Dietary supplementation of camel whey protein attenuates heat stress-induced liver injury by inhibiting NLRP3 inflammasome activation through the HMGB1/RAGE signalling pathway

Hydrolyzed camel whey protein alleviated heat stress-induced hepatocyte damage by activated Nrf2/HO-1 signaling pathway and inhibited NF-κB/NLRP3 axis

(2021) Donghua Du et al.   CELL STRESS & CHAPERONES

Inhibition of HMGB1 improves necrotizing enterocolitis by inhibiting NLRP3 via TLR4 and NF-κB signaling pathways

(2019) Renqiang Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evaluation of the hepatoprotective effect of combination between fermented camel milk and Rosmarinus officinalis leaves extract against CCl4 induced liver toxicity in mice

(2019) Houda Hamed et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

HSP70 is a negative regulator of NLRP3 inflammasome activation

(2019) Pierre Martine et al.   Cell Death & Disease

Caspase-1 initiates apoptosis in the absence of gasdermin D

(2019) Kohsuke Tsuchiya et al.   Nature Communications

Screening of the Hepatotoxic Components in Fructus Gardeniae and Their Effects on Rat Liver BRL-3A Cells

(2019) Chunnan Li et al.   MOLECULES

Theanine supplementation prevents liver injury and heat shock response by normalizing hypothalamic-pituitaryadrenal axis hyperactivity in mice subjected to whole body heat stress

(2018) Dongxu Wang et al.   Journal of Functional Foods

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Camel whey protein protects lymphocytes from apoptosis via the PI3K–AKT, NF-κB, ATF-3, and HSP-70 signaling pathways in heat-stressed male mice

(2017) Gamal Badr et al.   Biochemistry and Cell Biology

Short communication: Camel milk ameliorates inflammatory responses and oxidative stress and downregulates mitogen-activated protein kinase signaling pathways in lipopolysaccharide-induced acute respiratory distress syndrome in rats

(2016) Wei-Wei Zhu et al.   JOURNAL OF DAIRY SCIENCE

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

(2015) Yan Geng et al.   JOURNAL OF HEPATOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Camel’s milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress

(2014) Hany H. Arab et al.   FOOD AND CHEMICAL TOXICOLOGY

Limiting prolonged inflammation during proliferation and remodeling phases of wound healing in streptozotocin-induced diabetic rats supplemented with camel undenatured whey protein

(2013) Hossam Ebaid et al.   BMC IMMUNOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

HMGB1 activity inhibition alleviating liver injury in heatstroke

(2013) HuaSheng Tong et al.   Journal of Trauma and Acute Care Surgery

Camel’s milk alleviates alcohol-induced liver injury in rats

(2012) Hebatallah A. Darwish et al.   FOOD AND CHEMICAL TOXICOLOGY

High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

(2012) Wei Yan et al.   HEPATOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats

(2010) Satoshi Hagiwara et al.   INFLAMMATION RESEARCH

Regulation of apoptosis in nucleus pulposus cells by optimized exogenous Bcl-2 overexpression

(2010) Hideki Sudo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

RECOMBINANT THROMBOMODULIN PREVENTS HEATSTROKE BY INHIBITION OF HIGH-MOBILITY GROUP BOX 1 PROTEIN IN SERA OF RATS

(2010) Satoshi Hagiwara et al.   SHOCK

Isolation of lactoferrin from milk of different species: Calorimetric and antimicrobial studies

(2008) Celia Conesa et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY