TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

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TWEAK/Fn14 axis is an important player in fibrosis

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LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

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Cancer statistics, 2018

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Systemic treatment of pancreatic cancer revisited

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Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer

(2018) Lusheng Wei et al.   Cell Death & Disease

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial

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Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

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Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

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Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

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EMT: 2016

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Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation

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Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma

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Pancreatic cancer

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2016 update of the PRIDE database and its related tools

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Identification of New Mechanisms of Cellular Response to Chemotherapy by Tracking Changes in Post-Translational Modifications by Ubiquitin and Ubiquitin-Like Proteins

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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

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Insidious Changes in Stromal Matrix Fuel Cancer Progression

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Mesenchymal–endothelial transition contributes to cardiac neovascularization

(2014) Eric Ubil et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

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Fibroblast-mediated drug resistance in cancer

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EndMT contributes to the onset and progression of cerebral cavernous malformations

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Microenvironmental regulation of tumor progression and metastasis

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Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

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Combining two strategies to improve perfusion and drug delivery in solid tumors

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The Pancreas Cancer Microenvironment

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Tie1 deficiency induces endothelial–mesenchymal transition

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The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

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Observational studies on the risk of cancer associated with tumor necrosis factor inhibitors in rheumatoid arthritis: A review of their methodologies and results

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Hallmarks of Cancer: The Next Generation

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Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis

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Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Conversion of vascular endothelial cells into multipotent stem-like cells

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Epithelial-Mesenchymal Transitions in Development and Disease

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The basics of epithelial-mesenchymal transition

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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Tumor-induced upregulation of Twist, Snail, and Slug represses the activity of the human VE-cadherin promoter

(2008) Dayami Lopez et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of endothelial-to-mesenchymal transition in cancer progression

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Anti-Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis

(2008) J.-H. Egberts et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer

(2008) Kai-Xing Ai et al.   WORLD JOURNAL OF GASTROENTEROLOGY