Sex hormone–binding globulin: biomarker and hepatokine?

Using human genetics to understand the disease impacts of testosterone in men and women

(2020) Katherine S Ruth et al.   NATURE MEDICINE

Sex hormone-binding globulin overexpression protects against high fat diet induced obesity in transgenic male mice

(2020) Cristina Saez-Lopez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Contribution of liver fat to weight loss-induced changes in serum hepatokines: a randomized-controlled trial

(2019) Ine Telgenkamp et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Stephen A Harrison et al.   LANCET

The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials

(2019) Xiaoshuai Zhang et al.   International Journal of Endocrinology

Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars

(2018) Panu K. Luukkonen et al.   DIABETES CARE

Evaluating the potential role of pleiotropy in Mendelian randomization studies

(2018) Gibran Hemani et al.   HUMAN MOLECULAR GENETICS

Sex Hormone-Binding Globulin Expression Correlates with Acetyl-CoA Carboxylase and Triglyceride Content in Human Liver

(2018) Cristina Sáez-López et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Reappraisal of Testosterone’s Binding in Circulation: Physiological and Clinical Implications

(2017) Anna L Goldman et al.   ENDOCRINE REVIEWS

Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications

(2017) Franck Mauvais-Jarvis et al.   ENDOCRINE REVIEWS

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox

(2017) Cristina Saez-Lopez et al.   Scientific Reports

Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis

(2016) Chenxiao Liu et al.   CYTOKINE

Proinflammatory environment and role of TNF-α in endometrial function of obese women having polycystic ovarian syndrome

(2016) L Oróstica et al.   INTERNATIONAL JOURNAL OF OBESITY

Genome-wide association study with 1000 genomes imputation identifies signals for nine sex hormone-related phenotypes

(2015) Katherine S Ruth et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in theGCKRGene

(2015) Nicola Santoro et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due toPNPLA3Sequence Variant

(2015) Rosellina M. Mancina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Novel insights in SHBG regulation and clinical implications

(2015) Rafael Simó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Modulation of Glucokinase Regulatory Protein: A Double-Edged Sword?

(2015) Martijn C.G.J. Brouwers et al.   TRENDS IN MOLECULAR MEDICINE

Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome

(2015) Felix R. Day et al.   Nature Communications

Adiponectin Upregulates SHBG Production: Molecular Mechanisms and Potential Implications

(2014) Rafael Simó et al.   ENDOCRINOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

(2014) Julia Kozlitina et al.   NATURE GENETICS

Intensive insulin therapy increases sex hormone-binding globulin in newly diagnosed type 2 diabetic patients

(2013) Guoyu Tong et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Oleic acid increases hepatic sex hormone binding globulin production in men

(2013) Cristina Sáez-López et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Polycystic Ovary Syndrome with Hyperandrogenism Is Characterized by an Increased Risk of Hepatic Steatosis Compared to Nonhyperandrogenic PCOS Phenotypes and Healthy Controls, Independent of Obesity and Insulin Resistance

(2012) Helen Jones et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Body mass index is the most useful predictive factor for the onset of nonalcoholic fatty liver disease: a community-based retrospective longitudinal cohort study

(2012) Teruki Miyake et al.   JOURNAL OF GASTROENTEROLOGY

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro

(2012) Carlo Pirazzi et al.   JOURNAL OF HEPATOLOGY

Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study

(2012) S. SWEETLAND et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways

(2012) Rafael Simó et al.   MOLECULAR ENDOCRINOLOGY

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

(2012) Andrea D. Coviello et al.   PLoS Genetics

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction

(2011) G. L. Hammond   BIOLOGY OF REPRODUCTION

Potential Role of Tumor Necrosis Factor-  in Downregulating Sex Hormone-Binding Globulin

(2011) R. Simo et al.   DIABETES

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

(2011) M. G. Rees et al.   DIABETOLOGIA

Sex hormone-binding globulin and type 2 diabetes mellitus

(2011) Trang N. Le et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Relationships of Circulating Sex Hormone-Binding Globulin With Metabolic Traits in Humans

(2010) A. Peter et al.   DIABETES

Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated Dyslipidemia

(2010) Paul W. Ladenson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peroxisome-Proliferator Receptor γ Represses Hepatic Sex Hormone-Binding Globulin Expression

(2009) David M. Selva et al.   ENDOCRINOLOGY

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

(2009) John R.B. Perry et al.   HUMAN MOLECULAR GENETICS

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4α

(2009) David M Selva et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome

(2009) Michel Pugeat et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides

(2008) Jaspal S Kooner et al.   NATURE GENETICS