Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis

Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation

(2021) Federica Ciregia et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Insulin Exacerbates Inflammation in Fibroblast-Like Synoviocytes

(2020) Li Qiao et al.   INFLAMMATION

Contracture and transient receptor potential channel upregulation in the anterior glenohumeral joint capsule of patients with end-stage osteoarthritis

(2020) Abby Chainani et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

Synovial fibroblasts and articular tissue remodelling: Role and mechanisms

(2020) Thomas Pap et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury

(2020) Tomohiro Yokota et al.   CELL

TAT-Beclin-1 induces severe synovial hyperplasia and does not protect from injury-induced osteoarthritis in mice

(2020) J.S. Rockel et al.   OSTEOARTHRITIS AND CARTILAGE

Single cell sequencing revealed the underlying pathogenesis of the development of osteoarthritis

(2020) Chenlu Li et al.   GENE

Enhanced asthma-related fibroblast to myofibroblast transition is the result of profibrotic TGF-β/Smad2/3 pathway intensification and antifibrotic TGF-β/Smad1/5/(8)9 pathway impairment

(2020) Dawid Wnuk et al.   Scientific Reports

Regulation of MMP and TIMP expression in synovial fibroblasts from knee osteoarthritis with flexion contracture using adenovirus-mediated relaxin gene therapy

(2019) Jae Han Ko et al.   KNEE

15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts

(2019) Carlos Vaamonde-Garcia et al.   BIOCHEMICAL PHARMACOLOGY

Cartilage Wear Particles Induce an Inflammatory Response Similar to Cytokines in Human Fibroblast‐Like Synoviocytes

(2019) Eben G. Estell et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Computational Deconvolution of Synovial Tissue Cellular Composition: Presence of adipocytes in synovial tissues decreased during arthritis pathogenesis and progression

(2019) Wenhui Wang et al.   PHYSIOLOGICAL GENOMICS

TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways

(2019) Shu-Jui Kuo et al.   Aging-US

Site-specific absence of microfibrillar-associated protein 4 (MFAP4) from the internal elastic membrane of arterioles in the rheumatoid arthritis synovial membrane: an immunohistochemical study in patients with advanced rheumatoid arthritis versus osteoar

(2019) Anne Friesgaard Christensen et al.   APMIS

cAMP Attenuates TGF-β's Profibrotic Responses in Osteoarthritic Synoviocytes: Involvement of Hyaluronan and PRG4

(2018) Marwa M. Qadri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Morphological evidence of telocytes in human synovium

(2018) Irene Rosa et al.   Scientific Reports

Study of the mechanism underlying hsa-miR338-3p downregulation to promote fibrosis of the synovial tissue in osteoarthritis patients

(2018) Changzhi Song et al.   MOLECULAR BIOLOGY REPORTS

Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results of three prospective cohort studies

(2018) M.J.M. Minten et al.   OSTEOARTHRITIS AND CARTILAGE

The changing role of TGFβ in healthy, ageing and osteoarthritic joints

(2017) Peter M. van der Kraan   Nature Reviews Rheumatology

Toward understanding the role of cartilage particulates in synovial inflammation

(2017) A.M. Silverstein et al.   OSTEOARTHRITIS AND CARTILAGE

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

MicroRNA-29a Counteracts Synovitis in Knee Osteoarthritis Pathogenesis by Targeting VEGF

(2017) Jih-Yang Ko et al.   Scientific Reports

Screening of gene signatures for rheumatoid arthritis and osteoarthritis based on bioinformatics analysis

(2016) Peiheng He et al.   Molecular Medicine Reports

Autophagy: controlling cell fate in rheumatic diseases

(2016) Jason S. Rockel et al.   Nature Reviews Rheumatology

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses

(2016) Wiparat Manuyakorn et al.   PLoS One

Synovitis biomarkers:ex vivocharacterization of three biomarkers for identification of inflammatory osteoarthritis

(2015) Cecilie Kjelgaard-Petersen et al.   BIOMARKERS

Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

(2015) Dennis F. G. Remst et al.   RHEUMATOLOGY

Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

(2014) Yue Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

(2013) Charles Godbout et al.   PLoS One

Gene Expression Analysis of Murine and Human Osteoarthritis Synovium Reveals Elevation of Transforming Growth Factor β-Responsive Genes in Osteoarthritis-Related Fibrosis

(2013) D. F. G. Remst et al.   Arthritis & Rheumatology

Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo

(2011) Tobias B. Kurth et al.   ARTHRITIS AND RHEUMATISM

Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection

(2011) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture

(2010) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo

(2010) Rachael S Watson et al.   LABORATORY INVESTIGATION

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL