Article
Medicine, Research & Experimental
Tung-Sheng Chen, Yi-An Lai, Yun-Ju Lai, Chiang-Ting Chien
Summary: Stem cells pre-incubated with green tea theanine showed enhanced cell capabilities and better therapeutic effects on rats with liver injury, indicating the potential of theanine in stem cell therapy for liver diseases. Increased paracrine VEGF secretion from theanine pre-incubated stem cells plays a crucial role in liver regeneration, suggesting the need for future clinical studies to further verify these experimental findings.
Review
Oncology
Enzo M. Scutigliani, Yongxin Liang, Hans Crezee, Roland Kanaar, Przemek M. Krawczyk
Summary: Hyperthermia is a method of exposing tumors to elevated temperatures to enhance the effects of chemotherapy and radiotherapy. However, its efficacy is limited by factors such as heat stress response. Targeting this cellular defense mechanism may improve the effectiveness of hyperthermia-based therapies.
Article
Agriculture, Dairy & Animal Science
Zuo Wang, Lingmei Zhang, Zhicai Li, Yuannian Yu, Lingyuan Yang, Peihua Zhang, Weijun Shen, Fachun Wan, Jianhua He, Wenjun Xiao, Dasheng Yang, Zhiliang Tan, Shaoxun Tang
Summary: The study revealed that L-theanine could mitigate the detrimental effects of heat stress on dairy cows by reducing LPS translocation and accumulation, as well as alleviating inflammatory reactions in dairy cows during heat stress. Further research is needed to explore the underlying mechanisms of L-theanine in altering LPS and alleviating inflammation.
Article
Environmental Sciences
Shao-Shuai Bi, Milton Talukder, Xue-Tong Sun, Mei-Wei Lv, Jing Ge, Cong Zhang, Jin-Long Li
Summary: This study assessed the neurotoxic effects of chronic cadmium (Cd) exposure on the chicken cerebellum and investigated the expression of genes related to the heat-shock response. The results showed that Cd exposure led to clinical symptoms of ataxia in the chickens, decreased the number of Purkinje cells, and induced degeneration of Purkinje cells. Cd exposure also affected the expression of heat-shock factors and proteins. These findings shed light on the toxic effects of Cd on the cerebellum and provide evidence for the health risks posed by Cd exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Lina Bai, Peng Shi, Kun Jia, Hua Yin, Jilin Xu, Xiaojun Yan, Kai Liao
Summary: The toxicity of triflumizole (TFZ) was investigated in zebrafish to understand its potential risks in the aquatic environment. The study found that TFZ exposure affected the development of zebrafish and resulted in disturbances in oxidative stress, heat shock response, inflammation, and lipid synthesis. These findings provide important insights into the potential risks of TFZ to the aquatic ecosystem.
Article
Biochemistry & Molecular Biology
Urszula Korotko, Karolina Chwialkowska, Izabela Sanko-Sawczenko, Miroslaw Kwasniewski
Summary: The study found that under heat stress, the level of DNA methylation decreases in Arabidopsis thaliana, especially after returning to normal conditions. Analysis of gene ontology enrichment and regulatory pathways showed that genes with differential DNA methylation are mainly associated with stress responses, including heat stress. This indicates an active demethylation phenomenon rather than passive demethylation under the influence of heat stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Article
Biochemistry & Molecular Biology
Yanping Wu, Baikui Wang, Li Tang, Yuanhao Zhou, Qi Wang, Li Gong, Jiajia Ni, Weifen Li
Summary: The study revealed that the probiotic Bacillus SC06 alleviates oxidative stress-induced liver injuries by optimizing the composition, metabolic pathways, and pathogenic replication and secretion of gut microbiota. This suggests a promising strategy for preventing liver diseases through targeting gut microbiota.
