UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer

Immunotherapy in colorectal cancer: rationale, challenges and potential

(2019) Karuna Ganesh et al.   Nature Reviews Gastroenterology & Hepatology

Gemcitabine and Oxaliplatin Chemotherapy or Surveillance in Resected Biliary Tract Cancer (PRODIGE 12-ACCORD 18-UNICANCER GI): A Randomized Phase III Study

(2019) Julien Edeline et al.   JOURNAL OF CLINICAL ONCOLOGY

Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

(2019) Shuxiong Zeng et al.   BMC CANCER

UPF1 inhibits the hepatocellular carcinoma progression by targeting long non-coding RNA UCA1

(2019) Yongli Zhou et al.   Scientific Reports

Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer

(2019) Daniel Wai-Hung Ho et al.   CANCER LETTERS

Molecular mechanisms of topoisomerase 2 DNA–protein crosslink resolution

(2019) Amanda A. Riccio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II

(2019) Joyce H. Lee et al.   Genes

Topoisomerases as anticancer targets

(2018) Justine L. Delgado et al.   BIOCHEMICAL JOURNAL

CCR6 promotes tumor angiogenesis via the AKT/NF-κB/VEGF pathway in colorectal cancer

(2018) Cong-cong Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway

(2018) Yao-fei Pei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of chemotherapy in localized and locally advanced rectal cancer: A systematic revision

(2018) Susana Roselló et al.   CANCER TREATMENT REVIEWS

Cancer incidence and mortality in China, 2014

(2018) Wanqing Chen et al.   Chinese Journal of Cancer Research

Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A

(2018) Rui Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

miR-145 Antagonizes SNAI1-Mediated Stemness and Radiation Resistance in Colorectal Cancer

(2018) Yun Zhu et al.   MOLECULAR THERAPY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer

(2018) Hwa Jin Kim et al.   Cell Death & Disease

Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

(2018) A’dem Bokhari et al.   Oncogenesis

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity

(2017) Qing Feng et al.   MOLECULAR CELL

Colorectal cancer heterogeneity and targeted therapy: Clinical implications, challenges and solutions for treatment resistance

(2017) Zhenhua Zhai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients

(2016) Jan Dimberg et al.   APMIS

The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma

(2016) Lei Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis

(2016) Mustafa Suker et al.   LANCET ONCOLOGY

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance

(2015) E. Martinez-Balibrea et al.   MOLECULAR CANCER THERAPEUTICS

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Direct control of type IIA topoisomerase activity by a chromosomally encoded regulatory protein

(2014) S. M. Vos et al.   GENES & DEVELOPMENT

The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation

(2014) D Hind et al.   HEALTH TECHNOLOGY ASSESSMENT

Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to Irinotecan

(2014) C. Meisenberg et al.   MOLECULAR CANCER THERAPEUTICS

The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma

(2014) Chen Liu et al.   NATURE MEDICINE

Topoisomerase IIα in chromosome instability and personalized cancer therapy

(2014) T Chen et al.   ONCOGENE

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Gene regulation and priming by topoisomerase IIα in embryonic stem cells

(2013) Sudhir Thakurela et al.   Nature Communications

Cancer Resistance to Type II Topoisomerase Inhibitors

(2012) P. Pilati et al.   CURRENT MEDICINAL CHEMISTRY

Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

(2012) A. Kreso et al.   SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

Casein kinase I  /  phosphorylates topoisomerase II  at serine-1106 and modulates DNA cleavage activity

(2008) A. G. Grozav et al.   NUCLEIC ACIDS RESEARCH

YacG from Escherichia coli is a specific endogenous inhibitor of DNA gyrase

(2008) Sugopa Sengupta et al.   NUCLEIC ACIDS RESEARCH

BRCA1-Mediated Ubiquitination Inhibits Topoisomerase IIα Activity in Response to Oxidative Stress

(2007) Hirokuni Shinagawa et al.   ANTIOXIDANTS & REDOX SIGNALING