Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1

miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment

(2020) Ilaria Conti et al.   Cells

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes

(2019) Sangiliyandi Gurunathan et al.   Cells

MiR-135b delivered by gastric tumor exosomes inhibits FOXO1 expression in endothelial cells and promotes angiogenesis

(2019) Ming Bai et al.   MOLECULAR THERAPY

Exosomes from Adipose-Derived Stem Cells (ADSCs) Overexpressing miR-21 Promote Vascularization of Endothelial Cells

(2019) Yang An et al.   Scientific Reports

Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases

(2019) Carl Randall Harrell et al.   Cells

KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease

(2018) Cinzia Antognelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway

(2018) Yoshiro Itatani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

(2018) Yingkuan Shao et al.   CARCINOGENESIS

The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation

(2018) Yitang Wang et al.   FASEB JOURNAL

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Exposure to Concentrated Ambient Fine Particulate Matter Induces Vascular Endothelial Dysfunction via miR-21

(2017) Jianwei Dai et al.   International Journal of Biological Sciences

Different miR-21-3p isoforms and their different features in colorectal cancer

(2017) Weijuan Jiao et al.   INTERNATIONAL JOURNAL OF CANCER

Exosomes and Exosomal MicroRNAs in Prostate Cancer Radiation Therapy

(2017) Bijaya Malla et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Role of miR-21 on vascular endothelial cells in the protective effect of renal delayed ischemic preconditioning

(2017) Xialian Xu et al.   Molecular Medicine Reports

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Circulating Exosomal MicroRNA-21 as a Biomarker in Each Tumor Stage of Colorectal Cancer

(2017) Mitsuo Tsukamoto et al.   ONCOLOGY

The clinical role of microRNA-21 as a promising biomarker in the diagnosis and prognosis of colorectal cancer: a systematic review and meta-analysis

(2017) Qiliang Peng et al.   Oncotarget

MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression

(2016) Chenli Li et al.   BMC CANCER

Common genetic variation in ETV6 is associated with colorectal cancer susceptibility

(2016) Meilin Wang et al.   Nature Communications

MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1, SOCS6, and PTEN

(2016) Xinying Xue et al.   Oncotarget

miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats

(2015) Xintong Ge et al.   BRAIN RESEARCH

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

miR-21 Is Linked to Glioma Angiogenesis

(2015) Simon Kjær Hermansen et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer

(2015) Yuling Li et al.   Oncotarget

Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells

(2014) Yifang Wei et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer

(2014) John K. Chan et al.   GYNECOLOGIC ONCOLOGY

Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

(2014) Hiroko Ogata-Kawata et al.   PLoS One

CCM1 and the second life of proteins in adhesion complexes

(2014) Maaike CW van den Berg et al.   Cell Adhesion & Migration

miR-21 coordinates tumor growth and modulates KRIT1 levels

(2013) Francesca Orso et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vascular Permeability and Drug Delivery in Cancers

(2013) Sandy Azzi et al.   Frontiers in Oncology

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps

(2011) Chung Wah Wu et al.   GUT

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

Locked Nucleic Acid In situ Hybridization Analysis of miR-21 Expression during Colorectal Cancer Development

(2009) N. Yamamichi et al.   CLINICAL CANCER RESEARCH

Rap1 and its effector KRIT1/CCM1 regulate  -catenin signaling

(2009) A. J. Glading et al.   Disease Models & Mechanisms