Article
Biochemistry & Molecular Biology
Abhijnya Kanugovi Vijayavittal, Pankaj Kumar, Sreedevi Sugunan, Chitra Joseph, Bharath Devaki, Khanderao Paithankar, Sreedhar Amere Subbarao
Summary: The heat shock transcription factors HSF1 and HSF2 play different roles in regulating transcription in cells. HSF2 acts as an upstream regulator in heat-induced autophagy response by activating the transcription of BTG2 and SOD2. This finding reveals the important role of HSF2 in cellular redox sensing.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Robin Barten, Michelle Kleisman, Giulia D'Ermo, Harm Nijveen, Rene H. Wijffels, Maria J. Barbosa
Summary: High temperatures negatively affect cell physiology and reduce growth and productivity in photobioreactors. Supra-optimal temperature causes cell cycle arrest and changes in metabolic activity. It also affects the composition of fatty acids and pigments in microalgae. Gene expression related to photosynthesis, carbon fixation, and metabolism is downregulated, while genes related to proteasome, autophagy, and endocytosis are upregulated.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Simeng Chen, Jie Zhou, Chidimma Juliet Igbokwe, Yuqing Duan, Meihong Cai, Yuanqing He, Haihui Zhang
Summary: This study investigated the effect and potential mechanism of RDPEER, an antioxidant oligopeptide derived from watermelon seeds, on heat stress-induced liver injury and cell damage. The results showed that supplementation with RDPEER attenuated hepatocyte injury by increasing cell viability, reducing ROS production, improving antioxidant enzyme activity, and decreasing MDA content. RDPEER also inhibited HPA axis hyperactivity, transaminase activity, and inflammatory factor levels, while activating the endogenous antioxidant pathway and reducing inflammatory factor transcription and heat shock protein expression. Overall, RDPEER supplementation enhanced antioxidant capacity and alleviated liver damage caused by heat stress, suggesting its potential use in nutritional interventions.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Neurosciences
Yunpeng Liu, Danya Sanderson, M. Firoz Mian, Karen-Anne McVey Neufeld, Paul Forsythe
Summary: The study investigated the impact of subdiaphragmatic vagotomy on the anxiolytic effects of L.rhamnosus and found that the vagus nerve plays a crucial role in modulating immune changes associated with this effect. Vagotomy prevented the anxiolytic effects, immune cell increase, and altered microglia activation in the hippocampus, highlighting the importance of vagal signaling in the microbiota-gut-brain axis.
Review
Plant Sciences
Fengxia Tian, Xiao-Li Hu, Tao Yao, Xiaohan Yang, Jin-Gui Chen, Meng-Zhu Lu, Jin Zhang
Summary: Global warming poses a threat to plant life, with heat shock response (HSR) playing a crucial role in protecting cellular homeostasis, especially for perennial trees. Understanding the molecular mechanisms of HSR in woody plants is essential for predicting how they will respond to climate changes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Environmental Sciences
Bin Pan, Minjie Chen, Xuan Zhang, Shuai Liang, Xiaobo Qin, Lianglin Qiu, Qi Cao, Renzhen Peng, Shimin Tao, Zhouzhou Li, Yaning Zhu, Haidong Kan, Yanyi Xu, Zhekang Ying
Summary: This study found that ambient PM2.5 exposure can activate the HPA axis and mediate PM2.5-induced pulmonary inflammation, providing insights into the contribution of central neurohormonal mechanisms in modulating adverse health effects caused by exposure to PM2.5.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Agriculture, Multidisciplinary
Sha Liu, Bin Wang, Ling Lin, Wei Xu, Zhi-Hua Gong, Wen-Jun Xiao
Summary: L-Theanine can alleviate heat stress by modulating gut microbiota, metabolites, and immunity, indicating its potential as a natural active ingredient for anti-heat stress food products.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Endocrinology & Metabolism
Frank Qian, Andres V. Ardisson Korat, Fumiaki Imamura, Matti Marklund, Nathan Tintle, Jyrki K. Virtanen, Xia Zhou, Julie K. Bassett, Heidi Lai, Yoichiro Hirakawa, Kuo-Liong Chien, Alexis C. Wood, Maria Lankinen, Rachel A. Murphy, Cecilia Samieri, Kamalita Pertiwi, Vanessa D. de Mello, Weihua Guan, Nita G. Forouhi, Nick Wareham, Frank B. Hu, Ulf Riserus, Lars Lind, William S. Harris, Aladdin H. Shadyab, Jennifer G. Robinson, Lyn M. Steffen, Allison Hodge, Graham G. Giles, Toshiharu Ninomiya, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindstrom, Markku Laakso, David S. Siscovick, Catherine Helmer, Johanna M. Geleijnse, Jason H. Y. Wu, Amanda Fretts, Rozenn N. Lemaitre, Renata Micha, Dariush Mozaffarian, Qi Sun
Summary: A global consortium of 20 prospective studies involving 65,147 participants found that higher circulating biomarkers of seafood-derived n-3 fatty acids were associated with lower risk of type 2 diabetes, while biomarkers of plant-derived ALA were not significantly linked with diabetes risk.
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathy Trieu, Saiuj Bhat, Zhaoli Dai, Karin Leander, Bruna Gigante, Frank Qian, Andres Ardisson Korat, Qi Sun, Xiongfei Pan, Federica Laguzzi, Tommy Cederholm, Ulf De Faire, Mai-Lis Hellenius, Jason H. Wu, Ulf Riserus, Matti Marklund
Review
Infectious Diseases
Chih-Hung Wang, Chi-Chun Yang, Wan-Ting Hsu, Frank Qian, Julia Ding, Han-Ping Wu, Jih-Jin Tsai, Chia-Jui Yang, Ming Yang Su, Shyr-Chyr Chen, Chien-Chang Lee
Summary: This study compared antibiotic therapy with surgery for the initial treatment of acute appendicitis and found that carbapenems might be recommended as the first-line antibiotic regimen for non-operative management in adult patients. However, more randomized controlled trials are needed to confirm these findings, especially for pediatric patients.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Chen Wei, Frank Qian, Ye Liu, Luigi Maione, Huei-Ching Hsu, Wan-Ting Hsu, Chien-Chang Lee
Summary: This study found that obesity was associated with higher in-hospital 30-day mortality risk in influenza patients, but with reduced mortality risk in pneumonia patients. This divergent effect of obesity in different infections was not adequately explained by lower admission threshold.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
William S. Harris, Nathan L. Tintle, Fumiaki Imamura, Frank Qian, Andres V. Ardisson Korat, Matti Marklund, Luc Djousse, Julie K. Bassett, Pierre-Hugues Carmichael, Yun-Yu Chen, Yoichiro Hirakawa, Leanne K. Kupers, Federica Laguzzi, Maria Lankinen, Rachel A. Murphy, Cecilia Samieri, Mackenzie K. Senn, Peilin Shi, Jyrki K. Virtanen, Ingeborg A. Brouwer, Kuo-Liong Chien, Gudny Eiriksdottir, Nita G. Forouhi, Johanna M. Geleijnse, Graham G. Giles, Vilmundur Gudnason, Catherine Helmer, Allison Hodge, Rebecca Jackson, Kay-Tee Khaw, Markku Laakso, Heidi Lai, Danielle Laurin, Karin Leander, Joan Lindsay, Renata Micha, Jaako Mursu, Toshiharu Ninomiya, Wendy Post, Bruce M. Psaty, Ulf Riserus, Jennifer G. Robinson, Aladdin H. Shadyab, Linda Snetselaar, Aleix Sala-Vila, Yangbo Sun, Lyn M. Steffen, Michael Y. Tsai, Nicholas J. Wareham, Alexis C. Wood, Jason H. Y. Wu, Frank Hu, Qi Sun, David S. Siscovick, Rozenn N. Lemaitre, Dariush Mozaffarian
Summary: The study found that higher levels of omega-3 fatty acids in the blood are associated with a lower risk of all-cause mortality, particularly with long chain omega-3 fatty acids. This association may help reduce the risk of death from cardiovascular disease, cancer, and other causes.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Zhipeng Kan, Yijun Wang, Qian Chen, Xiaoyu Tang, Henry J. Thompson, Jinbao Huang, Jinsong Zhang, Feng Gao, Yong Shen, Xiaochun Wan
Summary: In this study, it was found that green tea extract treatment significantly improved spatial learning and memory ability in 5XFAD mice, reduced the formation of A beta, and decreased the levels of related proteins. GTE also suppressed glial cell activation and inflammatory responses, while increasing synaptic protein levels.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Wenjing Liao, Suyu Liu, Yunxi Chen, Yashuai Kong, Dongxu Wang, Yijun Wang, Tiejun Ling, Zhongwen Xie, Irada Khalilova, Jinbao Huang
Summary: This study analyzed the chemical compositions of Keemun black tea and Dianhong black tea and investigated their lipid-lowering effects in a high-fat diet mouse model. The results showed that Dianhong black tea was more effective in preventing hepatic fat accumulation and stimulating fecal fat excretion compared to Keemun black tea.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Guangshan Zhao, Lian Yang, Wenshen Zhong, Yuze Hu, Yu Tan, Zhe Ren, Qiuyan Ban, Chung S. Yang, Yifei Wang, Zhiping Wang
Summary: The study compared the effects of POD and RES in ameliorating energy homeostasis imbalance and found that POD increased the levels of valeric acid and caproic acid in feces by modifying gut microbiota, and was more effective in improving lipid metabolism than RES.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Wenjing Liao, Wenjiao Li, Suyu Liu, Dong Tang, Yunxi Chen, Yijun Wang, Zhongwen Xie, Jinbao Huang
Summary: The nonabsorptive components of Keemun black tea and Dianhong black tea can modulate the intestinal microbiota and increase the production of short-chain fatty acids. These components also have different effects on the abundance of beneficial bacteria compared to fructooligosaccharide, indicating their potential as novel prebiotics.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Chemistry, Applied
Zeyu Wang, Jinbao Huang, Dawei Yun, Huimin Yong, Jun Liu
Summary: Four catechins were conjugated onto chitosan to develop antioxidant food packaging films. The catechins improved the antioxidant activity of chitosan, with EGCG-g-CS being the most effective. The developed films showed enhanced thickness, strength, thermal stability, and antioxidant activity compared to chitosan films.
FOOD HYDROCOLLOIDS
(2022)
Article
Food Science & Technology
Dongxu Wang, Taotao Wang, Zhihong Zhang, Zhanming Li, Yuanxin Guo, Guangshan Zhao, Liang Wu
Summary: A high dietary intake of polyphenols is associated with a reduced risk of chronic diseases, particularly those related to inflammation. However, the exact mechanisms responsible for their anti-inflammatory effects in the body are not yet fully understood. While animal studies have shown positive effects of polyphenols on inflammation, clinical trials have produced variable results, with some even showing negative outcomes. This review summarizes recent research on the effects of dietary polyphenols on inflammation and metabolic disorders in vivo, including their biological activities, general anti-inflammatory mechanisms, receptor targets, clinical evidence, safety concerns, potential use of nanodelivery systems and polyphenol polymers, and directions for future research.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Food Science & Technology
Qiuyan Ban, Wenjing Chi, Yu Tan, Shiqiong Wang, Ning Li, Lianjun Song, Xianqing Huang, Dongxu Wang, Wanxi Peng, Daniel Granato, Guangshan Zhao
Summary: The research indicates that melatonin can improve lipid metabolism by modifying gut microbiota and glucose metabolism through the melatonin receptor signaling pathway. However, the effect of melatonin consumption on glucose homeostasis by affecting gut microbiota in diabetes has not been studied. In this experiment, melatonin administration through drinking water for 12 weeks in db/db mice, a type 2 diabetes model, showed reduced diabetic symptoms, increased insulin sensitivity, and improved glycemia. Melatonin reprogrammed the gut microbiota and reduced the levels of short-chain fatty acids, leading to enhanced insulin sensitivity and lower fasting blood glucose levels.
FOOD SCIENCE & NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Jieyao Yu, Chi-Tang Ho, Zhi Lin, Yin Zhu, Zhihui Feng, Dejiang Ni, Shengchun Zeng, Xuehong Zeng, Yijun Wang, Jingming Ning, Liang Zhang, Xiaoting Zhai, Xiaochun Wan
Summary: The volatile fraction of Lu'an Guapian green tea infusion was isolated and analyzed, revealing 52 aroma-active compounds. The aroma profiles and quantitative data of premium and common grade showed significant differences, with the flowery attribute being higher in premium grade and cooked vegetable-like notes being more prominent in common grade. Key odorants contributing to the aroma of premium grade were identified, and their concentration differences may be a main factor affecting the aroma quality between the two grades.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Xiaoyu Tang, Zhipeng Kan, Na Li, Jinbao Huang, Jinsong Zhang, Henry J. Thompson, Feng Gao, Yong Shen, Liang Zhang, Zhongwen Xie, Xiaochun Wan, Yijun Wang
Summary: Large-leaf yellow tea (LYT) improves cognitive ability and reduces β-amyloid (Aβ) production by inhibiting BACE1 activity. The therapeutic effects of LYT may be associated with the regulation of insulin signaling pathways.
Article
Food Science & Technology
Guangshan Zhao, Jianyuan Teng, Ruixia Dong, Qiuyan Ban, Lian Yang, Kang Du, Yifei Wang, Hanlin Pu, Chung S. Yang, Zhe Ren
Summary: Our previous study found that large-leaf yellow tea had hypoglycemic activity in obese mice and was safe in healthy mice. In this study, we investigated the effects of the tea on diabetes and diabetic nephropathy. The results showed that the tea reduced diabetic symptoms, improved glucose and lipid metabolism, and prevented diabetic nephropathy in diabetic mice.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)