Aconitine induces mitochondrial energy metabolism dysfunction through inhibition of AMPK signaling and interference with mitochondrial dynamics in SH-SY5Y cells

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

Classification, hepatotoxic mechanisms, and targets of the risk ingredients in traditional Chinese medicine-induced liver injury

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Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression

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Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer

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Aconitine induces cardiomyocyte damage by mitigating BNIP3‐dependent mitophagy and the TNFα‐NLRP3 signalling axis

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Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade

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Mitochondrial dynamics, a key executioner in neurodegenerative diseases

(2018) Komal Panchal et al.   MITOCHONDRION

Mitochondrial dynamics in neuronal injury, development and plasticity

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Aconitine: A potential novel treatment for systemic lupus erythematosus

(2017) Xiaodong Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin

(2017) Xiaofang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1

(2017) Traci L. Marin et al.   Science Signaling

Doxycycline protects against ROS-induced mitochondrial fragmentation and ISO-induced heart failure

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Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

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Metabolic regulation of mitochondrial dynamics

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AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

(2016) E. Q. Toyama et al.   SCIENCE

Mitochondrial Dynamics and Metabolic Regulation

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Case reports of aconite poisoning in mainland China from 2004 to 2015: A retrospective analysis

(2016) Haoran Li et al.   Journal of Forensic and Legal Medicine

Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines

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A review on phytochemistry, pharmacology and toxicology studies ofAconitum

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Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

The role of mitochondrial DNA mutations and free radicals in disease and ageing

(2013) M. Lagouge et al.   JOURNAL OF INTERNAL MEDICINE

Conserved regulatory elements in AMPK

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Warburg and Crabtree Effects in Premalignant Barrett's Esophagus Cell Lines with Active Mitochondria

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Aconitum alkaloid content and the high toxicity of aconite tincture

(2012) Thomas Y.K. Chan   FORENSIC SCIENCE INTERNATIONAL

Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins

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AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Causes and prevention of herb-induced aconite poisonings in Asia

(2011) Thomas YK Chan   HUMAN & EXPERIMENTAL TOXICOLOGY

Metabolomics Study on the Toxicity of Aconite Root and Its Processed Products Using Ultraperformance Liquid-Chromatography/Electrospray-Ionization Synapt High-Definition Mass Spectrometry Coupled with Pattern Recognition Approach and Ingenuity Pathways Analysis

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The toxicity of aconitine, emodin on ICC cell and the anagonist effect of the compatibility

(2010) Peng Cheng et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

(2010) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism study of Aconitum-induced neurotoxicity in PC12 cells: Involvement of dopamine release and oxidative damage

(2010) Yinglan Zhao et al.   NEUROTOXICOLOGY

Study of neurotoxic effects and underlying mechanisms of aconitine on cerebral cortex neuron cells

(2009) Cheng Peng et al.   ARCHIVES OF PHARMACAL RESEARCH

Aconitum in Traditional Chinese Medicine—A valuable drug or an unpredictable risk?

(2009) Judith Singhuber et al.   JOURNAL OF ETHNOPHARMACOLOGY

Toxicity Assessment of Nine Types of Decoction Pieces from the Daughter Root ofAconitum carmichaeli(Fuzi) Based on the Chemical Analysis of their Diester Diterpenoid Alkaloids

(2009) Guanghua Lu et al.   PLANTA MEDICA