

(2020) Javier Emperador-Melero et al.   CURRENT OPINION IN NEUROBIOLOGY

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry

(2020) Richard G. Held et al.   NEURON

ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals

(2020) Hajnalka Nyitrai et al.   Cell Reports

Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates

(2020) Xiandeng Wu et al.   MOLECULAR CELL

Assembly of synaptic active zones requires phase separation of scaffold molecules

(2020) Nathan A. McDonald et al.   NATURE

RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation

(2019) Xiandeng Wu et al.   MOLECULAR CELL

RIMB-1/RIM-binding protein and UNC-10/RIM redundantly regulate presynaptic localization of the voltage-gated calcium channel in C. elegans

(2019) Yuto Kushibiki et al.   JOURNAL OF NEUROSCIENCE

Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function

(2019) Nelson Rebola et al.   NEURON

RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses

(2019) Marisa M Brockmann et al.   eLife

RIM C 2 B Domains Target Presynaptic Active Zone Functions to PIP 2 -Containing Membranes

(2018) Arthur P.H. de Jong et al.   NEURON

IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding

(2018) Bálint Mészáros et al.   NUCLEIC ACIDS RESEARCH

Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses

(2018) Man Yan Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A liquid phase of synapsin and lipid vesicles

(2018) Dragomir Milovanovic et al.   SCIENCE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

(2018) Menglong Zeng et al.   CELL

Synaptic weight set by Munc13-1 supramolecular assemblies

(2017) Hirokazu Sakamoto et al.   NATURE NEUROSCIENCE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission

(2017) Suneel Reddy-Alla et al.   NEURON

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity

(2016) Menglong Zeng et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors

(2016) Ai-Hui Tang et al.   NATURE

Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling

(2016) Mathias A Böhme et al.   NATURE NEUROSCIENCE

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs

(2016) Claudio Acuna et al.   NEURON

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking

(2016) Shan Shan H. Wang et al.   NEURON

Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity

(2016) Arthur P. H. de Jong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

(2016) M. Katharina Grauel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains

(2016) Richard G Held et al.   eLife

The Active Zone Protein Family ELKS Supports Ca2+ Influx at Nerve Terminals of Inhibitory Hippocampal Neurons

(2014) C. Liu et al.   JOURNAL OF NEUROSCIENCE

The Morphological and Molecular Nature of Synaptic Vesicle Priming at Presynaptic Active Zones

(2014) Cordelia Imig et al.   NEURON

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission

(2013) Samantha A. Spangler et al.   JOURNAL OF CELL BIOLOGY

Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α

(2013) Poh Hui Chia et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Liprin-  controls stress fiber formation by binding to mDia and regulating its membrane localization

(2012) S. Sakamoto et al.   JOURNAL OF CELL SCIENCE

RIM Controls Homeostatic Plasticity through Modulation of the Readily-Releasable Vesicle Pool

(2012) M. Muller et al.   JOURNAL OF NEUROSCIENCE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Differential expression of liprin-α family proteins in the brain suggests functional diversification

(2011) Samantha A. Spangler et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins

(2011) Magdalena Zürner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release

(2011) K. S. Y. Liu et al.   SCIENCE

Presynaptic signal transduction pathways that modulate synaptic transmission

(2009) Arthur PH de Jong et al.   CURRENT OPINION IN NEUROBIOLOGY

Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans

(2009) O. I. Wagner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mouse and human Liprin-α family of scaffolding proteins: Genomic organization, expression profiling and regulation by alternative splicing

(2008) Magdalena Zürner et al.   GENOMICS